A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome

Kirsch, Ilan R.; Green, Eric D.; Yonescu, Raluca; Strausberg, Robert; Carter, Nigel; Bentley, David; Leversha, Margaret A.; Dunham, Ian; Braden, Valerie V.; Hilgenfeld, Eva; Schuler, Greg; Lash, Alex E.; Shen, Grace L.; Martelli, Maria; Kuehl, W. Michael; Klausner, Richard D.; Ried, Thomas
April 2000
Nature Genetics;Apr2000, Vol. 24 Issue 4, p339
Academic Journal
Discusses the Cancer Chromosome Aberration Project which aims to integrate systematically the cytogenetic and physical maps of the human genome by high-resolution fluorescence in-situ hybridization. Mapping procedure; Analysis of genomic regions associated with chromosome aberrations.


Related Articles

  • Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution. Wienberg, J. // Cytogenetic & Genome Research;2005, Vol. 108 Issue 1-3, p139 

    For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely on morphological features such as banding...

  • The new cytogenetics: blurring the boundaries with molecular biology. Speicher, Michael R.; Carter, Nigel P. // Nature Reviews Genetics;Oct2005, Vol. 6 Issue 10, p782 

    Exciting advances in fluorescence in situ hybridization and array-based techniques are changing the nature of cytogenetics, in both basic research and molecular diagnostics. Cytogenetic analysis now extends beyond the simple description of the chromosomal status of a genome and allows the study...

  • Multicolor FISH in two and three dimensions for clastogenic analyses. Maierhofer, Christine; Jentsch, Isabell; Lederer, Gaby; Fauth, Christine; Speicher, Michael R. // Mutagenesis;Nov2002, Vol. 17 Issue 6, p523 

    Chemicals may induce both numerical and structural aberrations. In addition to these chromosomal mutations, chemicals may render cells genetically unstable, which may result in chromosomal instability. For a detailed analysis, sophisticated approaches at single cell resolution are needed. Such...

  • Karyotype and cytogenetic mapping of 9 classes of repetitive DNAs in the genome of the naked catfish Mystus bocourti (Siluriformes, Bagridae). Weerayuth Supiwong; Thomas Liehr; Cioffi, Marcelo B.; Chaveerach, Arunrat; Kosyakova, Nadezda; Krit Pinthong; Tawatchai Tanee; Alongklod Tanomtong // Molecular Cytogenetics (17558166); 

    Background In the present study, conventional and molecular cytogenetic studies were performed in the naked catfish Mystus bocourti (Siluriformes, Bagridae). Besides the conventional Giemsa staining, fluorescence in situ hybridization (FISH) using nine classes of repetitive DNAs namely 5S and...

  • Simplified method for molecular cytogenetic examination of human sperm cells. Macek Sr., M.; Yurov, Y.; Diblik, J.; Vorsanova, S.; Paulasova, P.; Vilimova, S.; Potuznikova, P. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;2002 Supplement 2, Vol. 4 Issue S2, p48 

    Objective: The basic cytogenetic method for human chromosome preparation was used for fluorescence in-situ hybridization and primed in-situ labelling (PRINS) examination of human sperm cells. Materials/Methods: The sperm cells after liquefaction of the ejaculate were washed in phosphate-buffered...

  • A high-resolution cucumber cytogenetic map integrated with the genome assembly. Jianying Sun; Zhonghua Zhang; Xu Zong; Sanwen Huang; Zongyun Li; Yonghua Han // BMC Genomics;2013, Vol. 14 Issue 1, p1 

    Background: High-resolution cytogenetic map can provide not only important biological information on genome organization but also solid foundation for genetic and genomic research. The progress in the molecular and cytogenetic studies has created the basis for developing the cytogenetic map in...

  • Fluorescence in situ hybridization analyses of hematologic malignancies reveal frequent cytogenetically unrecognized 12p rearrangements. Andreasson, P; Johansson, B; Billström, R; Garwicz, S; Mitelman, F; Höglund, M // Leukemia (08876924);Mar98, Vol. 12 Issue 3, p390 

    Thirty-two hematologic malignancies--nine with cytogenetically identified 12p abnormalities and 23 with whole or partial losses of chromosome 12--were selected for fluorescence in situ hybridization (FISH) investigations of 12p. These analyses revealed structural 12p changes, such as...

  • Is FISH a relevant prognostic tool in myelodysplastic syndromes with a normal chromosome pattern on conventional cytogenetics? A study on 57 patients. Bernasconi, P.; Cavigliano, P. M.; Boni, M.; Calatroni, S.; Klersy, C.; Giardini, I.; Rocca, B.; Crosetto, N.; Caresana, M.; Lazzarino, M.; Bernasconi, C. // Leukemia (08876924);Nov2003, Vol. 17 Issue 11, p2107 

    Conventional cytogenetics (CC) at clinical diagnosis shows a normal karyotype in 40-60% of de novo myelodysplastic syndromes (MDSs). Fluorescence in situ hybridization (FISH) might detect occult aberrations in these patients. Therefore, we have used FISH to check 57 MDS patients who were...

  • Spoken presentations.  // Journal of Medical Genetics;Sep2002 Supplement, Vol. 39, pS30 

    Discusses the abstract of the research paper entitled 'Diagnostic dilemmas in acquired conditions. Does FISH help?,' by Christine Harrison and presented during the British Human Genetics Conference at the University of York in England in September 2002.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics