TITLE

Epidemiology and prognosis of brain metastases

AUTHOR(S)
Stelzer, Keith J.
PUB. DATE
July 2013
SOURCE
Surgical Neurology International;2013, Vol. 4 Issue 5, pS192
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A substantial, but uncertain, number of patients with cancer develop brain metastases. Risk of brain metastasis is recognized to vary with type of primary cancer. Within specific types of primary cancer, prognostic factors for development of brain metastases are being recognized. Recent data suggest that molecular biomarkers that relate to cellular function can predict risk of developing brain metastases. Such information could optimize surveillance standards and/or be used to select patients for preventive interventions. Though average survival for patients with brain metastases is typically less than 6 months, it is well-recognized that subgroups of patients have significant probability of longer survival. Multiple prognostic models have been proposed, validated, and compared without clearly demonstrating superiority of one model over another. However, some factors show consistency as predictive variables across models, and performance status is almost universally significant. Application of predictive models to specific treatments has been difficult. Tumor-specific prognostic models are evolving, and combinations of biological and clinical factors may be used to optimize models for particular primary tumor types.
ACCESSION #
87627025

 

Related Articles

  • The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer. Sperduto, Paul; Kased, Norbert; Roberge, David; Chao, Samuel; Shanley, Ryan; Luo, Xianghua; Sneed, Penny; Suh, John; Weil, Robert; Jensen, Ashley; Brown, Paul; Shih, Helen; Kirkpatrick, John; Gaspar, Laurie; Fiveash, John; Chiang, Veronica; Knisely, Jonathan; Sperduto, Christina; Lin, Nancy; Mehta, Minesh // Journal of Neuro-Oncology;May2013, Vol. 112 Issue 3, p467 

    Our group has previously published the Diagnosis-Specific Graded Prognostic Assessment (GPA) showing the prognostic factors associated with survival in patients with brain metastases (BM). The purpose of this study is to investigate the relationship of breast cancer subtype to the time interval...

  • S100B protein as a possible participant in the brain metastasis of NSCLC. Pang, Xiaowen; Min, Jie; Liu, Lili; Liu, Yi; Ma, Ningqiang; Zhang, Helong // Medical Oncology;Dec2012, Vol. 29 Issue 4, p2626 

    Brain metastasis is a frequent occurrence in lung cancer, especially non-small cell lung cancer (NSCLC), the prognosis for NSCLC with brain metastasis is very poor. Our previous study found high S100B expression in the brain-specific metastatic NSCLC line PC14/B, suggested S100B is closely...

  • A new grading system focusing on functional preservation for brain metastasis patients treated with gamma knife surgery. T. Serizawa; Y. Higuchi; O. Agano; S. Matsuda; J. Ono; N. Saeki; T. Hirai; A. Miyakawa; Y. Shibamoto // Journal of Radiosurgery & SBRT;2013 Supplement 2.1, Vol. 2, p5 

    Purpose: Functional preservation (qualitative survival, QS) has been regarded as one of the ideal endpoints for evaluating treatment results for patients with brain metastases. However, previous reports on grading systems for brain metastasis patients, i.e. RPA, SIR, BSBM and GPA, are based on...

  • Predictive factors for the development of brain metastases in patients with malignant melanoma: a study by the Anatolian society of medical oncology. Gumusay, Ozge; Coskun, Ugur; Akman, Tülay; Ekinci, Ahmet; Kocar, Muharrem; Erceleb, Özlem; Yazıcı, Ozan; Kaplan, Mehmet; Berk, Veli; Cetin, Bulent; Taskoylu, Burcu; Yildiz, Ayhan; Goksel, Gamze; Alacacioglu, Ahmet; Demirci, Umut; Algin, Efnan; Uysal, Mukremin; Oztop, Ilhan; Oksuzoglu, Berna; Dane, Faysal // Journal of Cancer Research & Clinical Oncology;Jan2014, Vol. 140 Issue 1, p151 

    Background: The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify...

  • Clinical interrogation and application of super-selective intracranial artery infusion chemotherapy for lung cancer patients with brain metastases. Rong J.; Chunhua M.; Yuan L.; Ning M.; Jinduo L.; Bin W.; Liwei S.; Rong, J; Chunhua, M; Yuan, L; Ning, M; Jinduo, L; Bin, W; Liwei, S // Indian Journal of Cancer;2015 Special issue 1, Vol. 52, pe22 

    Objective: The purpose of this study was to evaluate the clinical efficacy of super-selective intracranial artery infusion chemotherapy and to determine correlated prognostic parameters for advanced lung cancer patients with brain metastases.Patients and Methods:...

  • Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival. Jae-Young Park; Kyung-Sub Moon; Kyung-Hwa Lee; Sa-Hoe Lim; Woo-Youl Jang; Hyeseon Lee; Tae-Young Jung; In-Young Kim; Shin Jung // BMC Cancer;2015, Vol. 15 Issue 1, p1 

    Background: Gamma knife radiosurgery (GKRS) has been increasingly employed for the treatment of elderly patients with brain metastases, mainly due to its demonstrated effectiveness and low complication rate. However, only a few studies have investigated the prognostic factors that influence the...

  • Gliadel for brain metastasis. Abel, Taylor J.; Ryken, Timothy; Lesniak, Maciej S.; Gabikian, Patrik // Surgical Neurology International;2013, Vol. 4 Issue 5, pS289 

    With therapies for systemic malignancy improving, life expectancy for cancer patients is becoming increasingly dependent on control of brain metastatic disease. Despite improvements in surgical and radiotherapy modalities for control of brain metastasis, the prognosis for patients with brain...

  • Whole brain helical Tomotherapy with integrated boost for brain metastases in patients with malignant melanoma--a randomized trial. Hauswald, Henrik; Habl, Gregor; Krug, David; Kehle, Denise; Combs, Stephanie E.; Bermejo, Justo Lorenzo; Debus, Jürgen; Sterzing, Florian // Radiation Oncology;2013, Vol. 8 Issue 1, p1 

    Background Patients with malignant melanoma may develop brain metastases during the course of the disease, requiring radiotherapeutic treatment. In patients with 1-3 brain metastases, radiosurgery has been established as a treatment option besides surgery. For patients with 4 or more brain...

  • Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases.  // Breast Cancer Research;2011, Vol. 13 Issue 4, p3071 

    The article focuses on a study that examined the activation status of the phosphatidylinositol 3-kinase (PI3K) pathway in breast cancer brain metastases (BCBMs). The PI3K pathway was found to be active in most BCBMs. BCBMs from 52 patients treated at the University of North Carolina at Chapel...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics