TITLE

Active penetration of Trypanosoma cruzi into host cells: historical considerations and current concepts

AUTHOR(S)
de Souza, Wanderley; Ulisses de Carvalho, Tecia M.
PUB. DATE
January 2013
SOURCE
Frontiers in Immunology;Jan2013, Vol. 4, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the present short review, we analyze past experiments that addressed the interactions of intracellular pathogenic protozoa (Trypanosoma cruzi,Toxoplasma gondii, and Plasmodium) with host cells and the initial use of the term active penetration to indicate that a protozoan "crossed the host cell membrane, penetrating into the cytoplasm." However, the subsequent use of transmission electron microscopy showed that, for all of the protozoans and cell types examined, endocytosis, classically defined as involving the formation of a membrane-bound vacuole, took place during the interaction process. As a consequence, the recently penetrated parasites are always within a vacuole, designated the parasitophorous vacuole (PV).
ACCESSION #
88043799

 

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