TITLE

Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-mediated pathway

AUTHOR(S)
Ueoka, Y; Kato, K; Kuriaki, Y; Horiuchi, S; Terao, Y; Nishida, J; Ueno, H; Wake, N
PUB. DATE
February 2000
SOURCE
British Journal of Cancer;2/15/2000, Vol. 82 Issue 4, p891
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic biological effects on epithelial cells such as proliferation, motogenesis, invasiveness and morphogenesis. Peritoneal dissemination is critical for the progression of ovarian cancer, and our study revealed that HGF induces migration and invasion of ovarian cancer cells. We also demonstrated that HGF stimulates autophosphorylation of its receptor, followed by activation of the Ras-MAP (mitogen-activated peptide) kinase cascade. Moreover, infection of ovarian cancer cells with Ras dominant-negative adenovirus reduced the HGF-induced motogenic and invasive activities. Additionally, both MEK and PI3-kinase pathways downstream of Ras were involved in HGF-stimulated ovarian cancer cell invasiveness.
ACCESSION #
8877096

 

Related Articles

  • Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Ivan, Mircea; Bond, Jane A; Prat, Maria; Comoglio, Paolo Maria; Wynford-Thomas, David // Oncogene;5/22/97, Vol. 14 Issue 20, p2417 

    Hepatocyte Growth Factor (HGF) receptor, encoded by the protooncogene c-met, is overexpressed in many human tumours, including those of thyroid epithelium. The absence in most cases of any primary structural abnormality of the met gene suggests that overexpression is secondary to mutation of...

  • Hepatocyte growth factor accelerates restitution of intestinal epithelial cells. Nishimura, Shuji; Takahashi, Morio; Ota, Shinichi; Hirano, Masanori; Hiraishi, Hideyuki; Nishimura, S; Takahashi, M; Ota, S; Hirano, M; Hiraishi, H // Journal of Gastroenterology;1998, Vol. 33 Issue 2, p172 

    Many cytokines are involved in the repair of damaged tissue, and one of these, hepatocyte growth factor (HGF), is involved not only with liver regeneration but also in the repair of other tissues. To investigate the importance of HGF in the repair of the small intestine, we evaluated its effect...

  • Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis. Gual, Philippe; Giordano, Silvia; Williams, Tracy A; Rocchi, Stephane; Van Obberghen, Emmanuel; Comoglio, Paolo M // Oncogene;3/16/2000, Vol. 19 Issue 12, p1509 

    A distinctive property of Hepatocyte Growth Factor (HGF) is its ability to induce differentiation of tubular structures from epithelial and endothelial cells (branching tubulogenesis). The HGF receptor directly activates PI3 kinase, Ras and STAT signalling pathways and phosphorylates the...

  • Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways. Youchua Liu; Rajur, Krupa; Tolbert, Evelyn; Dworkin, Lance D. // Kidney International;Nov2000, Vol. 58 Issue 5, p2028 

    Examines the biological actions of endogenous hepatocyte growth factor (HGF) in chronic renal injury. Reasons for the progression of chronic kidney diseases into end-stage renal failure; Establishment of an HGF-producing renal epithelial cell line; Reduction of extracellular matrix accumulation...

  • Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis? Wong, A S T; Pelech, S L; Woo, M M M; Yim, G; Rosen, B; Ehlen, T; Leung, P C K; Auersperg, N // Oncogene;3/15/2001, Vol. 20 Issue 11, p1318 

    Since autocrine regulation of HGF-Met is implicated in many forms of human cancer, we investigated whether the predisposition to develop ovarian cancer in women with hereditary ovarian cancer syndromes involves changes in the expression of HGF-Met by the tissue of origin of epithelial ovarian...

  • Expression of HGF/NK4 in ovarian cancer cells suppresses intraperitoneal dissemination and extends host survival. Saga, Y; Mizukami, H; Suzuki, M; Urabe, M; Kume, A; Nakamura, T; Sato, I; Ozawa, K // Gene Therapy;Oct2001, Vol. 8 Issue 19, p1450 

    Peritoneal dissemination is the most frequent progression pathway of ovarian cancer and is therefore a key step to improve the prognosis. NK4, a large part of the α-chain of hepatocyte growth factor, is known to inhibit cancer cell migration. To characterize the function of NK4 and...

  • Effective inhibition of c-MET-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment. Kwon, Y; Smith, B D; Zhou, Y; Kaufman, M D; Godwin, A K // Oncogene;1/8/2015, Vol. 34 Issue 2, p144 

    The signaling mediated by c-MET and its ligand, hepatocyte growth factor (HGF), has been implicated in malignant progression of cancer involving stimulation of proliferation, invasion and metastasis. We studied the c-MET/HGF axis as a mediator of tumor-stromal interaction in ovarian cancer and...

  • A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells. Wojcik, E. J.; Sharifpoor, S.; Miller, N. A.; Wright, T. G.; Watering, R.; Tremblay, E. A.; Swan, K.; Mueller, C. R.; Elliott, B. E. // Oncogene;5/4/2006, Vol. 25 Issue 19, p2773 

    In the normal breast, hepatocyte growth factor (HGF) is primarily expressed by stromal cells, and stimulates in a paracrine manner epithelial cells expressing the HGF receptor (Met). In invasive human breast carcinomas, HGF and Met are frequently overexpressed, possibly establishing an autocrine...

  • Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Boccaccio, Carla; Ando, Margherita; Tamagnone, Luca; Bardelli, Alberto; Michieli, Paolo; Battistini, Carlo; Comoglio, Paolo M. // Nature;1/15/1998, Vol. 391 Issue 6664, p285 

    Presents research which showed that the third phase of the response of epithelial cells to hepatocyte growth factor (HGF) is dependent on the STAT pathway. Role of HGF; HGF receptor tyrosine kinase; First two phases; Electroporation of a tyrosine-phosphorylated peptide; Activation of signal...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics