TITLE

Formulation and Evaluation of Sustained Release Matrix Tablets of Glimepiride Based on Combination of Hydrophilic and Hydrophobic Polymers

AUTHOR(S)
Hadi, Abdul; Babu, V. Lokeswara; Pal, Narottam
PUB. DATE
June 2012
SOURCE
Journal of Applied Pharmaceutical Science;Jun2012, Vol. 2 Issue 6, p101
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The objective of this study was to develop sustained release tablets of glimepiride by wet granulation method based on combination of hydrophilic (HPMC15cps, HPC) and hydrophobic (Ethyl cellulose) polymers. The drug excipient mixtures were subjected to preformulation studies. The tablets were subjected to physicochemical studies, in- vitro drug release, kinetic studies and stability studies. FTIR and DSC studies shown there was no interaction between drug and polymers. The physicochemical properties of tablets were found within the limits. Glimepiride is a first third generation sulphonyl urea agent for the treatment type II diabetes mellitus. The drug release from the optimized formulation was extended for a period of 12 hrs. The kinetic treatment showed that the release of drug follows first order models. The optimized formulations were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern. Results of the present study indicated the suitability of the above mentioned polymers in the preparation of sustained release formulation of glimepiride.
ACCESSION #
88001293

 

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