TITLE

Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett’s oesophagus-associated adenocarcinoma

AUTHOR(S)
Kulke, M H; Odze, R D; Thakore, K S; Thomas, G; Wang, H; Loda, M; Eng, C
PUB. DATE
March 2001
SOURCE
British Journal of Cancer;3/15/2001, Vol. 84 Issue 6, p748
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
PTEN is a putative tumour suppressor gene located on chromosome band 10q23. Mutations in PTEN have been identified in numerous human malignancies, including cancers of the brain, endometrium, ovary, and prostate. In this study, we screened 80 Barrett's oesophagus-associated adenocarcinomas (BOAd) for loss of heterozygosity (LOH) at 10q23, using the microsatellite markers D10S541, D10S219, and D10S551. Tumours demonstrating LOH were then screened for the presence or absence of PTEN mutations. LOH at one or more loci was identified in 17/80 (21%) cases. In none of these cases did we detect mutations in PTEN. The presence of LOH did not correlate with patient age, tumour stage, degree of differentiation, presence of perineural or vascular invasion, or overall survival. We conclude that LOH at chromosome 10q23 is uncommon in BOAd, is not associated with mutations in the PTEN tumour suppressor gene, and does not correlate with the clinical or pathologic features of these tumours. It is possible that PTEN is inactivated through other mechanisms in BOAd.
ACCESSION #
8877371

 

Related Articles

  • E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus. Evangelou, K.; Kotsinas, A.; Mariolis-Sapsakos, T.; Giannopoulos, A.; Tsantoulis, P. K.; Constantinides, C.; Troupis, T. G.; Salmas, M.; Kyroudis, A.; Kittas, C.; Gorgoulis, V. G. // Journal of Clinical Pathology;May2008, Vol. 61 Issue 5, p601 

    Background: E2F-1 expression is positively associated with tumour growth in oesophageal squamous-cell carcinomas (OSCC), while it exhibits oncosuppressive features in colonic adenocarcinomas (AC). To date there are no data regarding E2F-1 expression and its relationship with tumour kinetics...

  • Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis. Wang, S.; Zhan, M.; Yin, J.; Abraham, J. M.; Mori, Y.; Sato, F.; Xu, Y.; Olaru, A.; Berki, A. T.; Li, H.; Schulmann, K.; Kan, T.; Hamilton, J. P.; Paun, B; Yu, M. M.; Jin, Z; Cheng, Y.; Ito, T.; Mantzur, C.; Greenwald, B. D. // Oncogene;6/1/2006, Vol. 25 Issue 23, p3346 

    To investigate the relationship between Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), we determined gene expression profiles of discrete pathological stages of esophageal neoplasia using a sequence-verified human cDNA microarray. Fifty one RNAs, comprising 24 normal esophagi...

  • Transcriptionally Active Human Papillomavirus Is Strongly Associated With Barrett's Dysplasia and Esophageal Adenocarcinoma. Rajendra, Shanmugarajah; Wang, Bin; Snow, Elizabeth T; Sharma, Prateek; Pavey, Darren; Merrett, Neil; Ball, Madeleine J; Brain, Terry; Fernando, Ruchira; Robertson, Iain K // American Journal of Gastroenterology;Jul2013, Vol. 108 Issue 7, p1082 

    OBJECTIVES:The role of human papillomavirus (HPV) in Barrett's esophagus (BE) remains unclear. The few studies that have previously investigated HPV and esophageal adenocarcinoma (EAC) or BE have produced either negative data or positive results of doubtful clinical/etiological significance or...

  • Differential gene expression in normal esophagus and Barrett’s esophagus. Jacob Wang; Rong Qin; Yan Ma; Huiyun Wu; Peters, Heiko; Tyska, Matthew; Shaheen, Nicholas J.; Chen, Xiaoxin // Journal of Gastroenterology;2009, Vol. 44 Issue 9, p897 

    As the premalignant lesion of human esophageal adenocarcinoma (EAC), Barrett’s esophagus (BE) is characterized by intestinal metaplasia in the normal esophagus (NE). Gene expression profiling with microarray and serial analysis of gene expression (SAGE) may help us understand the...

  • Large intra- and inter-individual variability of genes expression levels limits potential predictive value of molecular diagnosis of dysplasia in Barrett’s esophagus. Hennig, Ewa E.; Mikula, Michal; Orlowska, Janina; Jarosz, Dorota; Bielasik, Andrzej; Regula, Jaroslaw; Ostrowski, Jerzy // Journal of Molecular Medicine;Feb2008, Vol. 86 Issue 2, p233 

    Barrett’s esophagus represents a well-defined precursor lesion of esophageal adenocarcinoma, although only a subset of patients with these lesions advances to invasive cancer. Currently, reliable markers predicting neoplastic progression in Barrett’s esophagus are lacking. The only...

  • Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus. Volkweis, Bernardo Silveira; Gurski, Richard Ricachenevsky; Meurer, Luise; Pretto, Guilherme Gonçalves; Mazzini, Guilherme da Silva; Edelweiss, Maria Isabel // Gastroenterology Research & Practice;2012, p1 

    Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett's esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the...

  • Sulindac Prevents Esophageal Adenocarcinomas Induced by Gastroduodenal Reflux in Rats. Sung Wook Kim; Tae Jung Jang; Ki Hoon Jung; Jung Il Suh // Yonsei Medical Journal;12/31/2008, Vol. 48 Issue 6, p1020 

    Purpose: It is known that cyclooxygenase (COX)-2 expression is increased in Barrett's esophagus and esophageal adenocarcinomas. We studied COX-2 expression and the effect sulindac has on the genesis of Barrett's esophagus and adenocarcinoma in rats undergoing esophagogastroduodenal anastomosis...

  • P53 and Ki-67 overexpression in gastroesophageal reflux disease – Barrett's esophagus and adenocarcinoma sequence. Binato, M.; Gurski, R. R.; Fagundes, R. B.; Meurer, L.; Edelweiss, M. I. // Diseases of the Esophagus;Oct2009, Vol. 22 Issue 7, p588 

    Gastroesophageal reflux disease (GERD) is a major risk factor for the development of esophageal adenocarcinoma (ACE). Many molecular alterations occur in esophageal carcinogenesis, yet the exact mechanism of ACE development remains unknown. This study aims to determine p53 protein and Ki-67...

  • Global Changes in Gene Expression of Barrett's Esophagus Compared to Normal Squamous Esophagus and Gastric Cardia Tissues. Hyland, Paula L.; Hu, Nan; Rotunno, Melissa; Su, Hua; Wang, Chaoyu; Wang, Lemin; Pfeiffer, Ruth M.; Gherman, Barbara; Giffen, Carol; Dykes, Cathy; Dawsey, Sanford M.; Abnet, Christian C.; Johnson, Kathryn M.; Acosta, Ruben D.; Young, Patrick E.; Cash, Brooks D.; Taylor, Philip R. // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Background: Barrett's esophagus (BE) is a metaplastic precursor lesion of esophageal adenocarcinoma (EA), the most rapidly increasing cancer in western societies. While the prevalence of BE is increasing, the vast majority of EA occurs in patients with undiagnosed BE. Thus, we sought to identify...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics