Synthesis and Antihypertensive Activity of Some Quinazoline Derivatives

Patel, Harsha U.; Patel, Ravi S.; Patel, Chhaganbhai N.
March 2013
Journal of Applied Pharmaceutical Science;Mar2013, Vol. 3 Issue 3, p171
Academic Journal
Quinazoline derivatives have been very well known for Antihypertensive activity. Seven new Quinazoline derivatives are synthesized by three steps. Purity of compound is checked by TLC monitoring. All synthesized compounds are confirmed by UV, IR, Mass and H1NMR. All synthesized compound were screened for a1-adrenergic receptor blocking activity. Amongst all synthesized compounds 4a & 4e showed better activity


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