Developmental Fluoxetine Exposure Normalizes the Long-Term Effects of Maternal Stress on Post-Operative Pain in Sprague-Dawley Rat Offspring

Knaepen, Liesbeth; Rayen, Ine; Charlier, Thierry D.; Fillet, Marianne; Houbart, Virginie; van Kleef, Maarten; Steinbusch, Harry W.; Patijn, Jacob; Tibboel, Dick; Joosten, Elbert A.; Pawluski, Jodi L.
February 2013
PLoS ONE;Feb2013, Vol. 8 Issue 2, p1
Academic Journal
Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the developing hypothalamic-pituitary-adrenal (HPA) system. Therefore, the present study investigated long-term effects of maternal adversity and/or SSRI medication use on nociception of adult Sprague-Dawley rat offspring, taking into account involvement of the HPA system. Dams were subject to stress during gestation and were treated with fluoxetine (2×/5 mg/kg/day) prior to parturition and throughout lactation. Four groups of adult male offspring were used: 1. Control+Vehicle, 2. Control+Fluoxetine, 3. Prenatal Stress+Vehicle, 4. Prenatal Stress+Fluoxetine. Results show that post-operative pain, measured as hypersensitivity to mechanical stimuli after hind paw incision, was decreased in adult offspring subject to prenatal stress alone and increased in offspring developmentally exposed to fluoxetine alone. Moreover, post-operative pain was normalized in prenatally stressed offspring exposed to fluoxetine. This was paralleled by a decrease in corticosteroid binding globulin (CBG) levels in prenatally stressed offspring and a normalization of serum CBG levels in prenatally stressed offspring developmentally exposed to fluoxetine. Thus, developmental fluoxetine exposure normalizes the long-term effects of maternal adversity on post-operative pain in offspring and these effects may be due, in part, to the involvement of the HPA system.


Related Articles

  • The hypothalamic-pituitary-adrenal axis and genetic variants affecting its reactivity. Chistyakova, N.; Savost'yanov, K. // Russian Journal of Genetics;Aug2011, Vol. 47 Issue 8, p895 

    The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in the body response to stresses. Activation of the HPA axis results in the production of corticosteroid hormones that influence a wide variety of body functions, including immunity, metabolism, ion exchange, and behavior. A...

  • Endocrinology of Stress. Romero, L. Michael; Butler, Luke K. // International Journal of Comparative Psychology;2007, Vol. 20 Issue 2/3, p89 

    When an animal detects a stressor, it initiates a stress response. The physiological aspects of this stress response are mediated through two endocrine systems. The catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla very rapidly and have numerous effects...

  • The 'koala stress syndrome' and adrenal responsiveness in the critically ill. Marik, Paul E.; Levitov, Alexander // Intensive Care Medicine;Nov2010, Vol. 36 Issue 11, p1805 

    The authors reflect on the koala stress syndrome in patients with critical illness-related corticosteroid insufficiency (CIRCI). It says that the release of cortisol results from the activation of the hypothalamic-pituitary-adrenal (HPA) axis due to various stressors including infections, trauma...

  • Investigation of Genetic Variants, Birthweight and Hypothalamic-Pituitary-Adrenal Axis Function Suggests a Genetic Variant in the SERPINA6 Gene Is Associated with Corticosteroid Binding Globulin in the Western Australia Pregnancy Cohort (Raine) Study. Anderson, Laura N.; Briollais, Laurent; Atkinson, Helen C.; Marsh, Julie A.; Xu, Jingxiong; Connor, Kristin L.; Matthews, Stephen G.; Pennell, Craig E.; Lye, Stephen J. // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Background: The hypothalamic-pituitary-adrenal (HPA) axis regulates stress responses and HPA dysfunction has been associated with several chronic diseases. Low birthweight may be associated with HPA dysfunction in later life, yet human studies are inconclusive. The primary study aim was to...

  • Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats. Jia Luo; Tao Wang; Shan Liang; Xu Hu; Wei Li; Feng Jin // Behavioral & Brain Functions;2013, Vol. 9 Issue 1, p1 

    Human and animals studies support the idea that there is a gender-related co-morbidity of pain-related and inflammatory gastrointestinal (GI) diseases with psychological disorders. This co-morbidity is the evidence for the existence of GI-brain axis which consists of immune (cytokines), neural...

  • Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease. Desramé, J.; Sabaté, J.M.; Agher, R.; Bremont, C.; Gaudric, M.; Couturier, D.; Chaussade, S. // American Journal of Gastroenterology;Jul2002, Vol. 97 Issue 7, p1785 

    OBJECTIVES:In patients with inflammatory bowel disease (IBD), little is known about the effect of long term corticosteroid therapy (CT) on the hypothalamic-pituitary-adrenal (HPA) axis function. Our aim was to assess HPA axis function in IBD, before the end of CT, during the tapering...

  • Role of biochemical assessment in management of corticosteroid withdrawal. Walsh, John P.; Dayan, Colin M. // Annals of Clinical Biochemistry;May2000, Vol. 37 Issue 3, p279 

    The article examines the role of biochemical tests of adrenal function in the management and monitoring of glucocorticoid withdrawal. The physiology of the hypothalamo-pituitary-adrenal (HPA) axis and the known effects of glucocorticoid treatment on the axis is reviewed. Dynamic tests of HPA...

  • Obesity Is More Than Just Overeating.  // Health & Stress;2002, Issue 5, p7 

    Explores the consequences of the increased hypothalamic-pituitary-adrenal (HPA) activity during chronic stress. Role of HPA axis in cortisol secretion; Influence of visceral obesity from chronic stress on the occurrence of insulin resistance; Factors significant for preventing obesity.

  • Functional role of local GABAergic influences on the HPA axis. Cullinan, William E.; Ziegler, Dana R.; Herman, James P. // Brain Structure & Function;Sep2008, Vol. 213 Issue 1/2, p63 

    Neuronatomical and pharmacological studies have established GABA-mediated inhibition of the HPA axis at the level of the PVN. The origin of this innervation is a series of local hypothalamic and adjacent forebrain regions that project to stress-integrative hypophysiotropic CRH neurons. While a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics