TITLE

Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer

AUTHOR(S)
Yunusova, N.; Spirina, L.; Kondakova, I.; Kolomiets, L.; Chernyshova, A.; Koval, V.; Nedosekov, V.; Savenkova, O.
PUB. DATE
May 2013
SOURCE
Biology Bulletin;May2013, Vol. 40 Issue 3, p253
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have examined for the first time the relationship between the expression of PAPP-A metalloproteinase and insulin-like growth factors (IGF-I, IGF-II, VEGF) and transcription factors (NF-κB, HIF-1) playing an important role in pathogenesis of cancer. We also demonstrated a positive association between the level of PAPP-A metalloproteinase and the level of growth (VEGF and IGF-I) and transcription factors (NF-κB p50, NF-κB p65, HIF-1α). The current findings suggest an important role of PAPP-A in regulation of bioavailability of IGF-I, VEGF, activated forms of NF-κB, and α-subunits of HIF-1 in endometrial tumors.
ACCESSION #
88059970

 

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