Tarakaramarao, Ch; Vijayalekshmi, N. G.; Akhila, S.
January 2013
Pharmacie Globale;Jan2013, Vol. 4 Issue 1, p1
Academic Journal
Conventionally, vaginal delivery was restricted to locally acting drugs such as antibacterial, antifungal, anti-viral, spermicidal, labour-inducing agents, prostaglandins and steroids. The major advantages of this route include accessibility, good blood supply, the ability to bypass first-pass liver metabolism, and permeability to large molecular weight drugs, such as peptides and proteins. Suppositories, creams, gels, tablets and vaginal rings are commonly used vaginal drug delivery systems. The purpose of this communication is to provide the reader with a summary of advances made in the field of vaginal drug delivery. This report, therefore, summarizes various vaginal drug delivery systems with an introduction to vaginal physiology and factors affecting drug absorption from the vaginal route.


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