New hope for dry AMD?

Evans, James B.; Syed, Basharut A.
July 2013
Nature Reviews Drug Discovery;Jul2013, Vol. 12 Issue 7, p501
Academic Journal
The article discusses dry age-related macular degeneration (AMD) and new therapeutic options. Information on the prevalence of dry AMD is provided, as well as its pathogenesis. In a Phase II trial, eculizumab failed to decrease the growth rate of geographic atrophy in dry AMD. It notes that the AREDS protocol is aimed at addressing oxidative stress, which is involved in the AMD pathogenesis. Other therapeutic options are cell and gene therapies, visual cycle modulators and vascular enhancers.


Related Articles

  • Stem Cell-Based Therapeutic Applications in Retinal Degenerative Diseases. Huang, Yiming; Enzmann, Volker; Ildstad, Suzanne // Stem Cell Reviews & Reports;Jun2011, Vol. 7 Issue 2, p434 

    Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration...

  • Kenalog: Does It Still Fit Into Clinical Practice? Stephenson, Michelle // Review of Ophthalmology;Aug2006, Vol. 13 Issue 8, p66 

    The article reports on the use of intravitreal kenalog for the treatment of intraocular neovascular and edematous conditions. It discusses the effects and side effects of the treatment to various vision disorders. Kenalog treatment has been found most effective for intraretinal edematous...

  • Macular degeneration is a family affair.  // Patient Care;11/15/1998, Vol. 32 Issue 18, p158 

    Reports on the study conducted by researchers at Oregon Health Sciences University School of Medicine, Portland identifying patients at risk for age-related macular degeneration (ARMD). Identification of a family with high prevalence of ARMD of the dry phenotype; Determination of chromosomal...

  • Gene therapy breakthrough seen in Leber's congenital amaurosis. Charters, Lynda // Ophthalmology Times;4/15/2002, Vol. 27 Issue 8, p1 

    Provides information on a study which examined the gene therapies for retinal dystrophies. Clinical relevance of gene therapies; Efficacy of gene therapies in treating retinal diseases; Information on Leber's congenital amaurosis.

  • Retinal Degenerations: From Cell Signaling to Cell Therapy; Pre-Clinical and Clinical Issues. Cronin, Thérèse; Léveillard, Thierry; Sahel, José-Alain // Current Gene Therapy;Apr2007, Vol. 7 Issue 2, p121 

    Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review...

  • Clinical Trials in Retinal Dystrophies. Grob, Seanna R.; Finn, Avni; Papakostas, Thanos D.; Eliott, Dean // Middle East African Journal of Ophthalmology;Jan-Mar2016, Vol. 23 Issue 1, p49 

    Research development is burgeoning for genetic and cellular therapy for retinal dystrophies. These dystrophies are the focus of many research efforts due to the unique biology and accessibility of the eye, the transformative advances in ocular imaging technology that allows for in vivo...

  • Routine retinal examination in patients with acute stroke in Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria. Abah, Emmanuel R.; Obiako, O. R.; Mahmoud-Ajeigbe, A. F.; Audu, O. // International Journal of Nutrition, Pharmacology, Neurological D;Sep-Dec2012, Vol. 2 Issue 3, p229 

    Background: There is high prevalence of hypertension and diabetes in patients with stroke, and these are also major risk factors for potentially blinding retinal diseases. This study was conducted to determine the prevalence and types of retinal abnormalities in patients with acute stroke in...

  • MACULAR HOLE.  // Review of Optometry;4/15/2010 Supplement, p35A 

    The article focuses on macular holes, the small lamellar defects in the outer retina or retinal epithelium. It discusses the signs, symptoms and prevalence of macular holes which occur in patients of all ages. The associated causes of the defects are cited including solar retinopathy,...

  • Gene discovery a focal point for macular degeneration. Charters, Lynda; Zhang, Kang // Ophthalmology Times;04/01/2001, Vol. 26 Issue 7, p1 

    Focuses on the discovery of a gene called ELOVL4, which is responsible for dominant Stargardt's macular dystrophy and other forms of macular degeneration. Results of the analysis of ELOVL4; Therapeutic interventions; Background information on the screening for patients with age-related macular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics