Volejníková, J.; Mejstříková, E.; Dörge, P.; Černá, D.; Kanderová, V.; Budínský, V.; Stanulla, M.; Hrušák, O.; Starý, J.; Trka, J.; Kalina, T.; Froňková, E.
September 2012
Czecho-Slovak Pediatrics / Cesko-Slovenska Pediatrie;2012, Vol. 67 Issue 5, p321
Academic Journal
No abstract available.


Related Articles

  • Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia. Virely, C.; Moulin, S.; Cobaleda, C.; Lasgi, C.; Alberdi, A.; Soulier, J.; Sigaux, F.; Chan, S.; Kastner, P.; Ghysdael, J. // Leukemia (08876924);Jun2010, Vol. 24 Issue 6, p1200 

    A letter to the editor is presented in response to the article "Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia," in April 15, 2010 issue.

  • Function of Ikaros as a tumor suppressor in B cell acute lymphoblastic leukemia. Kastner, Philippe; Dupuis, Arnaud; Gaub, Marie-Pierre; Herbrecht, Raoul; Lutz, Patrick; Chan, Susan // American Journal of Blood Research;2013, Vol. 3 Issue 1, p1 

    The Ikaros transcription factor is crucial for many aspects of hematopoiesis. Loss of function mutations in IKZF1, the gene encoding Ikaros, have been implicated in adult and pediatric B cell acute lymphoblastic leukemia (B-ALL). These mutations result in haploinsufficiency of the Ikaros gene in...

  • Stage-specific control of early B cell development by the transcription factor Ikaros. Schwickert, Tanja A; Tagoh, Hiromi; Gültekin, Sinan; Dakic, Aleksandar; Axelsson, Elin; Minnich, Martina; Ebert, Anja; Werner, Barbara; Roth, Mareike; Cimmino, Luisa; Dickins, Ross A; Zuber, Johannes; Jaritz, Markus; Busslinger, Meinrad // Nature Immunology;Mar2014, Vol. 15 Issue 3, p283 

    The transcription factor Ikaros is an essential regulator of lymphopoiesis. Here we studied its B cell-specific function by conditional inactivation of the gene encoding Ikaros (Ikzf1) in pro-B cells. B cell development was arrested at an aberrant 'pro-B cell' stage characterized by increased...

  • An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities. Perotti, Elizabeth A.; Georgopoulos, Katia; Yoshida, Toshimi // PLoS ONE;7/2/2015, Vol. 10 Issue 7, p1 

    Ikaros DNA binding factor plays critical roles in lymphocyte development. Changes in Ikaros expression levels during lymphopoiesis are controlled by redundant but also unique regulatory elements of its locus that are critical for this developmental process. We have recently shown that Ikaros...

  • BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Mullighan, Charles G.; Miller, Christopher B.; Radtke, Ina; Phillips, Letha A.; Dalton, James; Jing Ma; White, Deborah; Hughes, Timothy P.; Le Beau, Michelle M.; Ching-Hon Pui; Relling, Mary V.; Shurtleff, Sheila A.; Downing, James R. // Nature;5/1/2008, Vol. 453 Issue 7191, p110 

    The Philadelphia chromosome, a chromosomal abnormality that encodes BCR–ABL1, is the defining lesion of chronic myelogenous leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). To define oncogenic lesions that cooperate with BCR–ABL1 to induce ALL, we performed a...

  • Lenalidomide induces degradation of IKZF1 and IKZF3. Krönke, Jan; Hurst, Slater N; Ebert, Benjamin L // OncoImmunology;Jul2014, Vol. 3 Issue 7, pN.PAG 

    Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to...

  • Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia. Lana, T; de Lorenzo, P; Bresolin, S; Bronzini, I; den Boer, M L; Cavé, H; Froňková, E; Stanulla, M; Zaliova, M; Harrison, C J; de Groot, H; Valsecchi, M G; Biondi, A; Basso, G; Cazzaniga, G; te Kronnie, G // Leukemia (08876924);Oct2015, Vol. 29 Issue 10, p2107 

    The article discusses a study which assessed the incidence of single-nucleotide mutations and in/del in the coding sequence of IKAROS (IKZF1), a transcription factor made up of the C-terminal and an N-terminal domain. The work showed the presence of IKZ1 mutations in at least 10% of pediatric...

  • IKZF1: a critical role in the pathogenesis of systemic lupus erythematosus? Hu, Su-juan; Wen, Lei-lei; Hu, Xin; Yin, Xian-yong; Cui, Yong; Yang, Sen; Zhang, Xue-jun // Modern Rheumatology (Springer Science & Business Media B.V.);Mar2013, Vol. 23 Issue 2, p205 

    Ikaros family zinc finger 1, encoded by IKZF1, are lymphoid-restricted zinc finger transcription factors that share common N-terminal Kruppel-like zinc finger DNA-binding domain. IKZF1 play multiple important roles on regulators of lymphocyte differentiation and hematological tumor suppressor....

  • An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes. Swafford, Austin D.-E.; Howson, Joanna M. M.; Davison, Lucy J.; Wallace, Chris; Smyth, Deborah J.; Schuilenburg, Helen; Maisuria-Armer, Meeta; Mistry, Trupti; Lenardo, Michael J.; Todd, John A. // Diabetes;Mar2011, Vol. 60 Issue 3, p1041 

    OBJECTIVE--IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association (GWA) studies have linked a region of the 3'-UTR of IKZF1 with C-ALL...

  • Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients. Meyer, Claus; zur Stadt, Udo; Escherich, Gabriele; Hofmann, Julia; Binato, Renata; da Conceição Barbosa, Thayana; Emerenciano, Mariana; Pombo-de-Oliveira, Maria S.; Horstmann, Martin; Marschalek, Rolf // American Journal of Blood Research;2013, Vol. 3 Issue 2, p165 

    Chromosomal translocations resulting in chimeric fusion genes are prototypic for pediatric leukemia patients. The most known fusions are ETV6-RUNX1 or BCR-ABL1 in B-cell progenitor (BCP)-ALL, and rearrangements of MLL in pediatric ALL and AML. Genome-wide sequencing projects have revealed...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics