Anti-inflammatory Effect of Apigenin-7-neohesperidoside (Rhoifolin) in Carrageenin-Induced Rat Oedema Model

Eldahshan, Omayma A.; Azab, Samar S.
August 2012
Journal of Applied Pharmaceutical Science;Aug2012, Vol. 2 Issue 8, p74
Academic Journal
Flavonoids are normal constituents of the human diet and are known for a variety of biological activities. They have been reported to bring benefits in lowering inflammation and oxidative stress. The present investigation was performed first, to evaluate the anti-inflammatory activity of rhoifolin and second, to search for the possible contributing mechanisms for this hypothesized effect. Rhoifolin caused a time and reverse dose dependent reduction of carrageenin-induced rat paw oedema. Following 4 hr of treatment, rhoifolin at doses 2.5, 25 & 250 mg/kg caused a significant inhibition of rat paw edema volume by 14, 25 & 45 % respectively in comparison to the control group (74%). In addition to significantly abrogating prostaglandin E2 level, increasing doses of rhoifolin significantly diminished the TNF-a release in the inflammatory exudates. In the same animal model, rhoifolin increased the total antioxidant capacity in a reverse dose order, with the highest capacity obtained with the lowest dose tested. This study demonstrates for the first time the effectiveness.


Related Articles

  • Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata. Hai-Liang Xin; Xiao-Feng Zhai; Xu Zheng; Lei Zhang; Yu-Liang Wang; Zhuo Wang // Molecules;Aug2012, Vol. 17 Issue 8, p8842 

    The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic...

  • The anti-inflammatory effects of venlafaxine in the rat model of carrageenan-induced paw edema. Hajhashemi, Valiollah; Minaiyan, Mohsen; Banafshe, Hamid Reza; Mesdaghinia, Azam; Abed, Alireza // Iranian Journal of Basic Medical Sciences;Jul2015, Vol. 18 Issue 7, p654 

    Objective(s): Recently anti-inflammatory effects of antidepressants have been demonstrated. Venlafaxine belongs to newer antidepressants with serotonin norepinephrine reuptake inhibition property. The pain alleviating properties of venlafaxine in different pain models such as neurogenic pain,...

  • Investigation into the Anti-inflammatory and Antigranuloma Activity of Colchicum luteum Baker in Experimental Models. Nair, Vinod; Kumar, Rohit; Singh, Surender; Gupta, Y. // Inflammation;Jun2012, Vol. 35 Issue 3, p881 

    The present study evaluates the anti-inflammatory and antigranuloma activity of CLHE in experimental models, viz. carrageenan-induced paw edema, subcutaneous cotton pellet implantation-induced granuloma formation, and complete Freund's adjuvant-induced stimulation of peritoneal macrophages in...

  • The anti-inflammatory effect of diclofenac is considerably augmented by topical capsaicinoids-containing patch in carrageenan-induced paw oedema of rat. Ercan, Nilufer; Uludag, Mecit; Agis, Erol; Demirel-Yilmaz, Emine // Inflammopharmacology;Dec2013, Vol. 21 Issue 6, p413 

    Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most used drugs in musculoskeletal disorders, but their systemic adverse effects limit their therapeutic benefit in local inflammation. On the other hand, topical preparations of capsaicinoids are widely used for musculoskeletal disorders as...

  • Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model. Sakat, Sachin; Mani, Kamaraj; Demidchenko, Yulia; Gorbunov, Evgeniy; Tarasov, Sergey; Mathur, Archna; Epstein, Oleg // Inflammation;Feb2014, Vol. 37 Issue 1, p1 

    The study was aimed to investigate the effect of technologically treated diclofenac (release-active dilutions of diclofenac (RAD of diclofenac)) on anti-inflammatory activity of diclofenac in carrageenan-induced rat paw edema model. Ninety male Wistar albino rats (6-8 weeks) divided into nine...

  • Synthesis and In Vivo anti-inflammatory activity of some 4-aryl-5-cyno-6-methyls-3- substituted pyrimidines and 4-aryl-5-cyno-6-ethyl-3-substituted pyrimidines. More, Dhananjay H.; Sapkal, Bharatkumar M. // Journal of Pharmacy Research;Sep2011, Vol. 4 Issue 9, p3200 

    One pot synthesis of Ureidopropenenitriles was carried out by condensation of substituted benzoylacetonitrile, triethyl orthoacetate/triethyl orthopropanoate and urea/substituted urea in presence of Ammonium acetate. Ureidopropenenitriles were cyclized to 4-aryl-5-cyno-6-methyl-3- substituted...

  • Topical anti-inflammatory activity of herbal gel formulation. Kulkarni, Parag A.; Kewatkar, Shailesh; Lande, Meghana D.; Phanse, Mohini. A.; Chaudhari, Pravin D. // Der Pharma Chemica;2010, Vol. 2 Issue 3, p338 

    The management and treatment of pain is probably one of the most common and yet the most difficult aspects of medicinal practice. This study evaluated a new herbal preparation containing extract from leaves of Vitex negundo (VN) for its topical anti-inflammatory activity against carrageenan...

  • Pharmacological evaluation of Ammania baccifera Linn. Gopalakrishnan, S.; Kamalutheen, M.; Ismail, T. Syed; Vadivel, E. // Journal of Pharmacy Research;Jul2010, Vol. 3 Issue 7, p1547 

    This study was intended to evaluate the anti-inflammatory and anti-arthritic activities of different extracts Ammania baccifera Linn. In this study both acute and chronic inflammation models were used to evaluate the anti-inflammatory and anti-arthritic activities of the Ammania baccifera. In...

  • Anti-inflammatory activity of fruits of Sapindus trifoliatus Linn. Fernandes, Jennifer; Fernandes, Ronald // Journal of Pharmacy Research;Nov2011, Vol. 4 Issue 11, p3933 

    Effects of ethanolic extract of the fruits of S.trifoliatus was studied in albino rats to assess its anti- inflammatory property against the paw oedema and cotton pellet granuloma.The study revealed that the fruits extract at the dose levels of 100, 200 and 400mg/kg body weight significantly...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics