TITLE

Synthesis and Antihypertensive Activity of Some Quinazoline Derivatives

AUTHOR(S)
Patel, Harsha U.; Patel, Ravi S.; Patel, Chhaganbhai N.
PUB. DATE
March 2013
SOURCE
Journal of Applied Pharmaceutical Science;Mar2013, Vol. 3 Issue 3, p171
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Quinazoline derivatives have been very well known for Antihypertensive activity. Seven new Quinazoline derivatives are synthesized by three steps. Purity of compound is checked by TLC monitoring. All synthesized compounds are confirmed by UV, IR, Mass and H1NMR. All synthesized compound were screened for a1-adrenergic receptor blocking activity. Amongst all synthesized compounds 4a & 4e showed better activity
ACCESSION #
88017339

 

Related Articles

  • Microwave Promoted Synthesis of Some Schiff Bases. Kulshrestha, Anchal; Baluja, Shipra // Archives of Applied Science Research;2010, Vol. 2 Issue 3, p221 

    Schiff bases have a wide range of applications such as corrosion inhibitor, intermediates in various reactions, in perfumery etc. Some are known to be used in many potential drugs and are known to possess broad spectrum of biological activities such as antiviral, antifungal, antiparasitic,...

  • Sideband intensities in two-dimensional NMR spectra of rotating solids. Herzfeld, Judith; Roberts, James E.; Griffin, Robert G. // Journal of Chemical Physics;1/15/1987, Vol. 86 Issue 2, p597 

    In the presence of magic angle sample spinning (MASS), two-dimensional solid-state NMR spectra of magnetically dilute I=1/2 nuclei split into rotational sidebands spaced at the spinning frequency in both dimensions. The intensities of these sidebands contain information on the sizes and relative...

  • Towards unnatural xylan based polysaccharides: reductive amination as a tool to access highly engineered carbohydrates. Daus, Stephan; Elschner, Thomas; Heinze, Thomas // Cellulose;Aug2010, Vol. 17 Issue 4, p825 

    Low molecular weight xylan was modified at the reducing end with mono and bifunctional amines. Characterization by means of elemental analysis, nmr spectroscopy and mass spectrometry proved the success of the highly selective reaction. Modified xylan containing amino groups at the reducing end...

  • Preface. Atta-ur-Rahman; Zeller, Klaus-Peter // Current Organic Chemistry;Mar2001, Vol. 5 Issue 3, p1l 

    Introduces a series of articles concerning developments in nuclear magnetic resonance spectroscopy, mass spectrometry and liquid chromatography-mass spectrometry. Applications of heteronuclear multiple bond connectivity measurements in structure elucidation of proton deficient molecular...

  • Isotope Exchange and Covalent Modification Strategies for Studying Protein Structure and Function. Shugui Chen; Engen, John R. // Current Analytical Chemistry;Apr2009, Vol. 5 Issue 2, p205 

    Mass spectrometry can be used to obtain information about all levels of protein structure. To gain access to the conformation information found in the tertiary and quaternary structure, various labeling methods have been developed. These methods convert structural information into mass...

  • Metabonomic Studies. Kenney, Beverly; Shockor, John P. // PharmaGenomics;Nov/Dec2003, Vol. 3 Issue 9, p56 

    Introduces a complementary, exact mass liquid chromatography-mass spectrometry (LC-MS) technology for metabonomic studies. Biological concept of metabonomics; Impact of the application of proton nuclear magnetic resonance spectroscopy on metabonomic analysis; Future developments for...

  • Synthesis and antimicrobial activity of aminomethoxy-substituted 1-(ethylthio)heptanes. Mammadbeyli, E.; Jafarov, I.; Ibrahimli, S.; Kyazimova, T.; Alieva, S.; Mamedova, G. // Russian Journal of General Chemistry;Mar2013, Vol. 83 Issue 3, p481 

    The Mannich condensation of 1-(ethylthio)heptane-2-ol, formaldehyde and secondary amines taken in equimolar amounts gives rise to new aminomethoxy-substituted 1-(ethylthio)heptanes in a yield of 70-77%. The structure of the synthesized compounds was proved by the elemental analysis, IR and H NMR...

  • Synthesis, characterization and biological activity of 4-thiazolidinone derivatives containing 1H-pyrazolo[3,4-b]pyridine nucleus. Kundariya, D. S.; Patel, P. K.; Bheshdadia, B. M. // Der Chemica Sinica;2014, Vol. 5 Issue 1, p138 

    The thiazolidinone derivatives substituted at 2- and 3-position are associated with diverse biological activities. Considerable evidence has been accumulated to demonstrate the wide applications of thiazolidinone derivatives and also Pyrazolo[3,4-b]pyridine nucleus have drawn the attention of...

  • New finding of nalbuphine metabolites in men: NMR spectroscopy and UPLC-MS/MS spectrometry assays in a pilot human study. Wang, Hong-Jaan; Hsiong, Cheng-Huei; Pao, Li-Heng; Chang, Wen-Liang; Zhang, Li-Jie; Lin, Min-Jen; Ho, Shung-Tai; Huang, Pei-Wei; Hu, Oliver // Metabolomics;Aug2014, Vol. 10 Issue 4, p709 

    A safe and efficient semi-synthetic narcotic nalbuphine (NAL) which was broadly applied in analgesic therapy has long been considered to eliminate from human body via phase II conjugation. However, up to the present, neither the complete metabolic pathways nor the identified metabolites of NAL...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics