TITLE

Influence of the novel histamine H receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice

AUTHOR(S)

Bahi, Amine; Sadek, Bassem; Schwed, Stephan; Walter, Miriam; Stark, Holger

PUB. DATE

July 2013

SOURCE

Psychopharmacology;Jul2013, Vol. 228 Issue 1, p85

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Rationale: Growing evidence supports a role for the central histaminergic system to have a modulatory influence on drug addiction in general and alcohol-use disorders in particular through histamine H receptors (HR). Objective: In the present study, the effects of systemic injection of the newly synthesized HR antagonist ST1283 on ethanol (EtOH) voluntary intake and EtOH-conditioned reward in mice have been investigated. Methods: Oral EtOH, saccharin, and quinine intake was assessed in a two-bottle choice paradigm using escalating concentrations of alcohol or tastant solutions. EtOH-induced place preference (CPP), EtOH-induced locomotor activity, and blood ethanol concentration (BEC) were also measured. Results: Following administration of the HR antagonist (2.5, 5, and 10 mg/kg, i.p.), there was a significant dose-dependent decrease in alcohol consumption and preference. Importantly, vehicle- and ST1283 (5 mg/kg)-treated mice showed similar consumption and preference to increasing concentration of both sweet and bitter tastes. More interestingly, systemic administration of ST1283 inhibited EtOH-CPP and EtOH-enhanced locomotion. This inhibition was blocked when mice were pretreated with the selective HR agonist R-(alpha)-methyl-histamine (10 mg/kg). Finally, vehicle- and ST1283-treated mice had similar BECs. Conclusion: Our results show that ST1283 may decrease voluntary EtOH consumption and EtOH-CPP by altering its reinforcing effects, suggesting a novel role for histamine signaling in regulation of alcoholism. Lastly, the results add to the growing literature on HR modulation in the pharmacotherapy of EtOH addiction.

ACCESSION #

88060304

 

Related Articles

• Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice. Nuutinen, Saara; Lintunen, Minnamaija; Vanhanen, Jenni; Ojala, Tiia; Rozov, Stanislav; Panula, Pertti // Neuropsychopharmacology;Sep2011, Vol. 36 Issue 10, p2030 

  Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related behaviors using H3R knockout (KO) mice and ligands. H3R KO mice consumed less alcohol than wild-type (WT) mice in a...

• BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Kreifeldt, Max; Le, David; Treistman, Steven N.; Koob, George F.; Contet, Candice // Frontiers in Integrative Neuroscience;Dec2013, Vol. 7, p1 

  Large conductance calcium-activated potassium (BK) channels play a key role in the control of neuronal activity. Ethanol is a potent activator of BK channel gating, but how this action may impact ethanol drinking still remains poorly understood. Auxiliary β subunits are known to modulate...

• Alterations in Ethanol-Induced Behaviors and Consumption in Knock-In Mice Expressing Ethanol-Resistant NMDA Receptors. den Hartog, Carolina R.; Beckley, Jacob T.; Smothers, Thetford C.; Lench, Daniel H.; Holseberg, Zack L.; Fedarovich, Hleb; Gilstrap, Meghin J.; Homanics, Gregg E.; Woodward, John J. // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

  Ethanol's action on the brain likely reflects altered function of key ion channels such as glutamatergic N-methyl-D-aspartate receptors (NMDARs). In this study, we determined how expression of a mutant GluN1 subunit (F639A) that reduces ethanol inhibition of NMDARs affects ethanol-induced...

• GABAA Receptors Containing ρ1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. Blednov, Yuri A.; Benavidez, Jillian M.; Black, Mendy; Leiter, Courtney R.; Osterndorff-Kahanek, Elizabeth; Johnson, David; Borghese, Cecilia M.; Hanrahan, Jane R.; Johnston, Graham A. R.; Chebib, Mary; Harris, R. Adron // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

  GABAA receptors consisting of ρ1, ρ2, or ρ3 subunits in homo- or hetero-pentamers have been studied mainly in retina but are detected in many brain regions. Receptors formed from ρ1 are inhibited by low ethanol concentrations, and family-based association analyses have linked ρ...

• Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice. Pastor, Raúl; Reed, Cheryl; Burkhart-Kasch, Sue; Li, Na; Sharpe, Amanda; Coste, Sarah; Stenzel-Poore, Mary; Phillips, Tamara // Psychopharmacology;Nov2011, Vol. 218 Issue 1, p169 

  Rationale: Exposure to stressors promotes ethanol (EtOH) consumption and enhances drug craving during abstinence. Corticotropin-releasing factor (CRF), and in particular, CRF actions via type 1 CRF receptors (CRF) are critical in behavioral responses to stressors. CRF play a role in EtOH-induced...

• Operant, oral alcoholic beer self-administration by C57BL/6J mice: effect of BHF177, a positive allosteric modulator of GABA receptors. Orrù, Alessandro; Fujani, Daniele; Cassina, Chiara; Conti, Mirko; Clemente, Angelo; Cervo, Luigi // Psychopharmacology;Aug2012, Vol. 222 Issue 4, p685 

  Rationale: With its high palatability, near-beer has been successfully used in rats as a vehicle to induce ethanol oral self-administration. Objectives: The study aimed to develop an operant model of oral alcoholic beer self-administration promoting a stable intake of pharmacologically relevant...

• Reduction of excessive alcohol drinking by a novel GABA receptor positive allosteric modulator ADX71441 in mice. Hwa, Lara; Kalinichev, Mikhail; Haddouk, Hasnaà; Poli, Sonia; Miczek, Klaus // Psychopharmacology;Jan2014, Vol. 231 Issue 2, p333 

  Rationale: A promising pharmacotherapy for alcohol use disorders has been positive allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABA R) since GABA R PAMs reduce ethanol drinking and self-administration in rodents. Objective: The current studies investigated a novel,...

• Reduction of ethanol intake by corticotropin-releasing factor receptor-1 antagonist in 'heavy-drinking' mice in a free-choice paradigm. Correia, Diego; Martynhak, Bruno; Pereira, Marcela; Siba, Isadora; Ribeiro, Andrea; Camarini, Rosana; Boerngen-Lacerda, Roseli // Psychopharmacology;Aug2015, Vol. 232 Issue 15, p2731 

  Rationale: We hypothesized that the corticotropin-releasing factor (CRF) system is hyperresponsive in animals with high ethanol intake, which exhibits a reduction of ethanol intake when administered with a CRF receptor antagonist. Methods: Outbred Swiss mice were subjected to a long-term,...

• Ontogeny of the stimulant and sedative effects of ethanol in male and female Swiss mice: gradual changes from weaning to adulthood. Quoilin, Caroline; Didone, Vincent; Tirelli, Ezio; Quertemont, Etienne // Psychopharmacology;Dec2010, Vol. 212 Issue 4, p501 

  Rationale: The adolescent period is characterized by a specific sensitivity to the effects of alcohol, which is believed to contribute to the enhanced risks of alcohol dependence when drinking is initiated early during adolescence. In adolescent rodents, while the reduced sensitivity to the...

Read the Article