Cerebellar vermis volume in major depressive disorder

Yucel, Kaan; Nazarov, Anthony; Taylor, Valerie; Macdonald, Kathryn; Hall, Geoffrey; MacQueen, Glenda
July 2013
Brain Structure & Function;Jul2013, Vol. 218 Issue 4, p851
Academic Journal
The vermis is located in the midline of the cerebellum and is involved in the regulation of affect and cognitive processes. Although changes in vermis size have been reported in several psychiatric disorders such as schizophrenia and bipolar disorder, no volumetric studies have been conducted on samples of patients with major depressive disorder (MDD). One-hundred and five adult subjects were recruited: 35 patients who were presenting for first treatment (FT; 22 females), 35 patients with known previous treatment (PT; 22 females), and 35 healthy controls (NC; 22 females), matched for age and gender. We compared the volumes of the total vermis, the anterior lobe (V1), the superior-posterior lobe (V2), and the inferior-posterior lobe (V3), among these study groups. Anterior vermis (V1) was larger in patients with MDD with a long history of antidepressant treatment compared to healthy controls. This finding was evident only in men [ F(2, 36) = 9.23, p = .001]. Patients in the FT group did not differ from healthy controls in any vermian region. We found no correlations between vermian subregional volumes and clinical variables such as illness duration or age at onset of illness. We speculate that the larger anterior vermis volumes might arise from abnormalities in connectivity or as compensatory responses to the prefrontal dysfunction noted in patients with MDD but confirmation of this hypothesis awaits further studies.


Related Articles

  • Cerebellar Telomere Length and Psychiatric Disorders. Dandan Zhang; Cheng, Lijun; Craig, David W.; Redman, Margot; Chunyu Liu // Behavior Genetics;Mar2010, Vol. 40 Issue 2, p250 

    We tested whether telomere length is altered in the brains of patients diagnosed with major depression (MD), bipolar disorder (BD) and schizophrenia (SZ) by measuring mean telomere length (mTL) with real-time PCR. The samples are cerebellar gray matter from 46 SZ, 46 BP, and 15 MD patients, and...

  • Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Agid, O.; Shapira, B.; Zislin, J.; Ritsner, M.; Hanin, B.; Murad, H.; Troudart, T.; Bloch, M.; Heresco-Levy, U.; Lerer, B. // Molecular Psychiatry;1999, Vol. 4 Issue 2, p163 

    The current focus on identifying genes which predispose to psychiatric illness sharpens the need to identify environmental factors which interact with genetic predisposition and thus contribute to the multifactorial causation of these disorders. One such factor may be early parental loss (EPL)....

  • The DISC locus in psychiatric illness. Chubb, J E; Bradshaw, N J; Soares, D C; Porteous, D J; Millar, J K // Molecular Psychiatry;Jan2008, Vol. 13 Issue 1, p36 

    The DISC locus is located at the breakpoint of a balanced t(1;11) chromosomal translocation in a large and unique Scottish family. This translocation segregates in a highly statistically significant manner with a broad diagnosis of psychiatric illness, including schizophrenia, bipolar disorder...

  • Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Thomson, P. A.; Wray, N. R.; Millar, J. K.; Evans, K. L.; Le Hellard, S.; Condie, A.; Muir, W. J.; Blackwood, D. H. R.; Porteous, D. J. // Molecular Psychiatry;Jul2005, Vol. 10 Issue 7, p657 

    The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major...

  • A family study of bipolar II disorder. Coryell, W.; Endicott, J.; Reich, T.; Andreasen, N.; Keller, M. // British Journal of Psychiatry;Jul84, Vol. 145, p49 

    Professional raters who were blind to proband diagnosis used the schedule for affective disorders and schizophrenia (SADS-L) and the Research Diagnostic Criteria (RDC) to evaluate 1,210 first-degree relatives of 327 probands with primary major depression, participating in the family sub-study of...

  • Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression. Koethe, D.; Llenos, I. C.; Dulay, J. R.; Hoyer, C.; Torrey, E. F.; Leweke, F. M.; Weis, S. // Journal of Neural Transmission;Aug2007, Vol. 114 Issue 8, p1055 

    The human endogenous cannabinoid system is an appealing target in the investigation of psychiatric disorders. In schizophrenia, endocannabinoids and their receptors are involved in the pathology of the disease. Previous studies reported an increased radioligand binding to cannabinoid receptors 1...

  • Zur Differenzialdiagnostik der Depersonalisationserlebnisse. Bürgy, M. // Der Nervenarzt;Jan2012, Vol. 83 Issue 1, p40 

    Depersonalization represents an unspecific symptom which is to be found across the entire spectrum of psychiatric nosology. Delineating the historical lines of development of the depersonalization concept and reviewing existing psychopathological experiential knowledge reveals that...

  • Mental disorders and risk of accidental death. Crump, Casey; Sundquist, Kristina; Winkleby, Marilyn A.; Sundquist, Jan // British Journal of Psychiatry;Oct2013, Vol. 203 Issue 4, p297 

    Background: Little is known about accidental death risks among psychiatric patients.Aims: To examine this issue in the most comprehensive study to date.Method: National cohort study of all Swedish adults (n = 6 908 922) in 2001-2008.Results:...

  • "I live with a mental illness".  // Good Health (Australia Edition);Jun2014, p50 

    The article provides information the major challenges faced by people living with schizophrenia, depression and bipolar at work. It explores the need for the patients to handle with the lasting stigma around mental illness, while they might be as productive and have their symptoms under control....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics