Mandlik, Satish K.; Adhikari, Saugat; Ranpise, Nisharani S.
January 2013
Pharmacie Globale;Jan2013, Vol. 4 Issue 1, p1
Academic Journal
Chitosan biodegradable nanoparticles (CBN) of zolmitriptan (ZMT) were prepared by the ionic gelation method using polyanion sodium tripolyphosphate (STPP) as a cross-linking agent and their in-vitro characteristics were studied. The different formulations with varying ratio of chitosan: drug was prepared and freeze dried. Solid- state analysis was undertaken using thermal methods (DSC/MDSC), and fourier transform infra-red spectroscopy (FT-IR). The particle size and morphology was determined by laser scattering technique and transmission electron microscopy, respectively. FTIR and DSC showed no significant interactions between chitosan and drug, STPP and drug. Particle size distribution analysis confirmed the size ranges, with a narrow size distribution. TEM indicated smooth and spherical Nanoparticles. The drug was chemically stable, with 75.4% to 80.6% entrapment efficiency and 26.31% to 36.92% drug loading in the nanoparticles. The in-vitro drug release studies showed that after the initial burst, all the different drug-loaded CBN provided a continuous and slow release of the drug. The CBN system demonstrates capability to ZMT, antimigraine drug to potentially provide an effective treatment option in migraine therapy.


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