It takes two to tango: Ubiquitin and SUMO in the DNA damage response

Bologna, Serena; Ferrari, Stefano
May 2013
Frontiers in Genetics;May2013, Vol. 3, preceding p1
Academic Journal
No abstract available.


Related Articles

  • DNA repair: A heavyweight joins the fray. Boulton, Simon J. // Nature;12/17/2009, Vol. 462 Issue 7275, p857 

    The article discusses the study on the use ubiquitin-related protein called small ubiquitin-like modifier (SUMO) as ubiquitylation regulator in DNA repair. It notes that the subcellular localization of SUMO-pathway components in mammalian cells have been analyzed to investigate the involvement...

  • The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Morris, Joanna R.; Boutell, Chris; Keppler, Melanie; Densham, Ruth; Weekes, Daniel; Alamshah, Amin; Butler, Laura; Galanty, Yaron; Pangon, Laurent; Kiuchi, Tai; Ng, Tony; Solomon, Ellen // Nature;12/17/2009, Vol. 462 Issue 7275, p886 

    Mutations in BRCA1 are associated with a high risk of breast and ovarian cancer. BRCA1 participates in the DNA damage response and acts as a ubiquitin ligase. However, its regulation remains poorly understood. Here we report that BRCA1 is modified by small ubiquitin-like modifier (SUMO) in...

  • SUMO Proteins Locate, Repair DNA Damage, New Study Finds. Kingman, Sharon // BioWorld International;12/23/2009, Vol. 14 Issue 51, p1 

    The article focuses on two studies that discovered a family of proteins called Small Ubiquitin-like Modifier proteins, or SUMO proteins. One study conducted by Jo Morris and colleagues titled "The SUMO Modification Pathway is Involved in the BRCA1 Response to Genotoxic Stress," determined how...

  • RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response. Groocock, Lynda M; Nie, Minghua; Prudden, John; Moiani, Davide; Wang, Tao; Cheltsov, Anton; Rambo, Robert P; Arvai, Andrew S; Hitomi, Chiharu; Tainer, John A; Luger, Karolin; Perry, J Jefferson P; Lazzerini-Denchi, Eros; Boddy, Michael N // EMBO Reports;May2014, Vol. 15 Issue 5, p601 

    The post-translational modification of DNA repair and checkpoint proteins by ubiquitin and small ubiquitin-like modifier ( SUMO) critically orchestrates the DNA damage response ( DDR). The ubiquitin ligase RNF4 integrates signaling by SUMO and ubiquitin, through its selective recognition and...

  • RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Hoege, Carsten; Pfander, Boris; Moldovan, George-Lucian; Pyrowolakis, George; Jentsch, Stefan // Nature;9/12/2002, Vol. 419 Issue 6903, p135 

    Describes the affiliation of the UBC9 small ubiquitin-related modifier (SUMO)-conjugating enzyme with the RAD6 pathway. Modification of proliferating cell nuclear antigen (PCNA) by SUMO and ubiquitin; PCNA as a substrate of the RAD6 pathway; Physical interactions; Functions; Human PCNA...

  • Sumoylation and the DNA Damage Response. Cremona, Catherine A.; Sarangi, Prabha; Zhao, Xiaolan // Biomolecules (2218-273X);Sep2012, Vol. 2 Issue 3, p376 

    The cellular response to DNA damage involves multiple pathways that work together to promote survival in the face of increased genotoxic lesions. Proteins in these pathways are often posttranslationally modified, either by small groups such as phosphate, or by protein modifiers such as ubiquitin...

  • Rpb1 Sumoylation in Response to UV Radiation or Transcriptional Impairment in Yeast. Xuefeng Chen; Baojin Ding; LeJeune, Danielle; Ruggiero, Christine; Shisheng Li // PLoS ONE;2009, Vol. 4 Issue 4, p1 

    Covalent modifications of proteins by ubiquitin and the Small Ubiquitin-like MOdifier (SUMO) have been revealed to be involved in a plethora of cellular processes, including transcription, DNA repair and DNA damage responses. It has been well known that in response to DNA damage that blocks...

  • SUMO: a regulator of gene expression and genome integrity. Müller, Stefan; Ledl, Andreas; Schmidt, Darja // Oncogene;3/15/2004 Review, Vol. 23 Issue 11, p1998 

    Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pathways, including cytokine, Wnt, growth factor and steroid hormone signalling. SUMO frequently restrains the activity...

  • Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Stelter, Philipp; Ulrich, Helle D. // Nature;9/11/2003, Vol. 425 Issue 6954, p188 

    Protein modification by ubiquitin is emerging as a signal for various biological processes in eukaryotes, including regulated proteolysis, but also for non-degradative functions such as protein localization, DNA repair and regulation of chromatin structure. A small ubiquitin-related modifier...

  • The Small Ubiquitin-Like Modifier (SUMO) and SUMO-Conjugating System of Chlamydomonas reinhardtii. Ying Wang; Ladunga, Istvan; Miller, Amy R.; Horken, Kempton M.; Plucinak, Thomas; Weeks, Donald P.; Bailey, Cheryl P. // Genetics;May2008, Vol. 179 Issue 1, p177 

    The availability of the complete DNA sequence of the Chlamydomonas reinhardtii genome and advanced computational biology tools has allowed elucidation and study of the small ubiquitin-like modifier (SUMO) system in this unicellular photosynthetic alga and model eukaryotic cell system. SUMO is a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics