TITLE

HPLC evaluation on 3-n-butylphthalide distribution

AUTHOR(S)
Qi Wang; Shuoyang Li; Peifeng Liu; Ming Shen; Tao Gong; Yourong Duan; Zhi-Rong, Zhang
PUB. DATE
October 2012
SOURCE
Journal of Applied Pharmaceutical Science;Oct2012, Vol. 2 Issue 10, p16
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A rapid, sensitive and specific reversed-phase high-performance liquid chromatographic method was developed for the determination of 3-n-butylphthalide, a drug currently being developed for treatment of stroke, in mice tissue. Ultraviolet detection were monitored at 228 nm for quantification of 3-nbutylphthalide. Ibuprofen was used as internal standard. The peak area ratio vs concentration in tissue was linear over the range of 25.625-1025.000 ng/mL and the limit of quantification was 25.625 ng/mL. The method was successfully applied to pharmacokinetic investigation in mice. The mean distribution half-life was 5.471 ± 4.736 min and elimination half-life was 58.459 ± 34.370 min. Finally, a preclinical biodistribution research of 3-n-butylphthalide in mice following intravenous administration had been studied. Brain targeting of 3-n-butylphthalide was strong and metabolism in the liver and blood was rapid.
ACCESSION #
88017161

 

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