TITLE

Simultaneous UV spectrphotometric estimation of enalapril maleate and hydrochlorothiazide in tablets

AUTHOR(S)
Sowjanya, G.; Gangadhar, P.; Rao, P. Ramalingeswara; Subrahmanyam, P.; Suresh, P.
PUB. DATE
July 2012
SOURCE
Journal of Chemical & Pharmaceutical Research;2012, Vol. 4 Issue 7, p3483
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A simple, rapid and sensitive UV spectrophotometric method was developed for the simultaneous estimation of Enalapril maleate (ENM) and Hydrochlorothiazide (HCTZ) in pharmaceutical dosage forms. This method employs solving of simultaneous equations based on the measurement of absorbance at the λmax values of ENM (207nm) and HCTZ (272nm). Calibration curves were linear in the range of 5-50µg/mL and 5-30µg/mL for ENM and HCTZ respectively. Recovery studies for ENM and HCTZ were performed and the percentage recovery for both the drugs was obtained in the range of 98.4-99.1 % and 98.8-99.1 % respectively. The method showed good reproducibility and recovery with % RSD less than 2. The proposed method can be successfully applied for the determination of ENM and HCTZ in pharmaceutical formulations and is validated according to ICH guidelines.
ACCESSION #
88303589

 

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