TITLE

Anti-inflammatory Effect of Apigenin-7-neohesperidoside (Rhoifolin) in Carrageenin-Induced Rat Oedema Model

AUTHOR(S)
Eldahshan, Omayma A.; Azab, Samar S.
PUB. DATE
August 2012
SOURCE
Journal of Applied Pharmaceutical Science;Aug2012, Vol. 2 Issue 8, p74
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Flavonoids are normal constituents of the human diet and are known for a variety of biological activities. They have been reported to bring benefits in lowering inflammation and oxidative stress. The present investigation was performed first, to evaluate the anti-inflammatory activity of rhoifolin and second, to search for the possible contributing mechanisms for this hypothesized effect. Rhoifolin caused a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema. Following 4 hr of treatment, rhoifolin at doses 2.5, 25 & 250 mg/kg caused a significant inhibition of rat paw edema volume by 14, 25 & 45 % respectively in comparison to the control group (74%). In addition to significantly abrogating prostaglandin E2 level, increasing doses of rhoifolin significantly diminished the TNF-a release in the inflammatory exudates. In the same animal model, rhoifolin increased the total antioxidant capacity in a reverse dose order, with the highest capacity obtained with the lowest dose tested. This study demonstrates for the first time the effectiveness.
ACCESSION #
88001332

 

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