Tumor protein 53-induced nuclear protein 1 enhances p53 function and represses tumorigenesis

Shahbazi, Jeyran; Lock, Richard; Tao Liu
May 2013
Frontiers in Genetics;May2013, Vol. 3, p1
Academic Journal
No abstract available.


Related Articles

  • Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration. Yeudall, W.Andrew; Vaughan, Catherine A.; Miyazaki, Hiroshi; Ramamoorthy, Mahesh; Choi, Mi-Yon; Chapman, Christopher G.; Wang, Huixin; Black, Elena; Bulysheva, Anna A.; Deb, Swati Palit; Windle, Brad; Deb, Sumitra // Carcinogenesis;Feb2012, Vol. 33 Issue 2, p442 

    The role of dominant transforming p53 in carcinogenesis is poorly understood. Our previous data suggested that aberrant p53 proteins can enhance tumorigenesis and metastasis. Here, we examined potential mechanisms through which gain-of-function (GOF) p53 proteins can induce motility. Cells...

  • Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-κB- and p53-regulated gene targets. McTavish, N.; Copeland, L. A.; Saville, M. K.; Perkins, N. D.; Spruce, B. A. // Cell Death & Differentiation;Sep2007, Vol. 14 Issue 9, p1700 

    The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor κB (NF-κB), and their potential impact on tumorigenesis and response to tumor therapy are well recognized. The capacity of the RelA(p65) subunit of NF-κB to specify a pro-apoptotic...

  • HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels. Ying Wang; Debatin, Klaus-Michael; Hug, Hubert // BMC Molecular Biology;2001, Vol. 2, p8 

    Background: HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of homeodomain containing transcription factors. Results and Conclusions: We show here that HIPK2 activates transcription...

  • Hetero-oligomerization does not compromise 'gain of function' of tumor-derived p53 mutants. Deb, Debabrita; Scian, Mariano; Roth, Katherine E.; Wei Li; Keiger, Jane; Chakraborti, Abhay Sankar; Deb, Swati Palit; Deb, Sunitra // Oncogene;1/10/2002, Vol. 21 Issue 2, p176 

    Deals with a study which examined whether the transactivation function of tumor-derived p53 mutant proteins is sufficient to induce tumorigenesis. Information on tumor-derived mutant p53-281G; Methodology of the study; Results and discussion.

  • P53 inhibition by the LANA protein of KSHV protects against cell death. Friborg Jr., Jacques; Wing-pui Kong // Nature;12/23/1999, Vol. 402 Issue 6764, p889 

    Shows that latency-associated nuclear antigen (LANA) interacts with the tumor suppressor protein p53 and represses its transcriptional activity. Ability of the viral gene to inhibit the ability of p53 to induce cell death; Contribution of LANA to viral persistence and oncogenesis in Kaposi's...

  • Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression. Ahn, J; Ko, M; Lee, C; Kim, J; Yoon, H; Seong, R H // Oncogene;1/27/2011, Vol. 30 Issue 4, p445 

    Some subunits of the SWI/SNF complex function as tumor suppressors. However, underlying mechanisms are still incompletely defined. Here, we show that Srg3, a mouse homolog of BAF155 that function as a core subunit of this complex, suppresses tumorigenesis in vivo. DNA damage signals promoted...

  • p53 de-ubiquitination: at the edge between life and death. Salomoni, Paolo; Pandolfi, Pier Paolo // Nature Cell Biology;Jun2002, Vol. 4 Issue 6, pE152 

    Reports on the stabilization of the tumor suppressor protein p53 by the de-ubiquitination enzyme herpes-virus-associated-ubiquitin-specific protease (HAUSP) which localizes to the promyelocytic leukemia nuclear body. Finding that the pro-apoptotic activity of p53 is also induced by HAUSP;...

  • hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial–mesenchymal transition through inhibition of Slug transcription. Wen, Fan-Chih; Chang, Tsai-Wang; Tseng, Yau-Lin; Lee, Janq-Chang; Chang, Ming-Chung // Carcinogenesis;Jul2014, Vol. 35 Issue 7, p1481 

    Senescence and epithelial–mesenchymal transition (EMT) have opposing roles in tumor progression, in that, one is a barrier against tumorigenesis, whereas the other is required for invasive malignancies. Here, we report that the DNA damage response (DDR) protein hRAD9 contributes to...

  • DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Fu, K; Ren, H; Wang, Y; Fei, E; Wang, H; Wang, G // Oncogene;3/8/2012, Vol. 31 Issue 10, p1311 

    DJ-1 was initially identified as an oncogene product involved in human tumorigenesis in cooperation with Ras. Increased DJ-1 expression is associated with tumorigenesis in many cancers, whereas the loss of DJ-1 function is linked to an autosomal recessive form of Parkinson's disease (PD). It has...

  • Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro. Serres, M P; Zlotek-Zlotkiewicz, E; Concha, C; Gurian-West, M; Daburon, V; Roberts, J M; Besson, A // Oncogene;6/23/2011, Vol. 30 Issue 25, p2846 

    p27Kip1 (p27) can have opposing roles during malignant transformation depending on cellular context: on one hand it functions as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (CDK) activity in the nucleus and on the other it may adopt an oncogenic role that is less well...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics