TITLE

Thyroid Hormone Replacement Therapy Attenuates the Decline of Renal Function in Chronic Kidney Disease Patients with Subclinical Hypothyroidism

AUTHOR(S)
Shin, Dong Ho; Lee, Mi Jung; Lee, Hye Sun; Oh, Hyung Jung; Ko, Kwang Il; Kim, Chan Ho; Doh, Fa Mee; Koo, Hyang Mo; Kim, Hyoung Rae; Han, Jae Hyun; Park, Jung Tak; Han, Seung Hyeok; Yoo, Tae-Hyun; Kang, Shin-Wook
PUB. DATE
June 2013
SOURCE
Thyroid;Jun2013, Vol. 23 Issue 6, p654
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Subclinical hypothyroidism (SCH) is not a rare condition in females, the elderly, or patients with chronic kidney disease (CKD). Even though previous studies have demonstrated that thyroid hormone replacement therapy (THRT) improves cardiac function and dyslipidemia in patients with SCH, it remains unclear as to whether THRT can improve renal function in CKD patients with SCH. This study investigated the impact of THRT on changes in estimated glomerular filtration rates (eGFR) in this patient population. Methods: A total of 113 CKD patients with SCH who were treated with L-thyroxine and had eGFR available for at least 24 months before and after THRT were enrolled between January 2005 and December 2011. A linear mixed model was used to compare patients' clinical and biochemical parameters at various time points. The slope of the decline in eGFR over time, both before and after THRT, was also calculated and compared using a linear mixed model. Results: The mean age of the study participants was 63.2±12.7 years, and 36 patients (31.9%) were men. The mean follow-up duration before and after THRT was 28.6±4.5 and 30.6±6.4 months respectively. After 24 months of THRT, serum thyrotropin (TSH) levels were significantly reduced-8.86±0.49 versus 1.41±0.73 μIU/mL, p<0.001-but there were no significant changes in triiodothyronine and free thyroxine concentrations. Serum albumin, calcium, phosphate, cholesterol, and triglyceride levels were also comparable before and after THRT. The rates of decline in eGFR were significantly attenuated by THRT (−4.31±0.51 vs.−1.08±0.36 [mL/min]/[year·1.73 m2], p<0.001), even after adjustment for age, sex, diabetes, mean arterial pressure, and serum albumin, cholesterol, and triglyceride concentrations ( p<0.001). Conclusion: THRT attenuated the rate of decline in renal function in CKD patients with SCH, suggesting that THRT may delay reaching end-stage renal disease in these patients.
ACCESSION #
88006248

 

Related Articles

  • Identification and Functional Characterization of a Novel Mutation in the NKX2-1 Gene: Comparison with the Data in the Literature. Nettore, Immacolata Cristina; Mirra, Paola; Ferrara, Alfonso Massimiliano; Sibilio, Annarita; Pagliara, Valentina; Kay, Claudia Suemi Kamoi; Lorenzoni, Paulo Josè; Werneck, Lineu Cesar; Bruck, Isac; dos Santos, Lucia Helena Coutinho; Beguinot, Francesco; Salvatore, Domenico; Ungaro, Paola; Fenzi, Gianfranco; Scola, Rosana Herminia; Macchia, Paolo Emidio // Thyroid;Jun2013, Vol. 23 Issue 6, p675 

    Background: NKX2-1 mutations have been described in several patients with primary congenital hypothyroidism, respiratory distress, and benign hereditary chorea, which are classical manifestations of the brain-thyroid-lung syndrome (BTLS). Methods: The NKX2-1 gene was sequenced in the members of...

  • Sites of Metastases of Anaplastic Thyroid Carcinoma: Autopsy Findings in 45 Cases from a Single Institution. Besic, Nikola; Gazic, Barbara // Thyroid;Jun2013, Vol. 23 Issue 6, p709 

    Background: Despite surgical treatment, chemotherapy, and/or radiotherapy, the vast majority of patients with anaplastic thyroid carcinoma (ATC) have a dismal prognosis. Better knowledge of the frequency of metastases to different sites might help us to perform the appropriate diagnostic tests...

  • HYPOTHYROIDISM. Chiu, Alice C.; Yeung, Sai-Ching Jim // Cortlandt Forum;12/20/2000, Vol. 13 Issue 12, p111 

    Presents questions and answers on the diagnosis and symptomatology of the disease hypothyroidism. Classifications of the forms of hypothyroidism; Epidemiology of the disease; Screening for the disease; Common causes of hypothyroidism; Usual manifestations of hypothyroidism; Diagnostic...

  • Centennial of the Description of Hashimoto's Thyroiditis: Two Thought-Provoking Events. Duntas, Leonidas H.; Hiromatsu, Yuji; Amino, Nobuyuki // Thyroid;Jun2013, Vol. 23 Issue 6, p643 

    The article offers information on the Hashimoto's Thyroiditis which is also known as Autoimmune thyroiditis, is most common form of autoimmune thyroid disease (AITD). It mentions the clinical events that focuses on Hashimoto's Thyroiditis discussing several facts which includes investigating the...

  • Association Between Excessive Urinary Iodine Excretion and Failure of Radioactive Iodine Thyroid Ablation in Patients with Papillary Thyroid Cancer. Sohn, Seo Young; Choi, Joon Young; Jang, Hye Won; Kim, Hye Jeong; Jin, Sang Man; Kim, Se Won; Suh, Sunghwan; Hur, Kyu Yeon; Kim, Jae Hyeon; Chung, Jae Hoon; Kim, Sun Wook // Thyroid;Jun2013, Vol. 23 Issue 6, p741 

    Background: A low-iodine diet (LID) is usually recommended for a week or two before radioactive iodine (RAI) ablation therapy in papillary thyroid cancer (PTC) patients after total thyroidectomy. However, it is still controversial whether an LID affects ablation outcomes. We therefore evaluated...

  • Tiroid Patolojilerine Cerrahi Yaklasim ve Sonuçlari: 41 Olgunun Retrospektif Incelenmesi. Acar, Baran; Yıldız, Erdem; Kankılıç, Ekrem Said; Karaşen, Rıza Murat // Journal of Turgut Ozal Medical Center;2014, Vol. 21 Issue 1, p17 

    Objectives: In our country considered endemic, thyroid diseases are an important public health problem that affects the country's economy. Medical and surgical treatment of thyroid diseases has been carried out by many medical centers. In this study, we retrospectively evaluated patients with...

  • Ultrasonographic and Scintigraphic Findings of Thyroid Hemiagenesis in a Child: Report of a Rare Male Case. Ayaz, Ümit Yaşar; Ayaz, Sevin; Döğen, Mehmet Ercüment; Api, Arman // Case Reports in Radiology;2/15/2015, Vol. 2015, p1 

    Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of thyroid gland fails to develop. It is much rarer in males. There is a higher incidence of associated thyroid disorders in patients with thyroid hemiagenesis; therefore early and prompt diagnosis is important for children. We...

  • The Value of Repeat Thyroid Fine-Needle Aspiration Biopsy in Patients with a Previously Benign Result: How Often Does It Alter Management? Singh Ospina, Naykky; Sebo, Thomas J.; Morris, John C.; Castro, M. Regina // Thyroid;Oct2015, Vol. 25 Issue 10, p1121 

    Background: Thyroid nodules are prevalent and mostly benign, being present in up to 67% of the population when assessed by ultrasound. Due to the variable diagnostic performance of ultrasound-guided fine-needle aspiration biopsy (USFNA) of the thyroid and the possibility of a false-negative...

  • Increased Incidence of Thyroid Disease in Patients with Celiac Disease: A Systematic Review and Meta-Analysis. Sun, Xin; Lu, Li; Yang, Rong; Li, Yanbin; Shan, Ling; Wang, Yang // PLoS ONE;12/28/2016, Vol. 11 Issue 12, p1 

    The prevalence of thyroid disease is likely increased among individuals with celiac disease (CD). In addition, exposure to gluten-free treatment may be associated with a risk of thyroid disease, but this association remains controversial. A systematic review was performed to evaluate the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics