TITLE

Anti-TNF Therapy Reduces Serum Levels of Chemerin in Rheumatoid Arthritis: A New Mechanism by Which Anti-TNF Might Reduce Inflammation

AUTHOR(S)
Herenius, Marieke M. J.; Oliveira, Ana S. F.; Wijbrandts, Carla A.; Gerlag, Daniëlle M.; Tak, Paul P.; Lebre, Maria C.
PUB. DATE
February 2013
SOURCE
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC). In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins and adhesion molecules and is able to activate fibroblast-like synoviocytes (FLS), suggesting a role in the pathogenesis of rheumatoid arthritis (RA). Chemerin is also an adipocytokine that has been related to the inflammatory state of endothelial cells and as such could be involved in the changes in endothelial cells in RA and perhaps increased cardiovascular morbidity. We investigated whether anti-Tumor Necrosis Factor (TNF) treatment affects chemerin levels. Materials and Methods: 49 patients with active RA (disease activity score evaluated in 28 joints (DAS28) ≥3.2) were started on adalimumab therapy. Blood was drawn from patients while fasting at baseline and 16 weeks after initiation of treatment. Chemerin serum levels were measured by ELISA and related to disease activity, mediators of inflammation and known risk factors for cardiovascular disease. Results: Adalimumab therapy reduced chemerin serum levels, which was correlated with the reduction in DAS28 (r = 0.37, p = 0.009). In addition, the decrease in chemerin serum levels after anti-TNF treatment was associated with the decrease in serum levels of IL-6 (r = 0.39, p = 0.033) and macrophage migration inhibitory factor (MIF) (r = 0.31, p = 0.049). Baseline chemerin serum levels were not related to traditional risk factors for atherosclerosis, except perhaps for smoking (p = 0.07). Conclusions: This exploratory study shows that adalimumab therapy lowers chemerin levels, which is associated with the reduction in disease activity parameters, and inflammatory mediators IL-6 and MIF. This suggests a possible involvement of chemerin in the migration/retention of macrophages in the synovium. Trial Registration Nederlands Trial Register: NTR 857
ACCESSION #
87625652

 

Related Articles

  • Tumor Necrosis Factor-∝ Induces Interleukin-1∝ and Interleukin-1 Receptor Antagonist Production by Cultured Human Keratinocytes. Kutsch, Charlotte L.; Norris, David A.; Arend, William P. // Journal of Investigative Dermatology;Jul93, Vol. 101 Issue 1, p79 

    Interleukin-1 (IL-1) may have a significant pro-inflammatory effect in the skin; an imbalance in its production has been linked to cutaneous disease processes. IL-i receptor antagonist (IL-1ra) is a recently described competitive inhibitor of IL-1α and IL-1β that binds to human types I and...

  • Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats. Pragasam, Samuel; Venkatesan, Vijayalakshmi; Rasool, MahaboobKhan // Inflammation;Feb2013, Vol. 36 Issue 1, p169 

    In this study, p-coumaric acid was evaluated for its immunomodulatory and anti-inflammatory properties in vivo. The immunomodulatory effect of p-coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity reaction),...

  • Targeting the Coagulation Factor Fibrinogen for Arthritis Therapy. Raghu, Harini; Flick, Matthew J. // Current Pharmaceutical Biotechnology;Sep2011, Vol. 12 Issue 9, p1497 

    Fibrinogen is a provisional matrix protein of the coagulation system that following proteolytic cleavage by the protease thrombin polymerizes to form fibrin, the structural basis of the blood clot. Fibrin polymer formation at sites of vessel injury is critical to normal hemostasis. However,...

  • Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus. Milićević, Novica; Miljković, Miloš; Milićević, Živana; Labudović-Borović, Milica; Wang, Xiaoping; Laan, Martti; Peterson, Pärt; Randall, Troy; Westermann, Jürgen // Histochemistry & Cell Biology;Jun2011, Vol. 135 Issue 6, p593 

    We have already shown that metallophilic macrophages, which represent an important component in the thymus physiology, are lacking in lymphotoxin-β receptor-deficient mice. However, further molecular requirements for the development and correct tissue positioning of these cells are unknown....

  • P735 Regulation of macrophage polarization by extracellular RNA: The role of sialoadhesin-1. Cabrera-Fuentes, H A; Galuska, S; Meiler, S; Baumer, Y; Mccurdy, S; Fischer, S; Preissner, KT; Boisvert, W // Cardiovascular Research;Jul2014, Vol. 103 Issue suppl_1, pS135 

    Macrophages respond to external stimuli with rapid changes in their expression of many inflammation-related genes to undergo polarization towards the M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotype. This unique property of macrophages allows these cells to modulate chronic inflammatory...

  • Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis. Shimizu, Tadamichi; Niizeki, Hironori; Takeuchi, Osamu; Yamasaki, Yuichiro; Inamoto, Nobuko; Kusunok, Yukihiro; Kobayashi, Kunihiko; Abe, Riichiro; Shimizu, Hiroshi; Nishikawa, Takeji; Hashiguchi, Kazuhiro; Nishihira, Jun // Mediators of Inflammation;Aug2004, Vol. 13 Issue 4, p293 

    We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test ( n =29). To confirm...

  • TNF-a increases human melanoma cell invasion and migration in vitro: the role of proteolytic enzymes. Katerinaki, E.; Evans, G.S.; Lorigan, P.C.; MacNeil, S. // British Journal of Cancer;9/15/2003, Vol. 89 Issue 6, p1123 

    Inflammatory mediators have been reported to promote malignant cell growth, invasion and metastatic potential. More specifically, we have recently reported that tumour necrosis factor alpha (TNF-a) increases melanoma cell attachment to extracellular matrix (ECM) substrates and invasion through...

  • The tale of TL1A in inflammation. Hsu, H.; Viney, J. L. // Mucosal Immunology (1933-0219);Jul2011, Vol. 4 Issue 4, p368 

    TL1A (also known as TNFSF15) is a tumor necrosis factor (TNF) family member expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells in response to stimulation by cytokines, immune complexes, and microorganisms.1, 2, 3, 4, 5 Its cell surface...

  • Interleukin-7 in rheumatoid arthritis. S. M. Churchman; F. Ponchel // Rheumatology;Jun2008, Vol. 47 Issue 6, p753 

    Recent data from several groups demonstrate high levels of IL-7 in the joints of RA patients, but much lower levels in OA. In contrast, circulating levels of IL-7 in RA remain a point of debate. IL-7 has many roles in T cell, dendritic cell and bone biology in humans. Reduced levels of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics