TITLE

Allergic rhinitis

AUTHOR(S)
Settipane, Russell A.; Schwindt, Christina
PUB. DATE
May 2013
SOURCE
American Journal of Rhinology & Allergy;May/Jun2013 Supplement, pS52
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Allergic rhinitis affects 60 million of the U.S. population, 1A billion of the global population, and its prevalence appears to be increasing. The duration and severity of allergic rhinitis symptoms place a substantial burden on patient's quality of life, sleep, ivork productivity, and activity. The health impact of allergic rhinitis is compounded by associated complications and comorbidities including asthma, otitis media, sinusitis, and nasal polyps. Allergic rhinitis symptoms result from a complex, allergen-driven mucosal inflammatory process, modulated by immunoglobulin E (IgE), and caused by interplay between resident and infiltrating inflammatory cells and a number of vasoactive and proinflammatory mediators, including cytokines. This allergic response may be characterized as three phases: IgE sensitization, allergen challenge, and elicitation of symptoms. A thorough allergic history is the best tool for the diagnosis of allergic rhinitis, the establishment of which is achieved by correlating the patient's history and physical exam with an assessment for the presence of specific IgE antibodies to relevant aeroallergens determined by skin testing or by in vitro assay. Management of allergic rhinitis includes modifying environmental exposures, implementing pharmacotherapy, and, in select cases, administering allergen-specific immunotherapy. Intranasal therapeutic options include antihistamines, anticholinergic agents, corticosteroids (aqueous or aerosol), mast cell stabilizers, saline, and brief courses of decongestants. Selection of pharmacotherapy is based on the severity and chronicity of symptoms with the most effective medications being intranasal corticosteroids and intranasal antihistamines, which can be used in combination (separately or infixed dose) for more difficult to control allergic rhinitis.
ACCESSION #
88004214

 

Related Articles

  • Determining the role of allergy in sinonasal disease. Settipane, Russell A.; Borish, Larry; Peters, Anju T. // American Journal of Rhinology & Allergy;May/Jun2013 Supplement, pS56 

    The contributing role of specific IgE sensitization in the pathophysiology of sinonasal diseases including rhinitis, chronic rhinosinusitis (CRS), and nasal polyps is explored. Although it is estimated that sensitization to environmental allergens is present in 75% of patients with rhinitis, the...

  • Bilateral Nasal Polyps Originating From Olfactory Cleft. Kayabasoglu, Gurkan; Cagdas Kazıkdas, Kadir // European Journal of General Medicine;2015, Vol. 12 Issue 3, p271 

    Nasal polyps generally have similar symptom, they generally originate from ethmoid infundibulum, mucosal contact areas of the uncinate process and middle turbinate. However nasal polyps rarely arise from different and unexpected locations in the nasal cavity such as septum, cribriform plate and...

  • Quick injections blow hay fever away.  // New Scientist;1/4/2014, Vol. 221 Issue 2950, p15 

    The article discusses the development of a shot by scientists at the biotechnology firm Biomay that combines part of a pollen molecule with a hepatitis B protein for preventing hay fever, which is caused by an overreaction to pollen by the immune system's immunoglobulin E (IgE) antibodies.

  • Mommy Musings: A Lot to Swallow. Legum, Laurie // Baltimore Jewish Times;11/16/2012, Vol. 329 Issue 3, p5 

    The article offers the author's insights on how she managed to treat the symptoms of allergic rhinitis of her baby.

  • JUST STICK IT.  // Ebony;May2015, Vol. 70 Issue 7, p70 

    The article discusses a study published in the "American Journal of Chinese Medicine" that reveals the effectivity of acupuncture in reducing the symptoms of hay fever, minus any side effects.

  • THE ANTIINFLAMMATORY EFFECT OF H1 ANTIHISTAMINES IN ALLERGIC RHINITIS. Bocşan, Corina; Cristea, V. // Therapeutics, Pharmacology & Clinical Toxicology;2011, Vol. 15 Issue 1, p13 

    Allergic rhinitis is an immune inflammatory process, IgE mediated, which affects nasal mucosa. The immune allergic response presents 3 phases and involves many cells and mediators. Interleukins are involved both in producing and maintaining this process. Il-1, Il-6 and TNF-a increase allergic...

  • Nonallergic rhinitis. Settipane, Russell A.; Kaliner, Michael A. // American Journal of Rhinology & Allergy;May/Jun2013 Supplement, pS48 

    Rhinitis is characterized by one or more of the following nasal symptoms: congestion, rhinorrhea (anterior and posterior), sneezing, and itching. It is classified as allergic or nonallergic, the latter being a diverse syndrome that is characterized by symptoms of rhinitis that are not the result...

  • budesonide.  // Royal Society of Medicine: Medicines;2002, p123 

    The article presents information on budesonide, a corticosteroid with anti-inflammatory and anti-allergic properties, which is used to treat and prevent attacks of asthma, allergic and vasomotor rhinitis and nasal polyps. Administration is by inhalation or a nasal spray, or topically as a cream...

  • Effects of Antihistamines on Leukotriene and Cytokine Release from Dispersed Nasal Polyp Cells. Kusters, Sabine; Schuligoi, Rufina; Huttenbrink, Karl-Bernd; Rudert, Jutta; Wachs, Angela; Szelenyi, Istvan; Peskar, Bernhard A. // Drug Research / Arzneimittel-Forschung;Feb2002, Vol. 52 Issue 2, p97 

    In this study the effects of antihistamines on the release of eicosanoids and the pro-inflammatory cytokine tumor necro-sis factor alpha (TNF.... ) were compared. Enzymatically dispersed cells from hu-man nasal polyps served as an in vitro model of chronic respiratory mucosal...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics