Phytochemical screening, cytotoxicity and anti-inflammatory activities of the Zimbabwean endemic plant Phyllanthus serpentinicola Radcl.-Sm. (Phyllanthaceae)

Zimudzi, C.; Gwenhure, L. F.; Kunonga, N.; Kativu, S.; Jere, J.
October 2012
Journal of Applied Pharmaceutical Science;Oct2012, Vol. 2 Issue 10, p50
Academic Journal
Stem methanolic extract of Phyllanthus serpentinicola was screened for phytochemicals, and tested for cytotoxicity and anti-inflammatory activities. Tests indicated presence of alkaloids, tannins, terpenoids, reducing sugars and flavonoids. Saponins, anthraquinones, and cardiac glycosides were absent. Cytotoxic effects of the plant were assessed through Brine shrimp lethality (BSL) bioassay. An LC50 value of 1.3 µg/ml was found, thus indicating that the stem extract was strongly cytotoxic. Anti-inflammatory activity was assessed by the egg albumen induced hind paw oedema test on Swiss albino mice. The extract significantly (p<0.05) reduced the oedema, thus indicating that P. serpentinicola has anti-inflammatory properties.


Related Articles

  • Phytochemical Analysis and Cytotoxicity Evaluation of Kelussia Odoratissima Mozaff. Momtazi-borojeniand, Amir Abbas; Sahebkar, Amirhosein // Medical journal of Mashhad University of Medical Sciences;2016 Special Issue, Vol. 59, p11 

    Introduction: Kelussia odoratissima Mozaff. (Apiaceae) is an edible, indigenous and ethnomedicinal plant, which only grows in Iran. In spite of antioxidant and anti-inflammatory properties, cytotoxic activity of this plant has not been previously investigated. The aim of this study was to...

  • Preliminary Phytochemical Screening, In-Vitro Antioxidant and Cytotoxic Activity of Five Different Extracts of Moringa Oleifera Leaf. Shahriar, Mohammad; Ismail Hossain, Md.; Nizam Md Bahar, Abu; Akhter, Sadika; Aminul Haque, Md.; Ahmed Bhuiyan, Mohiuddin // Journal of Applied Pharmaceutical Science;May2012, Vol. 2 Issue 5, p1 

    The purpose of this study was to judge the antioxidant activity and brine shrimp lethality bioassay followed by phytochemical screening of five different extracts of Moringa oleifera leaves. Preliminary Phytochemical screening of the crude extracts of Moringa oleifera leaf revealed the presence...

  • Phytochemical Screening, Cytotoxicity and Antibacterial Activities of Two Bangladeshi Medicinal Plants. Roy, Ajoy; Biswas, Subrata Kumar; Chowdhury, Anusua; Shill, Manik Chandra; Raihan, Sheikh Zahir; Muhit, Md. Abdul // Pakistan Journal of Biological Sciences;10/1/2011, Vol. 14 Issue 19, p905 

    The objectives of the present study were to investigate phytochemical screening and to assay cytotoxicity and antibacterial activities of ethanolic extracts of leaves of two medicinal plants, Aglaonema hookerianum Schott (Family: Araceae) and Lannea grandis Engl. (Family: Anacardiaceae)...

  • Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice. de Oliveira, Anderson Marques; Conserva, Lucia M.; de Souza Ferro, Jamylle N.; de Almeida Brito, Fabíola; Lemos, Rosângela P. Lyra; Barreto, Emiliano // International Journal of Molecular Sciences;Feb2012, Vol. 13 Issue 2, p1598 

    Sabicea species are used in the Amazon for treatment of fever and malaria, which suggests that its chemical constituents may have some effect on pain and inflammation. Phytochemical analysis of the hexane fraction obtained from the crude ethanol extract from Sabicea grisea var. grisea Cham. &...

  • Comparative Phytochemical Screening and In vitro Evaluation of Biological Activities between Aqueous and Ethanolic Extract of Momordica charantia L. Fruits. Das, Abhijit; Karmakar, Palash; Kibria, Golam; Debnath, Pankaj Chandra; Islam, Mohammad Safiqul; Sattar, Mohammad Mafruhi // British Journal of Pharmaceutical Research;3/16/2014, Vol. 4 Issue 6, p739 

    Aims: The study was conducted to compare the presence of different phytochemicals and biological activities like cytotoxicity, anthelmintic activity, antioxidant and free radical scavenging activities between aqueous and ethanolic extract of Momordica charantia L. Fruits. Methodology: The...

  • Preliminary sceening of Anti inflammatory and Antioxidant activity of Morinda umbellata. Dharsana, J. N.; Mathew, Molly // International Journal of Pharmacy & Life Sciences;Aug2014, Vol. 5 Issue 8, p3774 

    The presesent work was undertaken to evaluate the preliminary phytochemical, antioxidant and anti-inflammatory activity of Morinda umbellata. Bovine serum albumin denaturation inhibition assay was used for the evaluation of in-vitro anti-inflammatory activity and DPPH Free radical scavenging and...

  • PHYLLANTHUS AMARUS: AN AMPLE THERAPEUTIC POTENTIAL HERB. Kiran, Divya; Rohilla, Ankur; Rohilla, Seema; Khan, M. U. // International Journal of Research in Ayurveda & Pharmacy;Jul2011, Vol. 2 Issue 4, p1096 

    Herbal drugs have been one of the primarily used drugs since olden times for the treatment of a range of diseases. In addition, the medicinal plants have played a vital role in world health as the herbal plants still make an important contribution to health care. Phyllanthus amarus, a...

  • EVALUATION OF IN-VITRO ANTI-INFLAMMATORY, THROMBOLYTIC AND CYTOTOXIC PROPERTIES OF LABLAB NIGER LEAVES. Reyad-ul-Ferdous, Md.; Jisha, Hasnin Rahman; Azam, Md. Golam // International Journal of Pharmacy;2014, Vol. 4 Issue 2, p106 

    The present study was undertaken to investigate anti-inflammatory, thrombolytic and cytotoxic activities of methanol extracts of Lablab niger leaves and its different fractions. In-vitro anti-inflammatory activity of the L. niger leaves was evaluated by heat and hypotonic solution induced...

  • Synthesis and Evaluation of Conjugates of Non-steroidal Anti-inflammatory Drugs (NSAIDs) with Valproic Acid for Antiproliferative Properties and Apoptosis Induction. Mali, Sunil V.; Himaja, M.; Khanna, Amit; Periyasamy, Giridharan; Sikarwar, Mukesh // Journal of Pharmacy Research;Jul2011, Vol. 4 Issue 7, p2136 

    Valproic acid, an antiepileptic drug showed anticancer effects by inhibition of histone deacetylase (HDAC inhibitor). In this study, we have synthesized conjugates of valproic acid-NSAID such as aspirin, indomethacin, naproxen and sulindac containing Pro-Lys dipeptide linker. Their cytotoxicity...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics