A retrospective cross-sectional study: fresh cycle endometrial thickness is a sensitive predictor of inadequate endometrial thickness in frozen embryo transfer cycles

Jimenez, Patricia T.; Schon, Samantha B.; Odem, Randall R.; Ratts, Valerie S.; Jungheim, Emily S.
June 2013
Reproductive Biology & Endocrinology;2013, Vol. 11 Issue 1, p1
Academic Journal
Background: The purpose of this study is to assess predictors of inadequate endometrial cavity thickness (ECT), defined as < 8 mm, in frozen embryo transfer (FET) cycles. Methods: This is a retrospective cross-sectional study at an academic fertility center including 274 women who underwent their first endometrial preparation with estradiol for autologous FET in our center from 2001-2009. Multivariable logistic regression was performed to determine predictors of inadequate endometrial development in FET cycles. Results: Neither age nor duration of estrogen supplementation were associated with FET endometrial thickness. Lower body mass index, nulliparity, previous operative hysteroscopy and thinner fresh cycle endometrial lining were associated with inadequate endometrial thickness in FET cycles. A maximum thickness of 11.5 mm in a fresh cycle was 80% sensitive and 70% specific for inadequate frozen cycle thickness. Conclusions: Previous fresh cycle endometrial cavity thickness is associated with subsequent FET cycle endometrial cavity thickness. Women with a fresh cycle thickness of 11.5 mm or less may require additional intervention to achieve adequate endometrial thickness in preparation for a frozen cycle.


Related Articles

  • Frozen-thawed Embryos Have Better Outcomes than Fresh Embryos. Anja Pinborg // Fertility Weekly;3/18/2013, p10 

    The article focuses on a study conducted in Denmark which determines the benefits and drawbacks of frozen embryo replacement (FER) in comparison to fresh embryo transfer. It discovers similar malformation rates in infants from frozen and fresh in vitro fertilization (IVF) with intracytoplasmic...

  • Emergency IVF for embryo freezing to preserve female fertility: a French multicentre cohort study. Courbiere, B.; Decanter, C.; Bringer-Deutsch, S.; Rives, N.; Mirallié, S.; Pech, J. C.; De Ziegler, D.; Carré-Pigeon, F.; May-Panloup, P.; Sifer, C.; Amice, V.; Schweitzer, T.; Porcu-Buisson, G.; Poirot, C. // Human Reproduction;Sep2013, Vol. 28 Issue 9, p2381 

    STUDY QUESTION What are the outcomes of French emergency IVF procedures involving embryo freezing for fertility preservation before gonadotoxic treatment? SUMMARY ANSWER Pregnancy rates after emergency IVF, cryopreservation of embryos, storage, thawing and embryo transfer (embryo transfer), in...

  • Factors predicting the cumulative outcome of IVF/ICSI treatment: a multivariable analysis of 2450 patients. Cai, Q.F.; Wan, F.; Huang, R.; Zhang, H.W. // Human Reproduction;Sep2011, Vol. 26 Issue 9, p2532 

    BACKGROUND Knowing predictors of pregnancy in IVF is helpful for clinicians to individualize the treatment plans and improve patient counseling and for patients to decide whether to undergo infertility treatment. The aim of the study was to identify independent predictors of the chance of...

  • Outcomes of natural cycles versus programmed cycles for 1677 frozen--thawed embryo transfers. Givens, Carolyn R.; Markun, Leslie C.; Ryan, Isabelle P.; Chenette, Philip E.; Herbert, Carl M.; Schriock, Eldon D. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Sep2009, Vol. 19 Issue 3, p380 

    The study compares outcomes for patients with frozen embryos who had frozen-thawed embryo transfer (FET) timed to their natural ovulation cycle versus cycles in which endometrial timing was programmed with oestrogen and progesterone. A total of 1205 patients undergoing 1677 FET cycles between 1...

  • Effect of High Progesterone Levels at the End of the Follicular Phase.  // Fertility Weekly;10/10/2011, p9 

    The article presents a study conducted by E. Labarta and associates in Spain which investigates the effects of high progesterone levels in controlled ovarian stimulation's (COS) follicular phase. The study discovers that the gene expression profile of endometrium is changed by these high...

  • Predictive factors for live birth in cryopreservation single embryo transfer cycles. Olivius, C.; Lundin, K.; Bergh, C. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2008, Vol. 17 Issue 5, p676 

    IVF cryopreservation cycles are known to be less successful than fresh cycles. The objective of this study was to investigate what variables, maternal and embryonic, that independently predict the live birth rate in cryopreservation single embryo transfers (SET). A retrospective analysis was...

  • The Added Value of Embryo Cryopreservation to Cumulative Ongoing Pregnancy Rates Per IVF Treatment: Is Cryopreservation Worth the Effort? de Jong, D.; Eijkemans, M.J.C.; Beckers, N.G.M.; Pruijsten, R.V.; Fauser, B.C.J.M.; Macklon, N.S. // Journal of Assisted Reproduction & Genetics;Dec2002, Vol. 19 Issue 12, p561 

    Examines the efficacy of embryo cryopreservation to the cumulative pregnancy rate in vitro fertilization. Percentage of cumulative pregnancy outcome per cryopreserved embryo transfer; Increase in pregnancy outcome; Limitations on the supplementary benefit of cryopreservation.

  • Incidence of Large Baby Syndrome. Pinborg, A. // Fertility Weekly;8/18/2014, p5 

    The article discusses a study conducted in Denmark suggesting higher risk of large baby syndrome in singletons born after frozen embryo transfer (FET). The study involves two frozen embryo populations on singletons born after FET including born between 1997 and 2006 and sibling pairs between...

  • Effect of vitrification versus slow freezing of human day 3 embryos on β-hCG levels. Xue, Yamei; Tong, Xiaomei; Jiang, Lingying; Zhu, Haiyan; Yang, Lingyun; Zhang, Songying // Journal of Assisted Reproduction & Genetics;Aug2014, Vol. 31 Issue 8, p1037 

    Purpose: The study was designed to investigate the effect of vitrification and slow freezing for the cryopreservation of human day 3 embryos on serum β-hCG levels in pregnancies established after frozen embryo transfer (FET). Methods: Of the 1384 FET cycles initiated, 1131 embryo transfers...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics