Determination of drotaverine hydrochloride in dosage forms by its quenching effect on the luminescence of terbium complex

Yegorova, Alla; Leonenko, Inna; Aleksandrova, Daria; Scrypynets, Yuliya; Aleksandrova, Aleksandra
May 2013
Journal of Applied Pharmaceutical Science;May2013, Vol. 3 Issue 5, p6
Academic Journal
A new, simple, sensitive luminescence method for the determination of drotaverine hydrochloride is developed and validated. The Drotaverine hydrochloride can remarkably quench the luminescence intensity of the Tb3+ ion in terbium complex with 1-bythyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid-(4-methyl-pyridin-2- yl)-amide (R) in aqueous solutions containing urotropine buffer (pH 7.5) at ?ex=317 nm and ?em=545 nm. Under optimal conditions, the quenching of luminescence intensity is directly proportion to the concentration of Drotaverine hydrochloride in the range of 0.5-300 µg/mL and detection limit is 0.16µg/mL. This method was applied for the determination of Drotaverine hydrochloride in tablets "No-spa".


Related Articles

  • Detrusitol.  // Royal Society of Medicine: Medicines;2002, p194 

    This article presents information on the drug Detrusitol, a proprietary, prescription-only preparation of the anticholinergic tolterodine tartrate. It can be used as an antispasmodic in the treatment of urinary disorders such as incontinence. It is available as tablets.

  • Detrunorm.  // Royal Society of Medicine: Medicines;2002, p194 

    This article presents information on the drug Detrunorm, a proprietary, prescription-only preparation of the anticholinergic propiverine hydrochloride. It can be used as an antispasmodic in the treatment of urinary disorders such as incontinence. It is available as tablets.

  • Novel Luminescent Probe Based on a Terbium(III) Complex for Hemoglobin Determination. Yegorova, A.; Leonenko, I.; Aleksandrova, D.; Scrypynets, Yu.; Antonovich, V.; Ukrainets, I. // Journal of Applied Spectroscopy;Sep2014, Vol. 81 Issue 4, p672 

    We have studied the spectral luminescent properties of Tb(III) and Eu(III) complexes with a number of novel derivatives of oxoquinoline-3-carboxylic acid amides (L-L ). We have observed quenching of the luminescence of 1:1 Tb(III)-L complexes by hemoglobin (Hb), which is explained by resonance...

  • A VALIDATED RP-HPLC METHOD FOR ESTIMATION OF DROTAVERINE HCL IN PHARMACEUTICAL TABLET DOSAGE FORM. Balan, P.; Nimila, I. Carolin; Chundi, Sasirekha; Movva, Vanaja Rani; Rajasekar, S. // International Journal of Pharmacy & Pharmaceutical Sciences;Oct2011, Vol. 3 Issue 4, p77 

    An accurate, sensitive, precise and robust reverse phase HPLC method was developed for the determination of the Drotaverine HCl in pharmaceutical dosage form and validated. Chromatographic separation was conducted on an Hypersil C18 (150 × 4.6 mm), 5µ column from Shimadzu in isocratic...

  • Wrongly Prescribed Half Tablets in a Swiss University Hospital. Arnet, Isabelle; Von Moos, Maya; Hersberger, Kurt E. // International Journal of Clinical Medicine;Dec2012, Vol. 3 Issue 7, p637 

    Background: Prescription of 1/2 tablets is a widespread practice, mainly to achieve dose flexibility and to facilitate swallowing. However, tablet splitting includes several disadvantages, like destruction of galenic formulation, stability problems, and unequal amount of active ingredient that...

  • RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF IMATINIB MESYLATE IN TABLET DOSAGE FORM. Kuna, Arun Kumar; Kumar, Kuna Jagadeesh // International Journal of Pharmacy & Pharmaceutical Sciences;Oct2011 Supplement, Vol. 3, p162 

    An accurate, Precise, Simple and Economical High Performance Liquid Chromatographic method for the estimation of Imatinb mesylate in its tablet dosage form has been developed. The method so developed is Reverse Phase High Performance Liquid Chromatographic method using Hypersil BDS C18 column...

  • Spectrophotometric Simultaneous Estimation of Ranitidine Hydrochloride and Ondansetron hydrochloride from Tablet Formulation. Pillai, S.; Singhvi, I. // Indian Journal of Pharmaceutical Sciences;2007, Vol. 69 Issue 4, p601 

    Three simple, accurate, economical and reproducible UV spectrophotometric methods for simultaneous estimation of two component drug mixture of ranitidine hydrochloride and ondansetron hydrochloride from combined tablet dosage form have been developed. First developed method involves formation...

  • Development and Validation of a Stability-Indicating Capillary Electrophoresis Method for the Determination of Zolpidem Tartrate in Tablet Dosage Form with Positive Confirmation using 2D- and 3D-DAD Fingerprints. AL AZZAM, Khaldun M.; YIT, Lee Kam; SAAD, Bahruddin; SHAIBAH, Hassan // Scientia Pharmaceutica;2014, Vol. 82 Issue 2, p341 

    The aim of the current study was to develop a simple, precise, and accurate capillary zone electrophoresis method for the determination of zolpidem tartrate in tablet dosage form. Separation was conducted in normal polarity mode at 25°C, 22 kV, using hydrodynamic injection for 10 s....

  • Zero Order Spectrophotometric Method for Estimation of Escitalopram Oxalate in Tablet Formulations. Sharma, S.; Rajpurohit, H.; Sonwal, C.; Bhandari, A.; Choudhary, V. R.; Jain, T. // Journal of Young Pharmacists;2010, Vol. 2 Issue 4, p420 

    A new, simple, fast and reliable zero order spectrophotometric method has been developed for determination of Escitalopram Oxalate in bulk and tablet dosage forms. The quantitative determination of drug was carried out using the zero order values (absorbance) measured at 238 nm. Calibration...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics