Synthesis of thietanyl-substituted pyrimidine-2,4( 1H,3H)-dions

Kataev, V.; Meshcheryakova, S.; Lazarev, V.; Kuznetsov, V.
May 2013
Russian Journal of Organic Chemistry;May2013, Vol. 49 Issue 5, p743
Academic Journal
Reactions of 6-methylpyrimidine-2,4(1 H,3 H)-dione or 5-hydroxy-6-methyl-pyrimidine-2,4(1 H,3H)-dione with 2-chloromethylthiirane afforded the corresponding substituted 1-(thietan-3-yl)pyrimidine-2,4(1 H,3 H)-diones. The calculations in the framework of approximations PBE/3z, B3LYP/6-31G++(d,p) and MP2/6-31G++(d,p) showed that the alkylation occurred at the atom N of the pyrimidine ring.


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