Management of Changes in Liver Chemistry in Male Rats Acutely Exposed to Crude Petroleum Oil

Ujowundu, C. O.; Kalu, F. N.; Nwaogu, L. A.; Ezeji, E. U.; Igwe, K. O.
June 2012
Journal of Applied Pharmaceutical Science;Jun2012, Vol. 2 Issue 6, p116
Academic Journal
This Study investigated the protective effect of Gongronema latifolium supplemented diet against acute hepatotoxicity induced by crude petroleum oil on male rats. Oral exposure of rats to crude petroleum significantly decreased (P<0.05) the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD). Significant decrease in concentrations of glutathione and increase in malondialdehyde (MDA) was observed also, but catalase activity decreased nonsignificantly. Activities of these oxidative stress enzymes and concentrations of glutathione and MDA in rats exposed to crude petroleum and fed simultaneously with 20% G. latifolium supplemented diet were close to those obtained in control rats. Fluctuations in liver function parameters and serum lipid profile were observed. These results indicate that consumption of G. latifolium supplemented diet has protective effect against crude oil induced liver tissue damage.


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