Stem cell decision time
- Enhancing humanity? Shriver Jr., Donald W. // Christian Century;03/07/2001, Vol. 118 Issue 8, p4
Reports on the meeting that was premised on the assumption that genetic science concerns the relations of a remote human past to a remote human future. View of Chinese participants and Western policymakers about intervention in human stem cells; Concerns of molecular biology professor, Xu Zhi...
- A twist of fate. Blau, Helem M. // Nature;10/3/2002, Vol. 419 Issue 6906, p437
Examines the possibility that stem-cell fusion can be a means to reprogram cells for a different function in adulthood. Laboratory production of stable heterokaryons; Genetic reprogramming in different cell systems; Genetic alteration of bone-marrow derived cells to deliver genes to specific...
- Does anybody really care about this stuff? Crain, Keith // Crain's Detroit Business;8/13/2001, Vol. 17 Issue 34, p8
Comments on the controversy concerning the use of stem cells in genetics research in the United States. Continuation of stem cell research regardless of what Congress or the President of the U.S. may think of the process; Lack of impact of financing concerns on stem cell research.
- Genetic and cellular aspects of the establishment of histocompatible stem cells: information gained from an animal model. // BMC Proceedings;2011 Supplement 4, Vol. 5 Issue S4, p1
The article presents information on the benefits of patient-specific histocompatible stem cells as an alternative for limitations in stem cell engineering. A study was conducted on animal model to help the establishment of histocompatible, autologous stem cells. The study found that genetic...
- TECHNOLOGY: Cre-ative mouse mosaics. Alfred, Jane // Nature Reviews Genetics;Feb2002, Vol. 3 Issue 2, p88
Discusses research being done on a Cre/loxP-based strategy that induced mitotic recombination in mouse embryonic stem cells. Reference to a study by Liu et al, published in the 2002 issue of "Nature Genetics"; Recombination frequencies.
- Retroviral Transduction and Engraftment Ability of Primate Hematopoietic Progenitor and Stem Cells Transduced Under Serum-Free versus Serum-Containing Conditions. Kluge, Kimberley A.; Bonifacino, Aylin C.; Sellers, Stephanie; Agricola, Brian A.; Donahue, Robert E.; Dunbar, Cynthia E. // Molecular Therapy;Mar2002, Vol. 5 Issue 3, p316
The ability to efficiently transduce hematopoietic stem and progenitor cells under serum-free conditions would be desirable for safety and standardization of clinical gene therapy protocols. Using rhesus macaques, we studied the transduction efficiency and engraftment ability of CD34-enriched...
- Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Liang, Gaoyang; He, Jin; Zhang, Yi // Nature Cell Biology;Jun2012, Vol. 14 Issue 6, p649
A correction to the article "Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming" that was published in the April 2012 issue is presented.
- Embryonic Stem Cells: A Perfect Marriage Between Gene Regulation and Regenerative Medicine. P. Zhou; D.H. Ly // Current Topics in Medicinal Chemistry;Feb2003, Vol. 3 Issue 6, p725
The mechanism of mammalian gene regulation is highly complex, involving multiple layers of feedback control loops and dynamic chromatin remodeling. The current approach used to dissect the genetic circuitry of mammalian gene regulation utilizes somatic cells and protein fusion as a means to...
- Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Kunath, Tilo; Gish, Gerald; Lickert, Heiko; Jones, Nina; Pawson, Tony; Rossant, Janet // Nature Biotechnology;May2003, Vol. 21 Issue 5, p559
Gene targeting via homologous recombination in murine embryonic stem (ES) cells has been the method of choice for deciphering mammalian gene function in vivo. Despite improvements in this technology, it still remains a laborious method. Recent advances in RNA interference (RNAi) technology have...