An ODE Model of Dopamine Receptor Availability and Trafficking

Villar, John Justine S.; Arceo, Carlene Perpetua P.; Mendoza, Eduardo R.
October 2012
International Proceedings of Chemical, Biological & Environmenta;2012, Vol. 45, p54
Academic Journal
The dopaminergic system has been extensively studied for 40 years as it affects vital neurological, gastrointestinal, cardiovascular and renal processes, among others. It has been observed that disorders in the dopamine receptor system can be associated to the failure of dopamine to inhibit various processes that leads to serious pathological conditions such as Parkinson's disease, schizophrenia and hypertension, among others. This paper presents an ordinary differential equation (ODE) model of dopamine receptor availability and intracellular trafficking derived from Zeng et al (2004) including receptor activation, desensitization, internalization, degradation and recycling. The proposed model will illustrate the dynamics of receptor trafficking and the effects of various mechanisms that affect cell surface receptor availability.


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