TITLE

Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia

AUTHOR(S)
Kim, Yeon A.; Tae Dong Kweon; Myounghwa Kim; Hye In Lee; You Jin Lee; Lee, Ki-Young
PUB. DATE
March 2013
SOURCE
Korean Journal of Anesthesiology;Mar2013, Vol. 64 Issue 3, p229
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Shivering is a frequent event during spinal anesthesia and meperidine is a well-known effective drug for prevention and treatment of shivering. Nefopam is a non-opiate analgesic and also known to have an anti-shivering effect. We compared nefopam with meperidine for efficacy of prevention of shivering during spinal anesthesia. Methods: Sixty five patients, American Society of Anesthesiologists physical status I or II, aged 20-65 years, scheduled for elective orthopedic surgery under spinal anesthesia were investigated. Patients were randomly divided into two groups, meperidine (Group M, n = 33) and nefopam (Group N, n = 32) groups. Group M and N received meperidine 0.4 mg/kg or nefopam 0.15 mg/kg, respectively, in 100 ml of isotonic saline intravenously. All drugs were infused for 15 minutes by a blinded investigator before spinal anesthesia. Blood pressures, heart rates, body temperatures and side effects were checked before and at 15, 30, and 60 minutes after spinal anesthesia. Results: The incidences and scores of shivering were similar between the two groups. The mean arterial pressures in Group N were maintained higher than in Group M at 15, 30, and 60 minutes after spinal anesthesia. The injection pain was checked in Group N only and its incidence was 15.6%. Conclusions: We conclude that nefopam can be a good substitute for meperidine for prevention of shivering during spinal anesthesia with more stable hemodynamics, if injection pain is effectively controlled.
ACCESSION #
88001240

 

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