TITLE

Maximal secretory capacity of somatotrope cells in obesity: comparison with GH deficiency

AUTHOR(S)
Maccario, M; Valetto, M R; Savio, P; Aimaretti, G; Baffoni, C; Procopio, M; Grottoli, S; Oleandri, S E; Arvat, E; Ghigo, E
PUB. DATE
January 1997
SOURCE
International Journal of Obesity & Related Metabolic Disorders;Jan1997, Vol. 21 Issue 1, p27
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To evaluate the maximal secretory capacity of somatotrope cells in obesity and to compare it with that in hypopituitaric patients with GH deficiency. DESIGN: Stimulation with GHRH. (1 μg/kg iv) combined with arginine (ARG, 0.5 g/kg iv), which strongly potentiates the GH response to the neurohormone, likely inhibiting hypothalamic somatostatin. The reproducibility of the GH response to GHRH + ARG was evaluated in a second session. SUBJECTS: Forty-five patients with simple obesity (OB 11 male and 34 female, age 40.5 ± 1.8 y, BMI 38.8 ± 1.1 kg/m²), 49 patients with hypopituitarism (GHD, 23 male and 26 female, 43.6± 2.4y, 24.7 ± 0.7 kg/m²) and 44 normal young volunteers (NS, 25 male and 19 female, 33.8 ± 1.0 y, 21.6 ± 0.3 kg/m²) were studied. MEASUREMENTS: GH levels were assayed by IRMA method, basally at - 60 and 0 min, and than every 15 min up to + 120 min. Basal IGF-I levels were assayed by RIA method, after acid-ethanol extraction. RESULTS: IGF-I levels in OB were lower (P < 0.005) than those in NS but higher (P < 0.005) than those in GHD. Mean peak GH response to GHRH + ARG in OB was clearly lower than that in NS (P < 0.005) and higher (P < 0.005) than that in GHD. Sixty-percent OB and 100% GHD showed peak GH responses lower than the minimum normal limit in NS (16.5 μg/I) while 4% OB and only 53% GHD with GH responses lower than 3 μg/I, the limit under which GH replacement therapy of severe deficiency is allowed. Good intraindividual reproducibility of the GH response to GHRH + arginine test was present in all groups (OB: r=0.78, P < 0.0001; GHD: r= 0.57, P< 0.003; NS: r=0.74, P< 0.0001;. CONCLUSIONS: The maximal secretory capacity of somatotrope cells is clearly less than normal in the obese but still more than is seen in GHD subjects. However, in about 50% of obese patients, the pituitary GH releasable pool overlaps with that of hypopituitaric patients with GH deficiency. Thus, even...
ACCESSION #
8853383

 

Related Articles

  • Comparative validation of the growth hormone releasing hormone and arginine test for the diagnosis of adult growth hormone deficiency using a growth hormone assay conforming to recent international recommendations. Gordon, Kirsty // Annals of Clinical Biochemistry;Sep2010, Vol. 47 Issue 5, p498 

    The article discusses the diagnosis of growth hormone deficiency (GHD) through comparative validation of growth hormone releasing hormone and arginine test. It states that the current international standard in diagnosing GHD is the insulin tolerance test (ITT). However, the authors claim that...

  • Citations and Clinicians' Notes: Growth Hormone: Receptors and Binding Proteins.  // Current Medical Literature: GH & Growth Factors;2003, Vol. 18 Issue 2, p44 

    Presents clinicians' notes on growth hormone. Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization; Dual regulation of phosphorylation of C/EBPbeta; Identification of a JAK2-independent pathway regulating growth hormone.

  • Growth hormone | Clinical.  // Current Medical Literature: GH & Growth Factors;2004, Vol. 19 Issue 1, p9 

    Presents clinicians' notes about clinical growth hormone (GH). Ghrelin concentrations in health children and adolescents; Effect of acute reduction of free fatty acids by acipimox on GH-releasing hormone-induced GH secretion in type 1 diabetics; Reproducibility of GH response to sprint exercise.

  • Growth Hormone Secretagogues. Isidro, Maria Luisa; Cordido, Fernando // Combinatorial Chemistry & High Throughput Screening;Mar2006, Vol. 9 Issue 3, p175 

    Growth hormone secretagogues (GHSs) are synthetic molecules that stimulate and amplify pulsatile pituitary growth hormone release, via a separate pathway distinct from GH releasing hormone/somatostatin. The activity of GHSs is not fully specific for GH secretion; some GHSs also have slight...

  • Transjecting growth hormone: continuous nightmare or controlled nuisance? Evaluation of a new needle-free device. Kaptein, Ad A. // Patient Preference & Adherence;2013, Vol. 7, p703 

    Background: Administering growth-hormone therapy (GHT) is a long-term treatment, associated with avoidance and phobic behaviors in the children involved. The current study examined GHT users' perceptions of a new needle-free device (ZomaJet Vision X [10 mg/mL]) with a lower injection volume...

  • Growth Hormone -- Therapy.  // Current Medical Literature: Growth, Growth Hormone, & Metabolism;2006, Vol. 1 Issue 2, p52 

    The article presents abstracts of medical research on growth hormone therapy. They include "Effect of Growth Hormone (GH) Treatment on the Final Height of 1258 Patients With Idiopathic GH Deficiency: Analysis of a Large International Database," "Growth Hormone Releasing Hormone Improves the...

  • Relationship between Cognitive Function, Growth Hormone and Insulin-Like Growth Factor I Plasma Levels in Aged Subjects. Rollero, Alessandro; Murialdo, Giovanni; Fonzi, Stefano; Garrone, Simona; Gianelli, Maria V.; Gazzerro, Elisabetta; Barreca, Antonina; Polleri, Alessandro // Neuropsychobiology;1998, Vol. 38 Issue 2, p73 

    Basal growth hormone (GH) and insulin-like growth factor I (IGF-I) as well as GH responses to GH-releasing hormone (GHRH) were studied in 22 subjects (7 females, 15 males), aged between 65 and 86 years. The study was aimed at investigating the possible correlations between the age-dependent...

  • Abuse of Recombinant Human Growth Hormone: Studies in Two Different Dog Models. Rigamonti, A. E.; Scanniffio, D.; Bonomo, S. M.; Cella, S. G.; Sartorio, A.; Müller, Eugenio E. // Neuroendocrinology;2004, Vol. 79 Issue 5, p237 

    The search for inappropriately high growth hormone (GH) titers in plasma has been widely used to detect GH abuse, despite many shortcomings especially related to the pulsatile nature of GH secretion. Hence, the need for new anti-doping strategies. In the present study dogs were used to evaluate...

  • Growth Hormone Releasing Hormone Expression During Postnatal Development in Growth Hormone-Deficient Ames Dwarf Mice:mRNA in situ Hybridization. Hurley, David L.; Wee, Beth E. F.; Phelps, Carol J. // Neuroendocrinology;1998, Vol. 68 Issue 3, p201 

    Several genetic mutations in mice and rats that produce lifelong growth hormone (GH) deficiency result in overexpression of GH-releasing hormone (GHRH) mRNA in hypothalamic arcuate nucleus neurons. In order to examine the development of this condition, GHRH mRNA expression was quantified in Ames...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics