High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients

Butrym, Aleksandra; Majewski, Miroslaw; Dzietczenia, Justyna; Kuliczkowski, Kazimierz; Mazur, Grzegorz
June 2013
Medical Oncology;Jun2013, Vol. 30 Issue 2, p1
Academic Journal
No abstract available.


Related Articles

  • Chronic Lymphocytic Leukemia: Biology ZAP.  // Hematology Journal;2004 Supplement 2, Vol. 5, pS219 

    Presents abstracts of studies on chronic lymphocytic leukemia and ZAP-70 protein tyrosine kinase. ZAP-70 protein tyrosine kinase is an independent marker of disease progression in B-cell chronic lymphocytic leukemia; ZAP-70 protein expression is negative and the promoter region is methylated, in...

  • ZAP70: a master regulator of adaptive immunity. Fischer, Alain; Picard, Capucine; Chemin, Karine; D6ogniaux, Stéphanie; le Deist, Françoise; Hivroz, Claire // Seminars in Immunopathology;Jun2010, Vol. 32 Issue 2, p107 

    The protein tyrosine kinase ZAP70 became the subject of intense scrutiny in the early nineties, when ZAP70 mutations were characterized in several young patients presenting with severe T cell immunodeficiencies. The association of a lack of expression of ZAP70 with an immunodeficiency consisting...

  • Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia. Schroers, R.; Griesinger, F.; Trümper, L.; Haase, D.; Kulle, B.; Klein-Hitpass, L.; Sellmann, L.; Dührsen, U.; Dürig, J. // Leukemia (08876924);May2005, Vol. 19 Issue 5, p750 

    Prognostic predictions in B-cell chronic lymphocytic leukemia (B-CLL) at early clinical stage are based on biological disease parameters, such as ZAP-70 and CD38 protein levels, genomic aberrations as well as immunoglobulin variable heavy chain gene (IgVH) mutation status. In the current study,...

  • ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Scielzo, C.; Camporeale, A.; Geuna, M.; Alessio, M.; Poggi, A.; Zocchi, M. R.; Chilosi, M.; Caligaris-Cappio, F.; Ghia, P. // Leukemia (08876924);Apr2006, Vol. 20 Issue 4, p689 

    ZAP-70 tyrosine kinase is involved in signalling pathways following T-cell receptor stimulation and was originally described only in T cells and natural killer cells. ZAP-70 expression has been reported in normal mouse B lineage cells and in human malignant B lymphocytes, mainly in chronic...

  • Expression of multidrug resistance-associated ABC transporters in B-CLL is independent of ZAP70 status. Hoellein, Alexander; Decker, Thomas; Bogner, Christian; Oelsner, Madlen; Hauswald, Stefanie; Peschel, Christian; Keller, Ulrich; Licht, Thomas // Journal of Cancer Research & Clinical Oncology;Mar2010, Vol. 136 Issue 3, p403 

    To assess whether the poor prognosis of ZAP70-positive B-cell chronic lymphocytic leukemia (CLL) is associated with the overexpression of ABC transporter genes that are responsible for pleiotropic drug resistance. The transcript level of ten drug transporters was analyzed using semiquantitative...

  • ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value. Hus, Iwona; Bojarska-Junak, Agnieszka; Dmoszyńska, Anna; Wąsik-Szczepanek, Ewa; Sieklucka, Malgorzata; Trześniewska, Wioletta; Glazer, Magdalena; Roliński, Jacek // Folia Histochemica et Cytobiologica;2008, Vol. 46 Issue 2, p147 

    Recently identified biological risk factors in B-cell chronic lymphocytic leukemia (B-CLL) include ZAP-70 and CD38 expression. The present study was conducted to clarify whether a combined analysis could improve predictive impact of these two parameters. We examined the expression of ZAP-70 and...

  • Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. Hüttmann, A.; Klein-Hitpass, L.; Thomale, J.; Deenen, R.; Carpinteiro, A.; Nückel, H.; Ebeling, P.; Führer, A.; Edelmann, J.; Sellmann, L.; Dührsen, U.; Dürig, J. // Leukemia (08876924);Oct2006, Vol. 20 Issue 10, p1774 

    B-cell chronic lymphocytic leukaemia (B-CLL) is a heterogenous disease with a highly variable clinical course and analysis of zeta-associated protein 70 (ZAP-70) and CD38 expression on B-CLL cells allowed for identification of patients with good (ZAP-70−CD38−) and poor (ZAP-70+CD38+)...

  • Immunoglobulin VH Genes and CD38 Expression Analysis in B-Cell Chronic Lymphocytic Leukemia. Bagli, Laura; Zucchini, Alessandra; Innoceta, Anna Maria; Zaccaria, Alfonso; Cipriani, Raffaella; Fattori, Pier Paolo; Ravaioli, Alberto // Acta Haematologica;2006, Vol. 116 Issue 1, p72 

    Examines the correlation of immunoglobulin heavy chain gene mutation analysis and CD38 expression on B cells in line with the clinical diagnosis of B-cell chronic lymphocytic leukemia (B-CLL). Disadvantages of immunoglobulin heavy chain gene mutation analysis as a diagnostic tool for B-CLL;...

  • Utility of Quantitative Flow Cytometry Immunophenotypic Analysis of CD5 Expression in Small B-Cell Neoplasms. Challagundla, Pramoda; Jorgensen, Jeffrey L.; Kanagal-Shamanna, Rashmi; Gurevich, Inga; Pierson, Diane M.; Ferrajoli, Alessandra; Reyes, Steven R.; Medeiros, L. Jeffrey; Miranda, Roberto N. // Archives of Pathology & Laboratory Medicine;Jul2014, Vol. 138 Issue 7, p903 

    Context.—The value of assessing CD5 expression in the differential diagnosis of small B-cell neoplasms is well established. Assessment is usually done qualitatively. Objectives.—To assess CD5 expression levels by quantitative flow cytometry immunophenotyping and to determine...

  • Clinical Prognostic Biomarkers in Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma. Chastain, Elizabeth C.; Duncavage, Eric J. // Archives of Pathology & Laboratory Medicine;May2015, Vol. 139 Issue 5, p602 

    Context.—Diffuse large B-cell lymphoma and chronic lymphocytic leukemia are 2 of the most common B-cell lymphomas in adults. Both diffuse large B-cell lymphoma and chronic lymphocytic leukemia share heterogeneous outcomes, and the use of prognostic biomarkers to better stratify risk in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics