TITLE

Enantioselective synthesis of γ-aminobutyric acid derivatives by Ni(II)-catalyzed reaction of diethyl malonate with nitroalkenes

AUTHOR(S)
Reznikov, A.; Golovin, E.; Klimochkin, Yu.
PUB. DATE
May 2013
SOURCE
Russian Journal of Organic Chemistry;May2013, Vol. 49 Issue 5, p663
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new synthetic approach to (3 R)-4-amino-3-methylbutyric acid and [(4 R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide [( R)-phenotropil] has been developed. Asymmetric center with a required configuration has been generated via enantioselective addition of diethyl malonate to 1-nitropropene and β-nitrostyrene, catalyzed by Ni(II) complexes with ( R,R)- and ( S,S)- N,N′-dibenzylcyclohexane-1,2-diamine.
ACCESSION #
88060416

 

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