Proinflammatory and immunoregulatory roles of eicosanoids in T cells

Lone, Anna Mari; Taskén, Kjetil
June 2013
Frontiers in Immunology;Jun2013, Vol. 4, p1
Academic Journal
Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs), and thromboxanes (TXAs). The rate-limiting and tightly regulated lipoxygenases control synthesis of LTs while the equally well-controlled cyclooxygenases 1 and 2 generate prostanoids, including PGs, PCs, and TXAs. While many of the classical signs of inflammation such as redness, swelling, pain, and heat are caused by eicosanoid species with vasoactive, pyretic, and pain-inducing effects locally, some eicosanoids also regulateT cell functions. Here, we will revieweicosanoid production inT cell subsets and the inflammatory and immunoregulatory functions of LTs, PGs, PCs, and TXAs in T cells


Related Articles

  • Eicosanoids as Therapeutic Targets in Asthma. Rastogi, P.; McHowat, J. // Letters in Drug Design & Discovery;Nov2006, Vol. 3 Issue 9, p668 

    Asthma is a chronic inflammatory disease of the airways associated with variable airflow obstruction and increased responsiveness to a variety of stimuli. Arachidonic acid metabolites play an important role in the pathophysiology of asthma and in this review we examine the major products of the...

  • Eicosanoids and the modulation of glomerular immune injury. Lianos, Elias A. // Kidney International;Apr1989, Vol. 35 Issue 4, p985 

    Examines the eicosanoids and the modulation of glomerular immune injury. Assessment of the biosynthesis and origin of eicosanoids in experimental and clinical forms of renal immune injury; Role of prostaglandin and thromboxanes in mediating changes in the permeability of the glomerular capillary...

  • ω-3 polyunsaturated fatty acids and the cardiovascular system. Kryzhanovskii, S.; Vititnova, M. // Human Physiology;Jul2009, Vol. 35 Issue 4, p491 

    ω-3 polyunsaturated fatty acids (PUFAs) (alpha-linolenic, eicosapentaenoic, and decosahexaenoic acids) are classified with essential fatty acids and are structural components of the phospholipid bilayer of cell membranes. ω-3 PUFAs incorporated into the phospholipid domain of cell...

  • New Approaches to the Modulation of the Cyclooxygenase-2 and 5-Lipoxygenase Pathways. Gonz�lez-P�riz, A.; Cl�ria, J. // Current Topics in Medicinal Chemistry;Feb2007, Vol. 7 Issue 3, p297 

    The eicosanoid family comprises a number of biologically active lipid mediators involved in the regulation of inflammation and cancer cell growth. Eicosanoid biosynthesis is usually initiated by the release of arachidonic acid (AA) from membrane phospholipids in response to the interaction of a...

  • Protein Regulators of Eicosanoid Synthesis: Role in Inflammation. Homaidan, Fadia R.; Chakroun, Iman; Haidar, Hounaida Abi; El-Sabban, Marwan E. // Current Protein & Peptide Science;Aug2002, Vol. 3 Issue 4, p467 

    A variety of factors contribute to the complex course of inflammation. Microbiological, immunological and toxic agents can initiate the inflammatory response by activating a variety of humoral and cellular mediators. In the early phase of inflammation, excessive amounts of cytokines and...

  • The 2-Series Eicosanoids in Cancer: Future Targets for Glioma Therapy? Moga, Tiberiu; Das, Sunit // Journal of Cancer Therapy;Feb2013, Vol. 4 Issue 1, p338 

    The 2-series eicosanoids are structurally related lipid-soluble hormones synthesized by cyclooxygenase enzymes from arachidonic acid. These compounds have well-established roles in the inflammatory response and the coagulation cascade. More recently, the eicosanoids have garnered attention for...

  • THE PROSTAGLANDINS. Pike, John E. // Journal of Investigative Dermatology;Nov76, Vol. 67 Issue 5 Part 2, p650 

    The prostaglandins (PGs) are a family of naturally occurring, humoral agents characterized by a unique, oxygenated. low-molecular-weight, fatty acid structure incorporating a 5-membered ring. The PGs are formed by nearly all cells from membrane-located stores of polyunsaturated acids bound as...

  • Editorial [Hot Topic: Nitric Oxide and Lipoxins: Role in Inflammation and Defence (Guest Editor: Stefano Fiorucci)]. Fiorucci, Stefano // Inflammation & Allergy - Drug Targets;Apr2006, Vol. 5 Issue 2, p79 

    The focus of this special issue of Inflammation & Allergy - Drug Targets is on anti-inflammation. The inflammatory response protects the body against infection and injury, but can itself become deregulated with deleterious consequences to the host. Several endogenous biochemical pathways...

  • Infectious diseases: Tipping TB off balance. Legg, Katrin // Nature Reviews Drug Discovery;Aug2014, Vol. 13 Issue 8, p576 

    The article focuses on the findings of a study which shows the possibility that manipulating the host eicosanoid balance offer an alternative therapeutic approach to combat Mycobacterium tuberculosis. The increase of eicosanoid prostaglandin E2 (PGE2) along levels of interleukin-1 in the absence...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics