Untangling huntingtin's mysteries
- Predictive testing for Huntington's disease. Harper, Peter S.; Morris, Michael J. // BMJ: British Medical Journal (International Edition);2/18/89, Vol. 298 Issue 6671, p404
Examines the progress and problems of predictive testing for Huntington's disease in Great Britain. Discovery of the genetic marker for the disease; Use of markers in predicting a serious and untreatable neurological disease; Determination of the disease through single genetic locus.
- Ethics of predictive testing for Huntington's chorea: the need for more information. Graufurd, D.I.O.; Harris, R. // British Medical Journal (Clinical Research Edition);7/26/1986, Vol. 293 Issue 6541, p249
Examines the ethics of predictive testing for Huntington's chorea. Usability of the DNA probe for research; Technical limitations of the DNA probe; Need for controlled clinical trials on the DNA probe.
- Genetic prediction and family structure in Huntington's chorea. Harper, Peter S.; Sarfarazi, Mansoor // British Medical Journal (Clinical Research Edition);6/29/1985, Vol. 290 Issue 6486, p1929
Investigates the association between the genetic prediction and family structure of Huntington's chorea in South Wales. Use of a DNA sequence marker; Identification and evaluation of limitations of the disease; Evaluation of families for the genetic linkage of the disease.
- Preimplantation genetic diagnosis of P450 oxidoreductase deficiency and Huntington Disease using three different molecular approaches simultaneously. Alberola, Trinitat M.; Bautista-Ll�cer, Rosa; Fern�ndez, Esther; Vendrell, Xavier; P�rez-Alonso, Manuel // Journal of Assisted Reproduction & Genetics;May2009, Vol. 26 Issue 5, p263
Purpose Description of the confluence of different molecular techniques to detect three different mutations in one cell. The man carries a 20 base pair insertion in exon 12 of the POR gene (c.1551=1552ins20), and the woman carries a point mutation in exon 8 of the POR gene (c.859G>C) plus a...
- Something in the way they move clue to Huntington's . Moulton, Donalee // CMAJ: Canadian Medical Association Journal;4/18/2000, Vol. 162 Issue 8, p1196
Reports on the medical discovery of the mechanism and cause of motor coordination difficulties that stem from Huntington's Disease (HD). Comments from Christopher Ross that their identification of a genetic marker for HD may help them find drug treatment; Relevance of findings for other genetic...
- WCHD abstracts: platform presentations. // Journal of Neurology, Neurosurgery & Psychiatry;Oct2005 Supplement 4, Vol. 76, pA16
The article presents abstracts on medical topics which include "Pathogenic mechanisms in Huntington's disease: clues to possible therapeutic strategies," "Regional specificity of transcriptional changes in early grade Huntington's disease brain," and "Early clinical markers of Huntington's disease."
- Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease. Novak, Marianne J. U.; Warren, Jason D.; Henley, Susie M. D.; Draganski, Bogdan; Frackowiak, Richard S.; Tabrizi, Sarah J. // Brain: A Journal of Neurology;Apr2012, Vol. 135 Issue 4, p1165
Huntington's disease is an inherited neurodegenerative disease that causes motor, cognitive and psychiatric impairment, including an early decline in ability to recognize emotional states in others. The pathophysiology underlying the earliest manifestations of the disease is not fully...
- Rationing research. D.L. // Common Cause Magazine;Winter95, Vol. 21 Issue 4, p6
Presents information on the Huntington's diseases. When it starts to affect the body; Sufferers awareness; Huntington's research funding; Progress; Impact of the disease on the life of Betty Lichtenberg.
- To catch a killer gene. Miller, Susan Katz // New Scientist;4/24/93, Vol. 138 Issue 1870, p37
Discusses the discovery of the gene that causes Huntington's disease. Statistics on people with the disease; Research by Nancy Wexler; Difficulty of the search for the Huntington's gene; Normal function of the gene; Effects of mutation; Finding a cure.