TITLE

Estimation of zaleplon by a new RP-HPLC method

AUTHOR(S)
Tentu, Nageswara Rao; Reddy, E. G. Srineevasula; Patrudu, T. B.; Parvathamma, T.
PUB. DATE
June 2012
SOURCE
Journal of Chemical & Pharmaceutical Research;2012, Vol. 4 Issue 6, p3010
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A Simple, Sensitive and specific reverse phase high performance liquid chromatographic method has been developed for the determination of Zaleplon tablet Dosage Forms. Chromatographic separation was achieved on a Symmetry C8 (250 x 4.6 mm), 5.0 μm column with a 60:25:15mixture of 0.02M potassium dihydrogen phosphate w/v, acetonitrile v/v and methanol v/v as mobile phase, detection was at 240 nm. Response was a linear function of concentration in the range 2-0.01 μg/mL for Zaleplon. LOD and LOQ for Zaleplon were found 0.01 mg/L and 0.03 mg/L. Accuracy (recoveries 92-98%) and reproducibility were found to satisfactory.
ACCESSION #
87976830

 

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