TITLE

ASSOCIATION OF HEPATITIS C VIRUS INFECTION TO NON HODGKIN'S LYMPHOMA: IS THE VOLCANO NEAR TO BURST?: A CASE CONTROL STUDY

AUTHOR(S)
SHAIKH, BASHIR AHMED; MUHAMMAD, SHAIKH KHALID; GURBAKHSHANI, KOURO MAL
PUB. DATE
October 2011
SOURCE
Medical Channel;Oct2011, Vol. 17 Issue 4, p25
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction & Objectives: Limited data is available on association of HCV infection and NHL in Pakistan. This was a matter of particular interest. So, this study was conducted to determine the association between HCV infection and NHL. Duration & Design: This 2 year observational, case control study was started on 1st January 2009 at C.M.C Larkana, after approval of ethical review committee. Methods & Materials: After informed written consent, blood samples from 292 NHL cases and 1168 age and sex matched controls meeting our selection criteria, were sent for detection of Anti-HCV Ab on 3rd generation ELISA. Pearson's chi-square test was applied to compare Anti-HCV Ab seropositivity in cases and controls and odd ratios were computed using SPSS.10. P value of .05 was taken as statistically significant. Results: 52 (17.8%) of cases, 45 (7.7%) controls in group 1 and 50 (8.6%) in group 2 were Anti-HCV Ab positive, with odd ratio of 2.59 (95% CI; 1.69 - 3.97) for control group 1 and 2.31 (95% CI; 1.52 - 3.50) for control group 2. P value was .000 for both. Beside, Anti-HCV Ab positive NHL cases were more likely to be in middle age (40-60) years with odd ratio of 3.68 (95% CI; 2.07 - 6.50) and p value of .000. Conclusion: Anti-HCV Ab seropositivity is associated with 2.5 times the risk of development of NHL and seropositive cases tend to be in middle age category than seronegative.
ACCESSION #
88332575

 

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