Is there a Role for Immunological Mechanisms in Etiopathogenesis of Obsessive Compulsive Disorder?

Rao, Naren P.; Reddy, M. S.; Reddy, Janardhan Y. C.
January 2013
Indian Journal of Psychological Medicine;Jan-Mar2013, Vol. 35 Issue 1, p1
Academic Journal
The article discusses the role of immunological mechanisms in etiopathogenesis of obsessive compulsive disorder (OCD). It states that OCD is a neuropsychiatric disorder with a prevalence of about 2%. It recognizes that selective serotonin reuptake inhibitors (SSRI) abnormality may be the final common pathway and other mechanisms that may also play important roles in the etiopathogenesis of OCD though they are the mainstay of treatment. It suggests that immunologicalabnormalities have a role in the pathogenesis of OCD based on most research. It examines OCD as a unitary entity and have failed to identify a single common etiopathogenic mechanism.


Related Articles

  • Compulsive Personality as Predictor of Response to Serotonergic Antidepressants. Pollitt, John; Tyrer, Peter // British Journal of Psychiatry;Dec92, Vol. 161, p836 

    The article comments on "Compulsive personality as predictor of response to serotonergic antidepressants," a 1991 study by M. Ansseau, B. Troisfontaines, P. Papart and colleagues, published in the volume 303 of this journal. The study postulated that there may be a link between depression and...

  • Pharmacotherapies in the management of obsessive-compulsive disorder. Blier, Pierre; Habib, Rami; Flament, Martine F. // Canadian Journal of Psychiatry;Jun2006, Vol. 51 Issue 7, p417 

    Few medications are effective in treating obsessive-compulsive disorder (OCD). As monotherapy, only potent serotonin (5-HT) reuptake inhibitors (SRIs) consistently exert an intrinsic therapeutic action in OCD. Their use in OCD, however, differs from their use in depression. This paper first...

  • Lack of Evidence For Association Between Serotonin Transporter Gene Polymorphism and Obsessive Compulsive Disorder. Acar, Şenel Tot; Erdal, M. Emin; Yazıcı, Kemal; Yazıcı, Aylin Ertekin; Başterzi, Ayşe Devrim // Yeni Symposium;2010, Vol. 48 Issue 1, p32 

    Objective: Although it is believed that obsessive compulsive disorder [OCD] has a genetic component, the type and number of genes involved in this disorder have not been understood entirely. The serotonin transporter [5-HTT] gene has been considered a candidate gene for OCD. The aim of this...

  • Development and Psychometric Evaluation of the Treatment-Emergent Activation and Suicidality Assessment Profile. Reid, Jeannette M.; Storch, Eric A.; Murphy, Tanya K.; Bodzin, Danielle; Mutch, P. Jane; Lehmkuhl, Heather; Aman, Michael; Goodman, Wayne // Child & Youth Care Forum;Apr2010, Vol. 39 Issue 2, p113 

    Although effective in treating a range of childhood psychiatric conditions, selective serotonin reuptake inhibitors (SSRI) have been implicated in the induction of an "activation syndrome" (characterized by symptoms of irritability, restlessness, emotional labiality, etc.) that may represent an...

  • Still Struggling: Characteristics of Youth With OCD Who are Partial Responders to Medication Treatment. Freeman, J.; Sapyta, J.; Garcia, A.; Fitzgerald, D.; Khanna, M.; Choate-Summers, M.; Moore, P.; Chrisman, A.; Haff, N.; Naeem, A.; March, J.; Franklin, M. // Child Psychiatry & Human Development;Aug2011, Vol. 42 Issue 4, p424 

    The primary aim of this paper is to examine the characteristics of a large sample of youth with OCD who are partial responders (i.e., still have clinically significant symptoms) to serotonin reuptake inhibitor (SRI) medication. The sample will be described with regard to: demographics, treatment...

  • Los antidepresivos inhibidores selectivos de recaptura de serotonina (ISRS, ISR-5HT). Chávez- León, Enrique; Patricia Ontiveros Uribe, Martha; Serrano Gómez, Carlos // Salud Mental;jul/ago2008, Vol. 31 Issue 4, p307 

    Depression is a frequent mental disorder in the general population. Approximately 3.7% of the population will suffer a major depressive episode throughout life. Pharmacological treatment with selective serotonin receptor inhibitors (SSRIs) is useful to treat this condition and other mental...

  • Citalopram concentrations and response in obsessive-compulsive disorder. Preliminary results. Bareggi, Silvio R.; Bianchi, L.; Cavallaro, R.; Gervasoni, M.; Siliprandi, F.; Bellodi, L. // CNS Drugs;2004, Vol. 18 Issue 5, p329 

    Objective: Citalopram, a highly potent SSRI, is effective in the treatment of depressive disorders and obsessive-compulsive disorder (OCD); however, very few studies have reported concentration-effect relationships for SSRIs. The aim of this study was to investigate the relationship...

  • Are SSRIs Effective for Treating OCD? Kripke, Clarrisa // American Family Physician;5/1/2008, Vol. 77 Issue 9, p1252 

    The article looks at the effectiveness of selective serotonin reuptake inhibitors (SSRIs) for treating obsessive-compulsive disorder (OCD). Accordingly, 17 studies that included 3,097 adults with OCD were examined, comparing placebo with fluoxetine, fluvoxamine, sertraline, paroxetine,...

  • sertraline. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p684 

    An encyclopedia entry for "sertraline," which refers to a selective serotonin reuptake inhibitor drug used to cure depression and obsessive-compulsive disorder, is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics