TITLE

Derivative Spectrophotometric Methods for the Determination of Zolpidem Tartrate in Tablets

AUTHOR(S)

Annapurna, M. Mathrusri; Swathi, B.; Chandra, M. Siri; Tulasi, K.

PUB. DATE

November 2012

SOURCE

Journal of Applied Pharmaceutical Science;Nov2012, Vol. 2 Issue 11, p96

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Two simple, precise and accurate first derivative spectrophotometric methods were developed for the determination of Zolpidem Tartrate in pharmaceutical formulations in phosphate buffer pH 6.8 and acetate buffer pH 4.0. Beer's law was obeyed over the concentration range 0.5-20 µg/ml in both phosphate buffer (pH 6.8) (Method A) and acetate buffer (pH 4.0) (Method B). The regression equations were found to be y = 0.101x+0.012 (r² = 0.999) and y = 0.064x+0.009 (r² = 0.999) in Method A and B respectively. The % RSD in precision studies was found to be 0.28-0.69 (Intra-day) and 0.31-0.73 (Inter-day) for Method A and 0.25-0.82 (Intra-day) and 0.26-0.57 (Inter-day) for Method B respectively. The % RSD in accuracy studies was also found to be 0.14-0.19 (Method A) and 0.18-0.23 (Method B) with percentage recovery 98.67-99.78 and 98.56-99.83 Method A and B respectively.

ACCESSION #

88017206

 

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