In vivo binding of the dopamine-1 receptor PET tracers [C]NNC112 and [C]SCH23390: a comparison study in individuals with schizophrenia

Poels, Eline; Girgis, Ragy; Thompson, Judy; Slifstein, Mark; Abi-Dargham, Anissa
July 2013
Psychopharmacology;Jul2013, Vol. 228 Issue 1, p167
Academic Journal
Rationale: A deficit in dopamine-1 (D) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D receptor levels in individuals with schizophrenia are mixed. Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D receptor tracers used in previous reports, [C]SCH23390 and [C]NNC112, may have contributed to these discrepancies reported in the literature. Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [C]SCH23390 and [C]NNC112. Results: [C]SCH23390 and [C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed. Conclusions: The results of this study suggest that differences in the binding of [C]SCH23390 and [C]NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.


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