TITLE

Quantitative determination of Asenapine in both bulk and formulations using neutralization titrations

AUTHOR(S)
Aarelly, Kiran; Thimmaraju, Manish Kumar; Nerella, Raghunandan
PUB. DATE
August 2012
SOURCE
Journal of Applied Pharmaceutical Science;Aug2012, Vol. 2 Issue 8, p141
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Asenapine is used in the treatment of schizophrenia disease. Asenapine mainly control the psychotic symptoms' mainly antagonist to various receptors like, serotonin (5-HT1A, 5- HT1B,5-HT2A,5-HT2B,),histamine, and dopamine(D1,D2,D3,D4) receptors. It is also lower affinity towards muscaranic and acetylcholine receptors. In the present study, simple titrimetric method was developed. Respective quantities of Asenapine were taken in aqueous methanol titrated against 0.1N sodium hydroxide acid and 0.1N potassium hydroxide acid using phenolphthalein as an indicators for neutralization titration. This method were found to be sensitive and inexpensive, do not require any sample processing steps and can be utilized for estimation of asenapine in bulk and formulations.
ACCESSION #
88001345

 

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