Abciximab added to urokinase increased amputation-free survival in peripheral arterial occlusion of the legs

Hiatt, William R.
July 2002
ACP Journal Club;Jul/Aug2002, Vol. 137 Issue 1, p12
Academic Journal
Provides information on a study that investigated whether a combination of urokinase and abciximab reduce complications and prolong amputation-free survival better than urokinase alone in patients with peripheral arterial occlusion of the legs. Study design and setting; Main outcome measures; Main results; Conclusion.


Related Articles

  • Critical Limb Ischemia: Definition and Natural History. Novo, S.; Coppola, G.; Milio, G. // Current Drug Targets - Cardiovascular & Haematological Disorders;Sep2004, Vol. 4 Issue 3, p219 

    The term critical limb ischemia refers to a condition characterized by chronic ischemic at-rest pain, ulcers, or gangrene in one or both legs attributable to objectively proven arterial occlusive disease. Critical limb ischemia implies chronicity and is to be distinguished from acute limb...

  • Relation between rates of leg amputation and distal arterial reconstructive surgery. Michaels, J.A.; Rutter, P.; Legg, F.M.; Galland, R.B. // BMJ: British Medical Journal (International Edition);12/3/94, Vol. 309 Issue 6967, p1479 

    Examines the relationship between rates of leg amputation for occlusive arterial disease and distal arterial reconstructive surgery in Oxford, England. Differences between districts in the volume and nature of reconstructive arterial surgery; Methodology of the treatment; Role of district of...

  • Long-term Results of Through-knee Amputation with Dorsal Musculocutaneous Flap in Patients with End-stage Arterial Occlusive Disease. Kock, Hans-Juergen; Friederichs, Jan; Ouchmaev, Alexander; Hillmeier, Joachim; Gumppenberg, Stephan // World Journal of Surgery;Aug2004, Vol. 28 Issue 8, p801 

    A modified technique of knee joint disarticulation using a dorsal musculocutaneous flap of the gastrocnemius muscle was first described in 1985. The operative results in 66 patients (33 women, 33 men; mean age 66.7 ± 11.3 years, range 42-93 years) with gangrene due to peripheral vascular...

  • Unilateral Lower Limb Paralysis After Aortobifemoral Bypass Graft for Ruptured Abdominal Aortic Aneurysm: A Case Report. Deylgat, Bert; Wallaert, Paul; De Smul, Gunther; Van Lysebeth, Luc; Ceuppens, Herman // Vascular & Endovascular Surgery;Dec2009, Vol. 43 Issue 6, p606 

    An 81-year-old man underwent an aortobifemoral bypass graft because of a ruptured abdominal aortic aneurysm. His postoperative recovery was complicated by unilateral lower limb paralysis caused by perioperative ischemia of the lumbosacral plexus. Ischemic lumbosacral plexopathy is an uncommon...

  • Prevalence of Risk Factors Predisposing to Foot Problems in Patients on Hemodialysis. Locking-Cusolito, Heather; Harwood, Lori; Wilson, Barbara; Burgess, Kathy; Elliot, Marlene; Gallo, Kerri; Ische, Janice; Lawrence-Murphy, Julie Ann; Ridley, Jane; Robb, Margaret; Taylor, Cheryl; Tigert, Judy // Nephrology Nursing Journal;Jul/Aug2005, Vol. 32 Issue 4, p373 

    A disturbingly high prevalence of single or bilateral lower extremity amputations in our program prompted us to conduct a study to identify the prevalence of risk factors that predispose patients on hemodialysis (HD) to foot problems. The study consisted of a one-time assessment of subjects'...

  • Urokinase salvages limbs threatened by severe arterial occlusions.  // Geriatrics;Jan94, Vol. 49 Issue 1, p55 

    Presents information on a research from Miami which showed that infusion of the thrombolytic agent urokinase (Abbokinase) significantly decreases the need for limb amputation in patients with severe arteriial occlusions.

  • ARTERIAL GRAFTS IN ARTERIOSCLEROSIS OBLITERANS. Martorell, Fernando // Angiology;Aug1958, Vol. 9 Issue 4, p250 

    Comments on the introduction of vascular grafts in the operative treatment of chronic arterial occlusions. Skepticism over safety and efficacy of the treatment procedure; Identification of limitations regarding its applicability; Formulation of well conducted plan of medical treatment to prevent...

  • Comparison of MR Angiography Versus Digital Subtraction Angiography as a Basis for Planning Treatment of Lower Limb Occlusive Disease. Vavrik, Joachim; Rohrmoser, Georg Michael; Madani, Babak; Ersek, Murat; Tscholakoff, Dimiter; Bucek, Robert A. // Journal of Endovascular Therapy (Allen Press Publishing Services;Jun2004, Vol. 11 Issue 3, p294 

    Purpose: To compare contrast-enhanced moving-bed magnetic resonance angiography (MRA) with digital subtraction angiography (DSA) for the ability to provide adequate information on which to construct a therapeutic strategy in patients suffering from peripheral arterial occlusive disease (PAOD)....

  • Early Postoperative Detection of Tissue Necrosis in Amputation Stumps With Indocyanine Green Fluorescence Angiography. Zimmermann, Alexander; Roenneberg, Casper; Wendorff, Heiko; Holzbach, Thomas; Giunta, Riccardo E.; Eckstein, Hans-Henning // Vascular & Endovascular Surgery;May2010, Vol. 44 Issue 4, p269 

    Objective: Amputations of the lower extremity due to irreversible ischemic tissue loss are performed as distally as possible. Therefore, oftentimes wound-healing disorders develop, requiring additional surgical treatment. Methods: The amputations stumps of 10 patients with irreversible ischemic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics