TITLE

Effect of heart electric stimulation on repolarization of ventricular myocardium of fish and amphibians

AUTHOR(S)
Azarov, J.; Kibler, N.; Vaykshnorayte, M.; Tsvetkova, A.; Kharin, S.; Vityazev, V.; Shmakov, D.
PUB. DATE
March 2013
SOURCE
Journal of Evolutionary Biochemistry & Physiology;Mar2013, Vol. 49 Issue 2, p165
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The distributions of repolarization durations and end of repolarization time were studied on the ventricular epicardium in pikes ( Esox lucius) and frogs ( Rana esculenta) and in the ventricular intramural layers in toads ( Bufo bufo) at the ectopic heart excitation by using method of the synchronous multielectrode cartography (24 unipolar leads). The time of arrival of the excitation wave and the end of repolarization in each lead were determined from the minimum of time derivative of potential at the period of QRS complex and by minimum of T wave, respectively. It has been established that at the ventricle electrostimulation, alongside with deceleration and a change of sequence of myocardium activation, the redistribution occurs of the local durations of repolarization, being longer than in zones of early activation ( p < 0.05). At stimulation, the apicobasal gradient of repolarization is predominantly changed due to electrophysiological processes in the apical areas. In all the studied species, at the ectopic excitation of the heart the sequence of its repolarization repeats the depolarization sequence due to a delay of activation (in fish) and redistribution of repolarization durations (in amphibians).
ACCESSION #
88060389

 

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