Significant frequency of allelic imbalance in 3p region covering RARβ and MLH1 loci seems to be essential in molecular non-small cell lung cancer diagnosis

Antczak, Adam; Migdalska-Sęk, Monika; Pastuszak-Lewandoska, Dorota; Czarnecka, Karolina; Nawrot, Ewa; Domańska, Daria; Kordiak, Jacek; Górski, Paweł; Brzeziańska, Ewa
June 2013
Medical Oncology;Jun2013, Vol. 30 Issue 2, p1
Academic Journal
No abstract available.


Related Articles

  • Loss of heterozygosity is related to p53 mutations and smoking in lung cancer. Zienolddiny, S; Ryberg, D; Arab, M O; Skaug, V; Haugen, A // British Journal of Cancer;1/15/2001, Vol. 84 Issue 2, p226 

    Carcinogenesis results from an accumulation of several genetic alterations. Mutations in the p53 gene are frequent and occur at an early stage of lung carcinogenesis. Loss of multiple chromosomal regions is another genetic alteration frequently found in lung tumours. We have examined the...

  • Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study. Czarnecka, Karolina H.; Migdalska-Sęk, Monika; Antczak, Adam; Pastuszak-Lewandoska, Dorota; Kordiak, Jacek; Nawrot, Ewa; Domańska, Daria; Kaleta, Dorota; Górski, Paweł; Brzeziańska, Ewa Barbara // Molecular Biology Reports;Dec2013, Vol. 40 Issue 12, p6671 

    In lung cancer pathogenesis, genetic instability, i.e., loss of heterozygosity (LOH) and microsatellite instability (MSI) is a frequent molecular event, occurring at an early stage of cancerogenesis. The presence of LOH/MSI in non-small cell lung carcinoma (NSCLC) was found in many chromosomal...

  • Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome. Morak, Monika; Koehler, Udo; Schackert, Hans Konrad; Steinke, Verena; Royer-Pokora, Brigitte; Schulmann, Karsten; Kloor, Matthias; H+ACYAIw-x00F6+ADs-chter, Wilhelm; Weingart, Josef; Keiling, Cortina; Massdorf, Trisari; Holinski-Feder, Elke // Journal of Medical Genetics;Aug2011, Vol. 48 Issue 8, p513 

    Background A positive family history, germline mutations in DNA mismatch repair genes, tumours with high microsatellite instability, and loss of mismatch repair protein expression are the hallmarks of hereditary non-polyposis colorectal cancer (Lynch syndrome). However, in w10e15% of cases of...

  • Genetic and Epigenetic Tumor Suppressor Gene Silencing Are Distinct Molecular Phenotypes Driven by Growth Promoting Mutations in Nonsmall Cell Lung Cancer. Marsit, Carmen J.; Houseman, E. Andres; Nelson, Heather H.; Kelsey, Karl T. // Journal of Cancer Epidemiology;2008, p1 

    Both genetic and epigenetic alterations characterize human nonsmall cell lung cancer (NSCLC), but the biological processes that create or select these alterations remain incompletely investigated. Our hypothesis posits that a roughly reciprocal relationship between the propensity for promoter...

  • Diagnostic value of DNA alteration: loss of heterozygosity or allelic imbalance-promising for molecular staging of prostate cancers. Bryś, Magdalena; Migdalska-Sęk, Monika; Pastuszak-Lewandoska, Dorota; Forma, Ewa; Czarnecka, Karolina; Domańska, Daria; Nawrot, Ewa; Wilkosz, Jacek; Różański, Waldemar; Brzeziańska, Ewa // Medical Oncology;Mar2013, Vol. 30 Issue 1, p1 

    The biological behavior of prostate cancer is uncertain, and therefore, search for molecular prognostic markers associated with disease progression seems to be essential. We performed microsatellite allelotyping of DNA isolated from primary prostate tumors biopsies (prostate adenocarcinoma,...

  • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Seng, T J; Currey, N; Cooper, W A; Lee, C-S; Chan, C; Horvath, L; Sutherland, R L; Kennedy, C; McCaughan, B; Kohonen-Corish, M R J // British Journal of Cancer;7/22/2008, Vol. 99 Issue 2, p375 

    The significance of chromosome 3p gene alterations in lung cancer is poorly understood. This study set out to investigate promoter methylation in the deleted in lung and oesophageal cancer 1 (DLEC1), MLH1 and other 3p genes in 239 non-small cell lung carcinomas (NSCLC). DLEC1 was methylated in...

  • Expression of the Mismatch Repair Gene hMLH1 Is Enhanced in Non-Small Cell Lung Cancer with EGFR Mutations. Li, Mei; Zhang, Qiuping; Liu, Lina; Lu, Weipeng; Wei, Hong; Li, Rachel W.; Lu, Shen // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Mismatch repair (MMR) plays a pivotal role in keeping the genome stable. MMR dysfunction can lead to carcinogenesis by gene mutation accumulation. HMSH2 and hMLH1 are two key components of MMR. High or low expression of them often mark the status of MMR function. Mutations (EGFR, KRAS, etc) are...

  • Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers. Yasuyuki Miyakura; Makiko Tahara; Lefor, Alan T.; Yoshikazu Yasuda; Kokichi Sugano // BMC Research Notes;2014, Vol. 7 Issue 1, p1 

    Background Methylation of the MLH1 promoter region has been suggested to be a major mechanism of gene inactivation in sporadic microsatellite instability-positive (MSI-H) colorectal cancers (CRCs). Recently, single-nucleotide polymorphism (SNP) in the MLH1 promoter region (MLH1-93G/A; rs1800734)...

  • Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. Yi-Ching Wang; Yung-Pin Lu; Ruo-Chia Tseng; Ruo-Kai Lin; Jer-Wei Chang; Jung-Ta Chen; Chuen-Ming Shih; Chich-Yi Chen // Journal of Clinical Investigation;3/15/2003, Vol. 111 Issue 6, p887 

    Presents a study which identified the molecular basis for loss of hMLH1 protein expression. Possible involvement of another mismatch repair protein, hMSH2, in non-small cell lung cancer tumorigenesis; Methodologies of the study; Results of the study.

  • MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells. Zhong, Zhiwei; Dong, Zhuo; Yang, Lihua; Chen, Xiaoqiang; Gong, Zhaohui // Tumor Biology;Jun2013, Vol. 34 Issue 3, p1959 

    MicroRNAs (miRNAs) and DNA mismatch repair (MMR) have been linked to human cancer progression. Human mutL homolog 1 (hMLH1), one of the core MMR genes, defects in lung cancer development. However, the interaction between miRNAs and MMR genes and their regulatory effect on cell cycle remain...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics