TITLE

Protective effect of regular aerobic training on inflammatory and toxicity markers of lung tissue in L-NAME-induced hypertension

AUTHOR(S)
Heidarzadeh, Roghoye; Roshan, Valiollah Dabidi; Ashrafi, Javad
PUB. DATE
August 2012
SOURCE
Journal of Applied Pharmaceutical Science;Aug2012, Vol. 2 Issue 8, p68
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hypertension is a multi-factorial, life-threatening disease. The present study was designed to investigate protective effect of aerobic regular training on inflammatory and toxicity markers in lung tissue of male wistar rats exposed to chronic nitro-L-arginine-methyl ester(L-NAME)-induced hypertension. Thirty two adult male Wistar rats are randomly classified into 4 groups; aerobic training, L-NAME, saline and control groups. Hypertension was induced by administration of L-NAME (10 mg/kg) for 8 weeks and 6 sessions a week. Aerobic training was performed between 25 to 64 minutes and the speed 15 to 22 m/min for 8 weeks and 5 sessions a week. Chronically administration of L-NAME cause a significant increase in angiotensin converting enzyme (ACE), interleukin 6 (IL-6) levels, and a significant decrease in superoxide dismutase (SOD) and nitric oxide (NO) levels, as compared to saline and control groups. In contrast, aerobic training for 8 weeks caused a significant increase in SOD, NO and a significant decrease in IL-6 and protein carbonyl (PC), as compared to LNAME and saline groups. Our study suggests aerobic regular exercise provided significant protection against L-NAME-induced toxicity in lung tissue by up-regulation of antioxidant systems and down-regulation of the inflammatory and vasoconstrictor factors in hypertensive rats. These results suggest that aerobic regular exercise may be considered as a potentially useful strategy to limit toxicity in lung tissue.
ACCESSION #
88001331

 

Related Articles

  • Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study.  // Nutrition & Metabolism;2011, Vol. 8 Issue 1, p71 

    The article focuses on the study conducted to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone biomarkers and bone mineral density (BMD) in post-menopausal women. The study reveals long-term aerobic exercise training plus N-3...

  • Effects of Aerobic Training on Inflammation marker and CVD in women. ALHINDAWI, MOHAMMAD // Journal of Physical Education & Sport;2013, Vol. 13 Issue 3, p452 

    The purpose of this study was to investigate the effects of 14 weeks of Aerobic training on C-reactive protein (CRP) in postmenopausal women. And if the intensity of 60-75% of the average maximum heart rate is expected recommendation intensity that will leads to lower CRP values. Twenty...

  • The Liver Toxicity Biomarker Study Phase I: Markers for the Effects of Tolcapone or Entacapone. McBurney, Robert N.; Hines, Wade M.; VonTungeln, Linda S.; Schnackenberg, Laura K.; Beger, Richard D.; Moland, Carrie L.; Han, Tao; Fuscoe, James C.; Chang, Ching-Wei; Chen, James J.; Su, Zhenqiang; Fan, Xiao-hui; Tong, Weida; Booth, Shelagh A.; Balasubramanian, Raji; Courchesne, Paul L.; Campbell, Jennifer M.; Graber, Armin; Guo, Yu; Juhasz, Peter // Toxicologic Pathology;Aug2012, Vol. 40 Issue 6, p951 

    The Liver Toxicity Biomarker Study is a systems toxicology approach to discover biomarkers that are indicative of a drug’s potential to cause human idiosyncratic drug-induced liver injury. In phase I, the molecular effects in rat liver and blood plasma induced by tolcapone (a...

  • High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo. Antoine, Daniel J.; Williams, Dominic P.; Kipar, Anja; Jenkins, Rosalind E.; Regan, Sophie L.; Sathish, Jean G.; Kitteringham, Neil R.; Park, B. Kevin // Toxicological Sciences;Dec2009, Vol. 112 Issue 2, p521 

    Drug-induced hepatotoxicity represents a major clinical problem and an impediment to new medicine development. Serum biomarkers hold the potential to provide information about pathways leading to cellular responses within inaccessible tissues, which can inform the medicinal chemist and the...

  • Influence of 9-Weeks Aerobic Exercise and Multivitamin Supplement on Inflammation Biomarkers as Cardiovascular Risk Factor in Non-athletic Obese Women. Tartibian, Bakhtiar; Godrat-Garebagh, Zahra; Gaeini, Abbasali; Tolouei-Azar, Javad // Zahedan Journal of Research in Medical Sciences;Mar2013, Vol. 15 Issue 3, p30 

    Background: The aim of this study was to determine the effect of 9 weeks aerobic exercise and multivitamin supplement on plasma level of HCY, CRP and TNF-a in nonathletic obese women. Materials and Methods: Total 30 sedentary and healthy obese women aged 25-50 year and BMI =30 Kg/m² P...

  • Biology -- Disease.  // Current Medical Literature: Pulmonary Hypertension;2013, Vol. 4 Issue 1, p11 

    The article presents expert commentaries on several research papers related to pulmonary arterial hypertension. They include research which investigated the pathogenic role of serotonin (5-HT) in pulmonary arterial hypertension (PAH) in mice, published in a 2012 issue of the "American Journal of...

  • Project 1: "Validation of Biomarkers in Pulmonary Arterial Hypertension". Lan Zhao // PVRI Review;Jan-Dec2012, Vol. 4 Issue 1/2, p50 

    The article offers information on a study which examines the validation of positron emission tomography (PET), a non-invasive biomarker used to measure the right ventricle uptake levels of patient with pulmonary hypertension (PH), conducted by the Pulmonary Vascular Research Institute (PRVI).

  • Update of Faecal Markers of Inflammation in Children with Cystic Fibrosis. Lee, Jung M.; Leach, Steven T.; Katz, Tamarah; Day, Andrew S.; Jaffe, Adam; Ooi, Chee Y. // Mediators of Inflammation;2012, Vol. 2012, p1 

    There is evidence of intestinal inflammation in patients with CF. Intestinal inflammation may negatively impact the nutritional status of patient with CF, which adversely affects pulmonary function and survival. This paper provides an up-to-date review of intestinal inflammation in CF and an...

  • Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 Is Linked to TNF-α Pharmacology. Erickson, Rebecca I.; Tarrant, Jacqueline; Cain, Gary; Lewin-Koh, Sock-Cheng; Dybdal, Noel; Wong, Harvey; Blackwood, Elizabeth; West, Kristina; Steigerwalt, Ronald; Mamounas, Michael; Flygare, John A.; Amemiya, Kenjie; Dambach, Donna; Fairbrother, Wayne J.; Diaz, Dolores // Toxicological Sciences;Jan2013, Vol. 131 Issue 1, p247 

    Inhibitor-of-apoptosis (IAP) proteins suppress apoptosis and are overexpressed in a variety of cancers. Small-molecule IAP antagonists are currently being tested in clinical trials as novel cancer therapeutics. GDC-0152 is a small-molecule drug that triggers tumor cell apoptosis by selectively...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics