Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer

Yunusova, N.; Spirina, L.; Kondakova, I.; Kolomiets, L.; Chernyshova, A.; Koval, V.; Nedosekov, V.; Savenkova, O.
May 2013
Biology Bulletin;May2013, Vol. 40 Issue 3, p253
Academic Journal
We have examined for the first time the relationship between the expression of PAPP-A metalloproteinase and insulin-like growth factors (IGF-I, IGF-II, VEGF) and transcription factors (NF-κB, HIF-1) playing an important role in pathogenesis of cancer. We also demonstrated a positive association between the level of PAPP-A metalloproteinase and the level of growth (VEGF and IGF-I) and transcription factors (NF-κB p50, NF-κB p65, HIF-1α). The current findings suggest an important role of PAPP-A in regulation of bioavailability of IGF-I, VEGF, activated forms of NF-κB, and α-subunits of HIF-1 in endometrial tumors.


Related Articles

  • Overexpression of FoxM1 is associated with tumor progression in patients with clear cell renal cell carcinoma. Yi-Jun Xue; Ri-Hai Xiao; Da-Zhi Long; Xiao-Feng Zou; Xiao-Ning Wang; Guo-Xi Zhang; Yuan-Hu Yuan; Geng-Qing Wu; Jun Yang; Yu-Ting Wu; Hui Xu; Fo-Lin Liu; Min Liu // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p200 

    Background: Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression. Numerous studies have documented that FoxM1 has multiple functions in tumorigenesis and its elevated levels are frequently associated with cancer progression. The present...

  • Environmental impact. Croager, Emma // Nature Reviews Cancer;Oct2003, Vol. 3 Issue 10, p713 

    The article discusses tumorigenesis. It has been shown that hypoxia-responsive transcription factor, HIF-1α promotes tumor growth by initiating angiogenesis. Overexpression of HIF-1α is correlated with the progression of astrocytoma, an oxygen dependant early stage brain tumour. It was...

  • Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice. Caso, Giuseppe; Barry, Catherine; Patejunas, Gerald // Journal of Hematology & Oncology;2009, Vol. 2, p1 

    Background: Early growth response-1 (Egr-1) is an immediate-early transcription factor inducible in the vasculature in response to injury, shear stress, and other stimuli. Mice lacking Egr-1 have a profound deficit in the ability to recover from femoral artery ligation, suggesting a role in...

  • Role of RUNX3 in Suppressing Metastasis and Angiogenesis of Human Prostate Cancer. Chen, Feifei; Wang, Meng; Bai, Jin; Liu, Qinghua; Xi, Yaguang; Li, Wang; Zheng, Junnian // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    RUNX3 (runt-related transcription factor-3) has been reported to suppress tumor tumorigenesis and metastasis in different human cancers. In this study, we used tissue microarray (TMA) to determine the significance of RUNX3 in prostate cancer progession. Our results showed ectopic expression of...

  • Clinical Approaches Toward Tumor Angiogenesis: Past, Present and Future. Fujita, Yasuyuki; Abe, Riichiro; Shimizu, Hiroshi // Current Pharmaceutical Design;12/21/2008, Vol. 14 Issue 36, p3820 

    Angiogenesis is a complex process which is critical for the growth, invasion, and metastasis of tumors. In the past ten years numerous new agents have been developed as angiogenesis inhibitors. Angiogenesis inhibitors can be classified by their targeted area of the angiogenic process; (1) VEGF...

  • Antivascular Endothelial Growth Factor Monoclonal Antibody Therapy: A Promising Paradigm in Colorectal Cancer. Franson, Paula J.; Lapka, Denise V. // Clinical Journal of Oncology Nursing;Feb2005, Vol. 9 Issue 1, p55 

    Angiogenesis plays an important role in tumor growth and development. Vascular endothelial growth factor (VEGF) is one of the most potent proangiogenic factors and therefore is an ideal target in colorectal cancer therapy. Bevacizumab (Avastinâ„¢, Genentech, Inc., South San Francisco,CA) is...

  • VEGF-null cells require PDGFR a signaling-mediated stromal fibroblast recruitment for tumorigenesis. Jianying Dong; Grunstein, Jeremy; Tejada, Max; Peale, Frank; Frantz, Gretchen; Wei-Ching Liang; Wei Bai; Lanlan Yu; Kowalski, Joe; Xiaohuan Liang; Fuh, Germaine; Gerber, Hans-Peter; Ferrara, Napoleone // EMBO Journal;7/21/2004, Vol. 23 Issue 14, p2800 

    We generated VEGF-null fibrosarcomas from VEGF-loxP mouse embryonic fibroblasts to investigate the mechanisms of tumor escape after VEGF inactivation. These cells were found to be tumorigenic and angiogenic in vivo in spite of the absence of tumor-derived VEGF. However, VEGF derived from host...

  • Downregulation of interleukin-7 and hepatocyte growth factor in the thymic microenvironment is associated with thymus involution in tumor-bearing mice. Carrio, Roberto; Altman, Norman H.; Lopez, Diana M. // Cancer Immunology, Immunotherapy;Dec2009, Vol. 58 Issue 12, p2059 

    During mammary tumorigenesis, there is a profound thymic involution associated with severe depletion of the most abundant subset of thymocytes, CD4+CD8+ immature cells, and an early arrest in at least two steps of T cell differentiation. Thymic atrophy that is normally related with aging has...

  • A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 "multi-points priming" mechanisms in vitro and in vivo. Xin-Ping Li; Wei Jing; Jian-Jun Sun; Zhong-Yan Liu; Jing-Tao Zhang; Wei Sun; Wei Zhu; Yue-Zu Fan // BMC Cancer;Jul2015, Vol. 15 Issue 1, p1 

    Background: Tumor lymphangiogenesis plays an important role in promoting growth and metastasis of tumors, but no antilymphangiogenic agent is used clinically. Based on the effect of norcantharidin (NCTD) on lymphangiogenesis of human lymphatic endothelial cells (LECs), we firstly investigated...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics