TITLE

Synthesis of novel thienopyrimidines and evaluation for their anti-inflammatory activity

AUTHOR(S)
Goudar, Venkanagouda; Rashmi, P.; Shantharam, U.; Hazra, Kuntal; Nargund, Laxmivenkatesh G.
PUB. DATE
June 2012
SOURCE
Journal of Chemical & Pharmaceutical Research;2012, Vol. 4 Issue 6, p3100
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thienopyrimidines forms a significant class of drugs which exhibit an array of biological activities ranging from anti-inflammatory, antibacterial, antifungal, analgesic, antiviral to anticancer activity. In continuation of our research program on thienopyrimidines, the present study focused on synthesizing the thienopyrimidines derivatives possessing different heterocyclic rings to obtain highly potent anti-inflammatory agents. Thienopyrimidines have been synthesized by the cyclisation of thiophene with formamide to obtain thieno [2, 3-d] pyrimidine. The synthesized compounds were screened for their anti-inflammatory activity using bovine serum albumin denaturation (in vitro) assay model, by using ibuprofen as a standard. The present study has given deep insight as the thienopyrimidines bearing pyrazole, oxadiazole and thiadiazole rings shown significant anti-inflammatory activity. The compound (8a) containing thiadiazole was found to be most potent.
ACCESSION #
87976843

 

Related Articles

  • SOURCE, PRODUCTION AND BIOLOGICAL ACTIVITIES OF PICEATANNOL: A REVIEW. Kukreja, A.; Mishra, A.; Tiwari, A. // International Journal of Pharmaceutical Sciences & Research;Oct2013, Vol. 4 Issue 10, p3738 

    Phenolic compounds are group of molecules which contain different families of secondary metabolites. Phenolic compounds, secondary metabolites, are abundantly found in plants and are mostly categorized into two major groups: non-soluble compounds and soluble compounds. Stilbenes which come under...

  • Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4-phenoxyphenol derivatives. PARSAI, SHIREEN; KECK, RICK; SKRZYPCZAK-JANKUN, EWA; JANKUN, JERZY // Oncology Letters;2014, Vol. 7 Issue 1, p17 

    Curcumin, a non-nutritive yellow pigment derived from the rhizome of Curcuma longa (turmeric), is considered to be an established nutraceutical with anticancer activity. Turmeric contains three principal components, curcumin, demethoxycurcumin and bisdemethoxycurcumin, of which curcumin is most...

  • Methotrexate update 2014: 70 years in autoimmunity and cancer treatment. Řiháček, M.; Řiháček, I.; Zdražilová-Dubská, L.; Pilátová, K. // Czecho-Slovak Pediatrics / Cesko-Slovenska Pediatrie;2014, Vol. 69 Issue 3, p161 

    Immunosupressive and antineoplastic activity brought methotrexate to its clinical use many years ago. Although modern antitumour and antiinflammatory drugs and new antifolates have challenged methotrexate, its use in rheumatoid arthritis and in some types of pediatric and adult malignancies...

  • Anti-inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid. SORIANO-HERNANDEZ, ALEJANDRO D.; MADRIGAL-PÉREZ, DANIELA; GALVAN-SALAZAR, HECTOR R.; MARTINEZ-FIERRO, MARGARITA L.; VALDEZ-VELAZQUEZ, LAURA L.; ESPINOZA-GÓMEZ, FRANCISCO; VAZQUEZ-VUELVAS, OSCAR F.; OLMEDOBUEN-ROSTRO, BERTHA A.; GUZMAN-ESQUIVEL, JOSE; RODRIGUEZ-SANCHEZ, IRAM P.; LARA-ESQUEDA, AGUSTIN; MONTES-GALINDO, DANIEL A.; DELGADO-ENCISO, IVAN // Oncology Letters;Oct2015, Vol. 10 Issue 4, p2574 

    Uterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require...

  • SYNTHESIS OF 2, 4, 5- TRIPHENYL IMIDAZOLE DERIVATIVES AND BIOLOGICAL EVALUATION FOR THEIR ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITY. Burungale, Swati D.; Bhitre, M. J. // International Journal of Pharmaceutical Sciences & Research;Oct2013, Vol. 4 Issue 10, p4051 

    On the basis of various literature survey, imidazole derivatives show various activity such as antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic...

  • A BRIEF REVIEW ON RECENT SYNTHESIS OF 2-AZETIDINONE DERIVATIVES. Salunkhe, D. S.; Piste, P. B. // International Journal of Pharmaceutical Sciences & Research;Mar2014, Vol. 5 Issue 3, p666 

    The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic...

  • A REVIEW ON HEPATOPROTECTIVE ACTIVITY. Bhaargavi, Vuyyuri; Jyotsna, G. S. L.; Tripurana, Reshma // International Journal of Pharmaceutical Sciences & Research;Mar2014, Vol. 5 Issue 3, p690 

    Liver, the largest gland functioning as an organ of storage, manufacturing and biotransformation is a vulnerable target for injury. Chronic alcohol consumption, exposure to toxic chemicals and certain drugs like paracetamol, tetracycline, antitubercular drugs, chemotherapeutic agents, NSAIDS,...

  • Synthesis and Biological Activities of Some 1, 3, 4-Oxadiazole Based Schiff's Bases. Naik, Pravin P.; Somani, Rakesh R.; Waghulde, Sandeep O.; Pritam Juvatkar; Shirodkar, Prabhakar Y.; Kale, Mohan K. // International Journal of Pharmaceutical & Phytopharmacological R; 

    In the present study a series of 1, 3, 4-oxadiazole based Schiff's bases (4a-4i) were synthesized and characterized by IR and NMR spectroscopy. The synthesized compounds were evaluated for their preliminary in-vitro anti-cancer activities. Compound 4h showed better anticancer activity (GI 50...

  • Synthesis and biological evaluation of some new oxadiazole and pyrazole derivatives incorporating benzofuran moiety. Hanumanagoud H.; Basavaraja, K. M. // Der Pharma Chemica;2013, Vol. 5 Issue 4, p87 

    The reaction of 7-methoxy-benzofuran-2-carboxylic acid hydrazide (2) with acetic anhydride gave the acetyl derivative 3, which underwent cyclisation by treatment with POCl3 yielded 4, with ethylchloroformate in methanol yielded 5 and with ethylchloroformate in dry benzene followed by POCl3...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics