TITLE

Inhibition of Proinflammatory Cytokines and Mediators by Euphol

AUTHOR(S)
Anjali, Pandey; Sarang, Bani
PUB. DATE
April 2013
SOURCE
Journal of Applied Pharmaceutical Science;Apr2013, Vol. 3 Issue 4, p20
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The anti-inflammatory properties of Euphol (EU) a diterpene, isolated from the rhizomes of the plant Euphorbia acaulis, were evaluated. This study was designed to examine the effects of EU on inflammation in a rat model of pleurisy compared with a steroidal anti-inflammatory drug (DEX, dexamethasone). The rat model of pleurisy was used to evaluate the effectiveness of EU on leukocyte migration, exudation volume, proinflammatory cytokines i.e. Tumor Necrosis factor α (TNFα), Interleukin-1 (IL-1β) and Interleukin-6 (IL-6) as well as on proinflammatory mediators PGE2, nitrite/nitrate levels, and LTB4. Pleurisy was induced by carrageenan (cg ), administered by intra pleural route (i.pl.) and the leukocyte infiltration and inflammatory parameters analyzed 4 h after pleurisy induction. EU (8mg/kg-1, p.o.) treated groups caused significant decrease in the infiltration of neutrophils and exudate volume . There was an observed marked reduction in TNFα, IL-1β and IL-6 levels. Flow cytometric analysis of intracellular TNFα by leukocytes present in pleural exudates showed a significant decrease relative to the total extracellular TNFα inhibition in the pleural fluid. The proinflammatory mediators PGE2, LTB4 release and the nitrite/nitrate levels were remarkably deregulated which are interrelated to TNFα and IL-1β levels.
ACCESSION #
88017342

 

Related Articles

  • Inhibitory effect of ginsenoside-Rd on carrageenan-induced inflammation in rats. Li Wang; Yunxin Zhang; Zhiping Wang; Sijia Li; Guangning Min; Lihua Wang; Jiajia Chen; Junjun Cheng; Yongjie Wu // Canadian Journal of Physiology & Pharmacology;Feb2012, Vol. 90 Issue 2, p229 

    A previous study reported that ginsenoside-Rd reduced the production of tumor necrosis factor-α by inhibiting nuclear factor- κB in lipopolysaccharide-activated N9 microglia in vitro. The aim of the present study was to confirm the anti-inflammatory effects and mechanisms of ginsenoside-Rd...

  • Anti-inflammation Effects of Corn Silk in a Rat Model of Carrageenin-Induced Pleurisy. Wang, Guang-Qiang; Xu, Tao; Bu, Xue-Mei; Liu, Bao-Yi // Inflammation;Jun2012, Vol. 35 Issue 3, p822 

    Pleurisy is an inflammation of the pleural layers that surround the lungs. Despite much research into inflammatory diseases, no drugs with favorable safety profiles are available yet for their treatment. Corn silk has been used in many parts of the world for the treatment of edema, cystitis,...

  • Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. Garbacki, Nancy; Tits, Monique; Angenot, Luc; Damas, Jacques // BMC Pharmacology;2004, Vol. 4, p1 

    Background: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. Results: Pretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.)...

  • Protective effect of gastrin-releasing peptide receptor antagonist in carrageenan-induced pleural inflammation in rats. Petronilho, Fabricia; Souza, Bruna; Vuolo, Francieli; Benetton, César; Streck, Emilio; Roesler, Rafael; Schwartsmann, Gilberto; Dal-Pizzol, Felipe // Inflammation Research;Sep2010, Vol. 59 Issue 9, p783 

    We report the effects of the gastrin-releasing peptide (GRP) receptor antagonist RC-3095 in an acute inflammation model induced by carrageenan. Male Wistar rats received saline or saline containing 2% λ-carrageenan into the pleural cavity, with some also receiving RC-3095 3 mg/kg...

  • Anti-Inflammation of Spirocyclopiperazinium Salt Compound LXM-10 Targeting α7 nAChR and M4 mAChR and Inhibiting JAK2/STAT3 Pathway in Rats. Zhang, Weiwei; Sun, Qi; Gao, Xiaoli; Jiang, Yimin; Li, Runtao; Ye, Jia // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    The present study aims to investigate the therapeutic effects of LXM-10 by intragastric administration in both acute and chronic inflammatory models, and to explore the underlying molecular mechanisms. The results showed that LXM-10 produced significant anti-inflammatory effects on carrageenan...

  • Anti-inflammatory activity of the topical preparation of Valeriana wallichii and Achyranthes aspera leaves. Khuda, Fazli; Iqbal, Zafar; Khan, Ayub; Zakiullah; Nasir, Fazli; Shah, Yasar // Pakistan Journal of Pharmaceutical Sciences;May2013, Vol. 26 Issue 3, p451 

    In vivo and in vitro screening of anti inflammatory activity of Valeriana wallichii and Achyranthes aspera leaves crude extract was performed, using standardized procedures. Methanolic crude extract topical formulation (cream) of Valeriana wallichii and Achyranthes aspera leaves (Family...

  • Anti-inflammatory studies of Barringtonia acutangula (Linn) fruits on wistar rats. Muralidhar, A.; Reddy, C. Sainath; Yadav, A. Someswara; Kedareeswari, J.; Sankaraiah, B.; Thulasamma, L. Rama; Vijayakumar, B.; Varalakshmi, G. // International Journal of Phytomedicine;2013, Vol. 5 Issue 3, p350 

    The study aims to evaluate the anti inflammatory activity of Barringtonia acutangula (Linn) fruit extracts in wistar rats. In this study fruits of Barringtonia acutangula were extracted with ethanol and purified water, these extracts were subjected to preliminary phytochemical analysis to...

  • The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema. Hajhashemi, Valiollah; Minaiyan, Mohsen; Banafshe, Hamid Reza; Mesdaghinia, Azam; Abed, Alireza // Iranian Journal of Basic Medical Sciences;Jul2015, Vol. 18 Issue 7, p654 

    Objective(s): Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain,...

  • Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones. Dhingra, Ashwani Kumar; Chopra, Bhawna; Dass, Rameshwar; Mittal, Sanjeev K. // International Journal of Medicinal Chemistry;1/11/2016, p1 

    In search of novel effective potent therapeutic agents delivered by oral route for inflammation treatment, some novel O-propargylated-N-acetylpyrazole analogs (5a–j) were prepared by treating N-acetylpyrazole (4a–j) derived from 1,3-diarylpropenones (3a–j) with propargyl...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics