TITLE

Formulation and Evaluation of Matrix-based Sustained Release Tablets of Quetiapine fumarate and the Influence of Excipients on Drug Release

AUTHOR(S)
Gawali, Pranjali; Gupta, Anand; Kachare, Sayali; Kshirsagar, Sanjay
PUB. DATE
June 2012
SOURCE
Journal of Chemical & Pharmaceutical Research;2012, Vol. 4 Issue 6, p3073
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of the present study was to develop and characterize an oral sustain release drug delivery system for commonly prescribed antipsychotic Quetiapine fumarate. Hydrophilic matrix based tablets using different concentrations of different grades of hydroxypropyl methylcellulose (HPMC) viz. K100 LV and K4M CR was developed using wet granulation technique. The prepared tablets were of 50mg dose and were designed for oncedaily administration. The formulations prepared were evaluated for the release of Quetiapine fumarate over a period of 24 hrs. using USP type II dissolution test apparatus. The prepared tablets were evaluated for physical properties. The in- vitro drug release studies revealed that the tablets containing 15% of HPMC K4M CR of the total tablet weight showed satisfactory results and was able to control the release over 22 hrs. Further the influence of commonly used excipients viz. Lactose, MCC and Starch 1500 was studied on the selected formulation. The invitro release data of prepared formulations followed Korsmeyer- Peppas and Higuchi kinetics strongly. The selected formulation was compared with the marketed product for the drug release pattern and was matched using similarity factor (f2) above 50. In conclusion, the dissolution profiles and the mathematical model fittings indicate that release of Quetiapine fumarate can be effectively controlled by use of hydrophilic matrix systems.
ACCESSION #
87976840

 

Related Articles

  • FORMULATION AND IN-VITRO EVALUTION OF SUSTAINED RELEASE TABLET OF NIFIDIPINE USING HYDROPHILIC POLYMER. Donga, J. J.; Surani, V. S.; Chauhan, S. P.; Aundhia, C. J.; Seth, A. K. // Pharma Science Monitor;Oct2012, Vol. 3 Issue 4, p1745 

    Conventional drug delivery system for treating the angina and hypertension are not much effective as the drug do not reach the site of action in appropriate concentration. Thus an effective and safe therapy of this angina and hypertension disorder using specific drug delivery system is a...

  • FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE. Patel, Hardik; Patel, M. M. // International Journal of Pharmaceutical Sciences & Research;Jun2012, Vol. 3 Issue 6, p1761 

    Controlled porosity osmotic tablet of metoprolol succinate prepared and evaluated in this study. Metoprolol succinate is very high soluble drug, so complete drug release obtained very fast. It is difficult to formulate osmotic tablet of Metoprolol succinate which gives drug release up to 24 hr...

  • Formulation and evaluation of press coated tablets of salbutamol sulphate for time controlled release. Wasimul Hasan, M. D.; Someshwar, Komuravelly; Chaitanya, Patha; Mohd, Abdul Bari; Pratyusha, Ande; Maheshwara Rao, Vattikuti Uma // Asian Journal of Pharmaceutics (Medknow Publications & Media Pvt;Jul-Sep2014, Vol. 8 Issue 3, p161 

    The objective of the present study was to formulate and evaluate a press coated pulsatile drug delivery system of salbutamol sulphate in order to attain a time controlled release for treatment of nocturnal asthma. The core was prepared by direct compression, while press coating technique was...

  • A REVIEW ON SUSTAINED RELEASE DRUG DELIVERY SYSTEM. Bankar, A. U.; Bankar, V. H.; Gaikwad, P. D.; Pawar, S. P. // Pharma Science Monitor;Nov2012 Supply1, Vol. 3 Issue 4, p2049 

    Among all drug delivery systems, oral drug delivery is the most preferred route for administration for various drugs. Availability of wide variety of polymers and frequent dosing intervals helps the formulation scientist to develop sustained/controlled release products. Oral sustained release...

  • A review on application of multifunctional mesoporous nanoparticles in controlled release of drug delivery. Dave, Pragnesh N.; Chopda, Lakha V. // Materials Science Forum;2014, Vol. 781, p17 

    In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application in biotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural...

  • EMULGEL: AN EMERGENT TOOL IN TOPICAL DRUG DELIVERY. Hardenia, Anu; Jayronia, Sonali; Jain, Sanjay // International Journal of Pharmaceutical Sciences & Research;2014, Vol. 5 Issue 5, p1653 

    In comparison among the other groups of semisolid preparations, the use of gels has been emerged both in cosmetics and in pharmaceutical preparations because of its unique array of features. Despite of providing several benefits the category gel faces limitations in delivering hydrophobic drug...

  • Double-layer Tablets of Lornoxicam: Validation of Quantification Method, In vitro Dissolution and Kinetic Modelling. Gönüllü, Ümit; Gürpınar, Pınar; Üner, Melike // Tropical Journal of Pharmaceutical Research;Sep2015, Vol. 14 Issue 9, p1659 

    Purpose: To formulate double-layer tablets of lornoxicam (LRX) prepared by direct compression method and evaluate their physical and drug release characteristics. Methods: The outer layer of tablets, composed of microcrystalline cellulose (MCC), starch and lactose, incorporated tan initial or...

  • DESIGN AND DEVELOPMENT OF BIOADHESIVE GASTRO RETENTIVE ORAL TABLETS USING DIFFERENT POLYMERS. Harsulkar, Amol A.; Sreenivas, S. A. // Pharmacie Globale;Apr2013, Vol. 4 Issue 4, p1 

    Several approaches have been suggested to increase GI transit time, addressing the issue of localized drug delivery. The controlled gastric retention of solid dosage forms may be achieved by the mechanism of bioadhesion. Since the bioadhesive drug delivery system has ability to maintain a...

  • NOVEL PARADIGMS IN MUCOADHESIVE DRUG DELIVERY SYSTEM. Sharma, Deepak; Singh, Mankaran; Kumar, Dinesh; Singh, Gurmeet // International Journal of Pharmaceutical Sciences & Research;Aug2012, Vol. 3 Issue 8, p2455 

    Mucoadhesion is a field of current interest in the design of drug delivery systems. Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery system may be designed to enable prolonged residence time of the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics