TITLE

In vivo binding of the dopamine-1 receptor PET tracers [C]NNC112 and [C]SCH23390: a comparison study in individuals with schizophrenia

AUTHOR(S)
Poels, Eline; Girgis, Ragy; Thompson, Judy; Slifstein, Mark; Abi-Dargham, Anissa
PUB. DATE
July 2013
SOURCE
Psychopharmacology;Jul2013, Vol. 228 Issue 1, p167
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Rationale: A deficit in dopamine-1 (D) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D receptor tracers used in previous reports, [C]SCH23390 and [C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [C]SCH23390 and [C]NNC112. Results: [C]SCH23390 and [C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [C]SCH23390 and [C]NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.
ACCESSION #
88060295

 

Related Articles

  • Practice, learning, and the likelihood of making an error: how task experience shapes physiological response in patients with schizophrenia. Holcomb, Henry H. // Psychopharmacology;2004, Vol. 174 Issue 1, p136 

    Rationale. Behavioral and functional neuroimaging research has extensively documented the ways in which people with schizophrenia perform poorly on cognitive tasks and exhibit abnormal brain activity patterns when engaged in those tasks, even when their performance is adjusted to become similar...

  • Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies. Rieck, Richard W.; Ansari, M.S.; Whetsell Jr, William O.; Deutch, Ariel Y.; Kessler, Robert M. // Neuropsychopharmacology;Feb2004, Vol. 29 Issue 2, p362 

    The distribution of dopamine (DA) D2-like receptors in the human thalamus was studied using in vitro autoradiographic techniques and in vivo positron emission tomography in normal control subjects. [125I]Epidepride, which binds with high affinity to DA D2 and D3 receptors, was used in...

  • Dopamine D occupancy of ziprasidone across a day: a within-subject PET study. Suzuki, Takefumi; Graff-Guerrero, Ariel; Uchida, Hiroyuki; Remington, Gary; Caravaggio, Fernando; Borlido, Carol; Pollock, Bruce; Mulsant, Benoit; DeLuca, Vincenzo; Ismail, Zahinoor; Mamo, David // Psychopharmacology;Jul2013, Vol. 228 Issue 1, p43 

    Rationale: Ziprasidone is an atypical antipsychotic recommended to be administered twice daily. Objectives: The purpose of this study was to investigate whether occupancy of the dopamine D receptors by ziprasidone is maintained across a day employing a within subject design. Methods: Positron...

  • The Striatal and Extrastriatal D2/D3 Receptor-Binding Profile of Clozapine in Patients with Schizophrenia. Gründer, Gerhard; Landvogt, Christian; Vernaleken, Ingo; Buchholz, Hans-Georg; Ondracek, Jasmin; Siessmeier, Thomas; Härtter, Sebastian; Schreckenberger, Mathias; Stoeter, Peter; Hiemke, Christoph; Rösch, Frank; Wong, Dean F; Bartenstein, Peter // Neuropsychopharmacology;May2006, Vol. 31 Issue 5, p1027 

    Positron emission tomography (PET) studies reveal that clozapine at clinically used doses occupies less than 60% of D2/D3 dopamine receptors in human striatum. Here, the occupancy of D2/D3 dopamine receptors by clozapine in patients with schizophrenia was determined to test the hypothesis that...

  • Åžizofreni Hastalarında Ä°lk Atakta P300 Bulguları ile Nörolojik Silik Ä°ÅŸaretler Arasındaki Ä°liÅŸki. Lapsekili, Nergis; Uzun, Özcan; Sütçigil, Levent; Ak, Mehmet; Yücel, Mehmet // Dusunen Adam: Journal of Psychiatry & Neurological Sciences;Sep2011, Vol. 24 Issue 3, p167 

    Objective: In this study, the relationship between neurological soft signs and P300 components was explored in patients with schizophrenia. Method: 22 first-episode schizophrenia patients who were evaluated according to DSM-IV criteria and whose disease lasted at least six months, and a group of...

  • Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania. Morice, Rodney // British Journal of Psychiatry;Jul90, Vol. 157, p50 

    The ability to shift cognitive set, which is probably subserved, at least in part, by the pre-frontal cortex, was determined for schizophrenic, bipolar (manic) and control subjects, using the Wisconsin Card Sorting Test (WCST). The schizophrenic and manic subjects both demonstrated poor...

  • A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. Kreisl, William C; Jenko, Kimberly J; Hines, Christina S; Hyoung Lyoo, Chul; Corona, Winston; Morse, Cheryl L; Zoghbi, Sami S; Hyde, Thomas; Kleinman, Joel E; Pike, Victor W; McMahon, Francis J; Innis, Robert B // Journal of Cerebral Blood Flow & Metabolism;Jan2013, Vol. 33 Issue 1, p53 

    Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or...

  • Functional significance of central D1 receptors in cognition: beyond working memory. Takahashi, Hidehiko; Yamada, Makiko; Suhara, Tetsuya // Journal of Cerebral Blood Flow & Metabolism;Jul2012, Vol. 32 Issue 7, p1248 

    The role of dopamine D1 receptors in prefrontal cortex function, including working memory, is well acknowledged. However, relatively little is known about their role in other cognitive or emotional functions. We measured both D1 and D2 receptors in the brain using positron emission tomography in...

  • An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia. Rybakowski, J. K.; Borkowska, A.; Czerski, P. M.; Kapelski, P.; Dmitrzak-Weglarz, M.; Hauser, J. // Journal of Neural Transmission;Nov2005, Vol. 112 Issue 11, p1575 

    Dopamine (DA), an important neurotransmitter in prefrontal cortex (PFC), is involved in the pathogenesis of schizophrenia. The aim of the study was to test an association between common polymorphism of genes for DA receptors DRD1, DRD2, DRD3, DRD4, and performance on the Wisconsin Card Sorting...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics