TITLE

Study on Minicell Generation of Lactobacillus acidophilus VTCC-B-871 for Drug Delivery

AUTHOR(S)
Doan Thi Thanh Vinh; Nguyen Tu Hoang Khue
PUB. DATE
May 2013
SOURCE
Journal of Applied Pharmaceutical Science;May2013, Vol. 3 Issue 5, p33
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The practice of developing molecularly targeted drugs to achieve a higher degree of cancer therapy and antibiotic resistance is indispensable. Recently, bacterially derived 400nm sized minicells was reported on the ability of encapsulation with chemotherapeutic drugs. Lactobacillus acidophilus strain participated in the anti-cancer effects and performed the high-level specificity for cancer cell lines. Here we discuss minicells generation of Lactobacillus acidophilus VTCC-B-871 for drug delivery. The present work was the first report on that L. acidophilus VTCC-B-871 formed minicells with highly significant ratio (25 %) in modified MRS broth with fructose 10 g/l carbon source concentration. The minicells were packaged with Paclitaxel (10 µg/ml) and Cephalosporin (10 µg/ml) at different times of incubation (10, 15, 24 hours) at 37°C. As a result, minicells could completely absorbed in 10 hours by detecting the extraction after drug packaged minicells on antimicrobial activities on S. aureus ATCC 25923, E. coli ATCC 9637, Salmonella typhi ATCC 19430, C. albicans ATCC 14053, P . aeruginosa ATCC 27853.
ACCESSION #
88017394

 

Related Articles

  • Minimizing Potential Resistance: The Molecular View. Courvalin, Patrice; Trieu-Cuot, Patrick // Clinical Infectious Diseases;9/15/2001 Supplement 3, Vol. 33, pS138 

    The major contribution of molecular biology to the study of antibiotic resistance has been the elucidation of nearly all biochemical mechanisms of resistance and the routes for dissemination of genetic information among bacteria. In this review, we consider the potential contribution of...

  • The Catastrophic Threat of Antibiotic Resistance. Siew, Adeline // Pharmaceutical Technology Europe;Apr2013, Vol. 25 Issue 4, p6 

    The author discusses the significance of antimicrobial research to prevent the harmful threat of antibiotic resistance.

  • Simple and double microencapsulation of Lactobacillus acidophilus with chitosan using spray drying. FLORES-BELMONT, ISELA A.; PALOU, ENRIQUE; LÓPEZ-MALO, AURELIO; JIMÓNEZ-MUNGUÍA, MARÍA TERESA // International Journal of Food Studies;Oct2015, Vol. 4, p188 

    The aim of this study was to evaluate the survival of Lactobacillus acidophilus that had been simple or double spray dried using chitosan to cause microencapsulation and which had been exposed to model gastrointestinal conditions. In addition, the study also determined the physicochemical...

  • Liver Abscess Due to a Lactobacillus rhamnosus Strain Indistinguishable from L. rhamnosus Strain GG. Rautio, Merja; Jousimies-Somer, Hannele; Kauma, Heikki; Pietarinen, Ilmo; Saxelin, Maila; Tynkkynen, Soile; Koskela, Markku // Clinical Infectious Diseases;5/1/1999, Vol. 28 Issue 5, p1159 

    Reports on a case of a woman patient with severe infection due to a intestinal Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clinical history; Diagnosis; Symptoms; Laboratory findings; Antibiotic therapy.

  • NANOROBOTS: THE FUTURE TREND OF DRUG DELIVERY AND THERAPEUTICS. Reza, Kh. Hussan; Asiwarya, G.; Radhika, G.; Bardalai, Dipankar // International Journal of Pharmaceutical Sciences Review & Resear;Sep/Oct2011, Vol. 10 Issue 1, p60 

    Nanorobotics an advanced submicron device generally made of bio-nanocomponents. The present research work targets in diagnosing, treating and preventing disease improving the human health. The nanorobotics has an eminence future in the drug delivery technology. This review sums up the various...

  • New antibiotics needed as drug resistance continues to grow. Panasevich, Christie L. // Nation's Health;Sep2004, Vol. 34 Issue 7, p8 

    With health providers running short on ammunition in their battle against antibiotic-resistant infections, experts warn that the lack of investment in antibiotic research and development could cost U.S. citizens their health. Joseph R. Dalovisio, president of the Infectious Diseases Society of...

  • INFECTION PREVENTION. Infection Control Update: New Glaxo drug to fight drug resistance.  // Healthcare Purchasing News;Sep2010, Vol. 34 Issue 9, p24 

    The article discusses an announcement by the pharmaceutical manufacturer GlaxoSmithKline Plc that it has created an anti-microbial drug compound that may prevent drug resistance in certain bacteria.

  • Clinical Development of Cationic Antimicrobial Peptides: From Natural to Novel Antibiotics. Hancock, R.E.W.; Patrzykat, A. // Current Drug Targets - Infectious Disorders;Mar2002, Vol. 2 Issue 1, p79 

    Over the past decade, levels of bacterial resistance to antibiotics have risen dramatically and �superbugs� resistant to most or all available agents have appeared in the clinic. Thus there is a growing need to discover and introduce new drugs. One potential source of novel antibiotics...

  • The challenge of multidrug resistance: actual strategies in the development of novel antibacterials. Schmidt, F. R. // Applied Microbiology & Biotechnology;Jan2004, Vol. 63 Issue 4, p335 

    Bacterial resistance against established antibiotics is becoming an increasingly important global healthcare problem. Despite enormous efforts, the number of therapeutically useful compounds that emerge from chemical derivatisation programs, which aim at circumventing mechanisms of resistance,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics